GB1451477A - Phenylamidinourea derivatives processes for their preparation and compositions incorporating them - Google Patents
Phenylamidinourea derivatives processes for their preparation and compositions incorporating themInfo
- Publication number
- GB1451477A GB1451477A GB4465473A GB4465473A GB1451477A GB 1451477 A GB1451477 A GB 1451477A GB 4465473 A GB4465473 A GB 4465473A GB 4465473 A GB4465473 A GB 4465473A GB 1451477 A GB1451477 A GB 1451477A
- Authority
- GB
- United Kingdom
- Prior art keywords
- halogen
- lower alkyl
- preparation
- halogen atom
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AGHVRRGALWGXOR-UHFFFAOYSA-N [amino(anilino)methylidene]urea Chemical class NC(=O)NC(=N)NC1=CC=CC=C1 AGHVRRGALWGXOR-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- QRJZGVVKGFIGLI-UHFFFAOYSA-N 2-phenylguanidine Chemical class NC(=N)NC1=CC=CC=C1 QRJZGVVKGFIGLI-UHFFFAOYSA-N 0.000 abstract 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29147472A | 1972-09-22 | 1972-09-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1451477A true GB1451477A (en) | 1976-10-06 |
Family
ID=23120445
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4465473A Expired GB1451477A (en) | 1972-09-22 | 1973-09-24 | Phenylamidinourea derivatives processes for their preparation and compositions incorporating them |
| GB2491476A Expired GB1451479A (en) | 1972-09-22 | 1973-09-24 | Phenylamidourea derivatives and processes for their preparation |
| GB2499276A Expired GB1451480A (en) | 1972-09-22 | 1973-09-24 | Processes for the preparation os substituted phenylguanidines and the compounds thus prepared |
| GB3221175A Expired GB1451478A (en) | 1972-09-22 | 1973-09-24 | Phenylguanidine derivatives and processes for their preparation |
| GB23574/75A Expired GB1514198A (en) | 1972-09-22 | 1975-05-30 | Substituted phenylguanidine compounds processes for their preparation and pharmaceutical compositions containing the same |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2491476A Expired GB1451479A (en) | 1972-09-22 | 1973-09-24 | Phenylamidourea derivatives and processes for their preparation |
| GB2499276A Expired GB1451480A (en) | 1972-09-22 | 1973-09-24 | Processes for the preparation os substituted phenylguanidines and the compounds thus prepared |
| GB3221175A Expired GB1451478A (en) | 1972-09-22 | 1973-09-24 | Phenylguanidine derivatives and processes for their preparation |
| GB23574/75A Expired GB1514198A (en) | 1972-09-22 | 1975-05-30 | Substituted phenylguanidine compounds processes for their preparation and pharmaceutical compositions containing the same |
Country Status (14)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4220658A (en) * | 1972-09-22 | 1980-09-02 | William H. Rorer, Inc. | Treatment of hypertension with amidinoureas |
| US4488993A (en) * | 1972-09-22 | 1984-12-18 | William H. Rorer, Inc. | Amidinoureas |
| US4025652A (en) * | 1975-03-31 | 1977-05-24 | William H. Rorer, Inc. | Amidinoureas |
| US4326074A (en) | 1972-09-22 | 1982-04-20 | William H. Rorer, Inc. | Amidinoureas |
| US4713382A (en) * | 1985-05-30 | 1987-12-15 | Syntex (U.S.A.) Inc. | N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents |
| EP0612723B1 (de) * | 1993-02-20 | 1997-08-27 | Hoechst Aktiengesellschaft | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament |
| RU2156759C1 (ru) * | 2000-01-24 | 2000-09-27 | Совместное предприятие Закрытое акционерное общество "Пронова" | Способ получения n, n'-дифенилгуанидина |
-
1973
- 1973-09-10 PH PH15001A patent/PH12016A/en unknown
- 1973-09-12 DE DE2345951A patent/DE2345951C2/de not_active Expired
- 1973-09-13 CA CA181,015A patent/CA1041908A/en not_active Expired
- 1973-09-17 CH CH1330773A patent/CH605703A5/xx not_active IP Right Cessation
- 1973-09-17 CH CH1605977A patent/CH614430A5/xx not_active IP Right Cessation
- 1973-09-20 AR AR250179A patent/AR200024A1/es active
- 1973-09-21 BE BE135886A patent/BE805138A/xx not_active IP Right Cessation
- 1973-09-21 ES ES418987A patent/ES418987A1/es not_active Expired
- 1973-09-21 JP JP48107418A patent/JPS593471B2/ja not_active Expired
- 1973-09-21 NL NL7313040A patent/NL7313040A/xx not_active Application Discontinuation
- 1973-09-21 ZA ZA737475A patent/ZA737475B/xx unknown
- 1973-09-21 SE SE7312880A patent/SE416952B/xx unknown
- 1973-09-21 FR FR7333963A patent/FR2200002B1/fr not_active Expired
- 1973-09-21 IL IL43280A patent/IL43280A/en unknown
- 1973-09-24 GB GB4465473A patent/GB1451477A/en not_active Expired
- 1973-09-24 GB GB2491476A patent/GB1451479A/en not_active Expired
- 1973-09-24 GB GB2499276A patent/GB1451480A/en not_active Expired
- 1973-09-24 GB GB3221175A patent/GB1451478A/en not_active Expired
-
1975
- 1975-05-30 GB GB23574/75A patent/GB1514198A/en not_active Expired
-
1976
- 1976-11-02 SE SE7612176A patent/SE416953B/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2345951C2 (de) | 1986-10-23 |
| IL43280A0 (en) | 1973-11-28 |
| FR2200002A1 (enrdf_load_stackoverflow) | 1974-04-19 |
| BE805138A (fr) | 1974-01-16 |
| ES418987A1 (es) | 1976-07-01 |
| NL7313040A (enrdf_load_stackoverflow) | 1974-03-26 |
| IL43280A (en) | 1977-06-30 |
| GB1514198A (en) | 1978-06-14 |
| CH605703A5 (enrdf_load_stackoverflow) | 1978-10-13 |
| GB1451479A (en) | 1976-10-06 |
| SE7612176L (sv) | 1976-11-02 |
| AU6047973A (en) | 1975-03-20 |
| CH614430A5 (en) | 1979-11-30 |
| ZA737475B (en) | 1974-10-30 |
| SE416952B (sv) | 1981-02-16 |
| FR2200002B1 (enrdