GB1456618A - Process for the production of solid preparations of sparingly soluble medicinally active compounds in a very finely divided form - Google Patents
Process for the production of solid preparations of sparingly soluble medicinally active compounds in a very finely divided formInfo
- Publication number
- GB1456618A GB1456618A GB77475A GB77475A GB1456618A GB 1456618 A GB1456618 A GB 1456618A GB 77475 A GB77475 A GB 77475A GB 77475 A GB77475 A GB 77475A GB 1456618 A GB1456618 A GB 1456618A
- Authority
- GB
- United Kingdom
- Prior art keywords
- finely divided
- sparingly soluble
- medicinally active
- production
- active compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- -1 Phenyltoin Chemical compound 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- ALARQZQTBTVLJV-CYBMUJFWSA-N (5r)-5-ethyl-1-methyl-5-phenyl-1,3-diazinane-2,4,6-trione Chemical compound C=1C=CC=CC=1[C@]1(CC)C(=O)NC(=O)N(C)C1=O ALARQZQTBTVLJV-CYBMUJFWSA-N 0.000 abstract 1
- SMNOERSLNYGGOU-UHFFFAOYSA-N Mefruside Chemical compound C=1C=C(Cl)C(S(N)(=O)=O)=CC=1S(=O)(=O)N(C)CC1(C)CCCO1 SMNOERSLNYGGOU-UHFFFAOYSA-N 0.000 abstract 1
- ARFHIAQFJWUCFH-IZZDOVSWSA-N Nifurtimox Chemical compound CC1CS(=O)(=O)CCN1\N=C\C1=CC=C([N+]([O-])=O)O1 ARFHIAQFJWUCFH-IZZDOVSWSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- VRDIULHPQTYCLN-UHFFFAOYSA-N Prothionamide Chemical compound CCCC1=CC(C(N)=S)=CC=N1 VRDIULHPQTYCLN-UHFFFAOYSA-N 0.000 abstract 1
- HMHVCUVYZFYAJI-UHFFFAOYSA-N Sultiame Chemical compound C1=CC(S(=O)(=O)N)=CC=C1N1S(=O)(=O)CCCC1 HMHVCUVYZFYAJI-UHFFFAOYSA-N 0.000 abstract 1
- SAZUGELZHZOXHB-UHFFFAOYSA-N acecarbromal Chemical compound CCC(Br)(CC)C(=O)NC(=O)NC(C)=O SAZUGELZHZOXHB-UHFFFAOYSA-N 0.000 abstract 1
- 229960001409 acecarbromal Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 229960004678 mefruside Drugs 0.000 abstract 1
- 229960001703 methylphenobarbital Drugs 0.000 abstract 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 abstract 1
- 229960000282 metronidazole Drugs 0.000 abstract 1
- XULACPAEUUWKFX-UHFFFAOYSA-N niclofolan Chemical compound C1=C(Cl)C=C([N+]([O-])=O)C(O)=C1C1=CC(Cl)=CC([N+]([O-])=O)=C1O XULACPAEUUWKFX-UHFFFAOYSA-N 0.000 abstract 1
- 229950006977 niclofolan Drugs 0.000 abstract 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 abstract 1
- 229960001597 nifedipine Drugs 0.000 abstract 1
- 229960002644 nifurtimox Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229960000918 protionamide Drugs 0.000 abstract 1
- 239000012439 solid excipient Substances 0.000 abstract 1
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 abstract 1
- 229960004306 sulfadiazine Drugs 0.000 abstract 1
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 abstract 1
- GPTONYMQFTZPKC-UHFFFAOYSA-N sulfamethoxydiazine Chemical compound N1=CC(OC)=CN=C1NS(=O)(=O)C1=CC=C(N)C=C1 GPTONYMQFTZPKC-UHFFFAOYSA-N 0.000 abstract 1
- 229960002229 sulfametoxydiazine Drugs 0.000 abstract 1
- JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 abstract 1
- 229960001544 sulfathiazole Drugs 0.000 abstract 1
- UEMLYRZWLVXWRU-UHFFFAOYSA-N sulfathiourea Chemical compound NC(=S)NS(=O)(=O)C1=CC=C(N)C=C1 UEMLYRZWLVXWRU-UHFFFAOYSA-N 0.000 abstract 1
- 229960002573 sultiame Drugs 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742400819 DE2400819C2 (de) | 1974-01-09 | 1974-01-09 | Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1456618A true GB1456618A (en) | 1976-11-24 |
Family
ID=5904386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB77475A Expired GB1456618A (en) | 1974-01-09 | 1975-01-08 | Process for the production of solid preparations of sparingly soluble medicinally active compounds in a very finely divided form |
Country Status (6)
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0047899A1 (de) * | 1980-09-09 | 1982-03-24 | Bayer Ag | Feste Arzneizubereitungen enthaltend Nifedipin und Verfahren zu ihrer Herstellung |
| US4344934A (en) * | 1978-11-20 | 1982-08-17 | American Home Products Corporation | Therapeutic compositions with enhanced bioavailability |
| US4411882A (en) | 1978-12-21 | 1983-10-25 | Sandoz Ltd. | Galenical compositions |
| US4412986A (en) | 1977-06-07 | 1983-11-01 | Yamanouchi Pharmaceutical Co. Ltd. | Nifedipine-containing solid preparation composition |
| US4537898A (en) * | 1983-03-03 | 1985-08-27 | Bayer Aktiengesellschaft | Liquid formulations of dihydropyridines |
| GB2160100A (en) * | 1984-06-14 | 1985-12-18 | Sandoz Ltd | Galenical retard formulations |
| EP0165450A3 (de) * | 1984-05-23 | 1986-03-12 | Bayer Ag | Nifedipinkombinationspräparate und Verfahren zu ihrer Herstellung |
| EP0164588A3 (de) * | 1984-05-23 | 1986-03-19 | Bayer Ag | Dihydropyridinpräparate und Verfahren zu ihrer Herstellung |
| EP0164587A3 (de) * | 1984-05-23 | 1986-03-19 | Bayer Ag | Nifedipinpräparate und Verfahren zu ihrer Herstellung |
| EP0163984A3 (de) * | 1984-05-23 | 1986-03-19 | Bayer Ag | Dihydropyridinkombinationspräparate und Verfahren zu ihrer Herstellung |
| DE3438830A1 (de) * | 1984-10-23 | 1986-04-30 | Rentschler Arzneimittel | Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung |
| US4880623A (en) * | 1985-10-15 | 1989-11-14 | Eurand Italia S.P.A. | Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained |
| US5158944A (en) * | 1989-03-01 | 1992-10-27 | Teijin Limited | Solid pharmaceutical preparations of active form of vitamin d3 of improved stability |
| US5264446A (en) * | 1980-09-09 | 1993-11-23 | Bayer Aktiengesellschaft | Solid medicament formulations containing nifedipine, and processes for their preparation |
| US5594013A (en) * | 1992-01-13 | 1997-01-14 | Ethical Pharmaceuticals Limited | Pharmaceutical compositions containing nifedipine and process for the preparation thereof |
| US5837379A (en) * | 1997-01-31 | 1998-11-17 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
| US5879714A (en) * | 1996-04-24 | 1999-03-09 | Bernard Charles Sherman | Controlled-release pharmaceutical compositions |
| US5922352A (en) * | 1997-01-31 | 1999-07-13 | Andrx Pharmaceuticals, Inc. | Once daily calcium channel blocker tablet having a delayed release core |
| US6485748B1 (en) | 1997-12-12 | 2002-11-26 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
| RU2245135C1 (ru) * | 2003-09-02 | 2005-01-27 | Открытое акционерное общество "Красфарма" | Способ получения раствора метронидазола для инъекций |
| WO2009032246A3 (en) * | 2007-09-03 | 2009-04-23 | Nanotherapeutics Inc | Particulate compositions for delivery of poorly soluble drugs |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5332110A (en) * | 1976-09-03 | 1978-03-27 | Yamanouchi Pharmaceut Co Ltd | Pharmaceutical composition containing gamma-oryzanol |
| JPS5420127A (en) * | 1977-07-14 | 1979-02-15 | Yamanouchi Pharmaceut Co Ltd | Solid nifedipine preparaton |
| JPS542316A (en) * | 1977-06-07 | 1979-01-09 | Yamanouchi Pharmaceut Co Ltd | Solid pharmaceutical composition containing nifedipene |
| EP0001247A1 (en) * | 1977-09-14 | 1979-04-04 | Kanebo, Ltd. | Pharmaceutical preparation containing nifedipine and a method for producing the same. |
| DE2966564D1 (en) * | 1978-11-20 | 1984-02-23 | American Home Prod | Therapeutic compositions with enhanced bioavailability and process for their preparation |
| CA1146866A (en) | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| JPS56110612A (en) * | 1980-02-08 | 1981-09-01 | Yamanouchi Pharmaceut Co Ltd | Readily disintegrable and absorbable compression molded article of slightly soluble drug |
| CA1173751A (en) * | 1980-05-07 | 1984-09-04 | Jack H. Lazarus | Methoxsalen dosage forms |
| JPS57167911A (en) * | 1981-04-09 | 1982-10-16 | Kyoto Yakuhin Kogyo Kk | Liquid pharmaceutical of nifedipine |
| JPS58206533A (ja) * | 1982-05-27 | 1983-12-01 | Teijin Ltd | 活性型ビタミンｄ↓３誘導体組成物及びそれを活性成分とする薬剤 |
| JPS58146506A (ja) * | 1983-01-13 | 1983-09-01 | バイエル・アクチエンゲゼルシヤフト | ニフエジピン含有固形製剤 |
| AT385654B (de) * | 1984-09-04 | 1988-05-10 | Arcana Chem Pharm | Verfahren zur herstellung von oelhaeltigen zubereitungen in granulatform zur oralen verabreichung |
| WO1987000428A1 (en) * | 1985-07-24 | 1987-01-29 | Pyare Seth | Oxazepam containing pharmaceutical composition |
| US5800834A (en) * | 1996-06-10 | 1998-09-01 | Spireas; Spiridon | Liquisolid systems and methods of preparing same |
-
1974
- 1974-01-09 DE DE19742400819 patent/DE2400819C2/de not_active Expired
-
1975
- 1975-01-06 NL NL7500116A patent/NL7500116A/xx not_active Application Discontinuation
- 1975-01-07 AT AT6375A patent/AT338432B/de not_active IP Right Cessation
- 1975-01-08 GB GB77475A patent/GB1456618A/en not_active Expired
- 1975-01-08 BE BE152215A patent/BE824186A/xx unknown
- 1975-01-09 FR FR7500595A patent/FR2256765B1/fr not_active Expired
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4412986A (en) | 1977-06-07 | 1983-11-01 | Yamanouchi Pharmaceutical Co. Ltd. | Nifedipine-containing solid preparation composition |
| US4344934A (en) * | 1978-11-20 | 1982-08-17 | American Home Products Corporation | Therapeutic compositions with enhanced bioavailability |
| US4411882A (en) | 1978-12-21 | 1983-10-25 | Sandoz Ltd. | Galenical compositions |
| US5264446A (en) * | 1980-09-09 | 1993-11-23 | Bayer Aktiengesellschaft | Solid medicament formulations containing nifedipine, and processes for their preparation |
| JPS5750913A (en) * | 1980-09-09 | 1982-03-25 | Bayer Ag | Nifedipin-containing solid medicine and manufacture |
| EP0047899A1 (de) * | 1980-09-09 | 1982-03-24 | Bayer Ag | Feste Arzneizubereitungen enthaltend Nifedipin und Verfahren zu ihrer Herstellung |
| US4537898A (en) * | 1983-03-03 | 1985-08-27 | Bayer Aktiengesellschaft | Liquid formulations of dihydropyridines |
| EP0164587A3 (de) * | 1984-05-23 | 1986-03-19 | Bayer Ag | Nifedipinpräparate und Verfahren zu ihrer Herstellung |
| EP0164588A3 (de) * | 1984-05-23 | 1986-03-19 | Bayer Ag | Dihydropyridinpräparate und Verfahren zu ihrer Herstellung |
| EP0165450A3 (de) * | 1984-05-23 | 1986-03-12 | Bayer Ag | Nifedipinkombinationspräparate und Verfahren zu ihrer Herstellung |
| EP0163984A3 (de) * | 1984-05-23 | 1986-03-19 | Bayer Ag | Dihydropyridinkombinationspräparate und Verfahren zu ihrer Herstellung |
| GB2160100A (en) * | 1984-06-14 | 1985-12-18 | Sandoz Ltd | Galenical retard formulations |
| DE3438830A1 (de) * | 1984-10-23 | 1986-04-30 | Rentschler Arzneimittel | Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung |
| US4880623A (en) * | 1985-10-15 | 1989-11-14 | Eurand Italia S.P.A. | Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained |
| US5158944A (en) * | 1989-03-01 | 1992-10-27 | Teijin Limited | Solid pharmaceutical preparations of active form of vitamin d3 of improved stability |
| US5594013A (en) * | 1992-01-13 | 1997-01-14 | Ethical Pharmaceuticals Limited | Pharmaceutical compositions containing nifedipine and process for the preparation thereof |
| US5879714A (en) * | 1996-04-24 | 1999-03-09 | Bernard Charles Sherman | Controlled-release pharmaceutical compositions |
| US5837379A (en) * | 1997-01-31 | 1998-11-17 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
| US5922352A (en) * | 1997-01-31 | 1999-07-13 | Andrx Pharmaceuticals, Inc. | Once daily calcium channel blocker tablet having a delayed release core |
| US6485748B1 (en) | 1997-12-12 | 2002-11-26 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
| RU2245135C1 (ru) * | 2003-09-02 | 2005-01-27 | Открытое акционерное общество "Красфарма" | Способ получения раствора метронидазола для инъекций |
| WO2009032246A3 (en) * | 2007-09-03 | 2009-04-23 | Nanotherapeutics Inc | Particulate compositions for delivery of poorly soluble drugs |
| US8377479B2 (en) | 2007-09-03 | 2013-02-19 | Nanotherapeutics, Inc. | Compositions and methods for delivery of poorly soluble drugs |
| AU2008296971B2 (en) * | 2007-09-03 | 2014-10-02 | Nanoshift, Llc | Particulate compositions for delivery of poorly soluble drugs |
| US9554996B2 (en) | 2007-09-03 | 2017-01-31 | Nanotherapeutics, Inc. | Compositions and methods for delivery of poorly soluble drugs |
Also Published As
| Publication number | Publication date |
|---|---|
| BE824186A (fr) | 1975-07-08 |
| NL7500116A (nl) | 1975-07-11 |
| ATA6375A (de) | 1976-12-15 |
| AT338432B (de) | 1977-08-25 |
| DE2400819A1 (de) | 1975-07-17 |
| FR2256765B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-09-22 |
| FR2256765A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-08-01 |
| DE2400819C2 (de) | 1982-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |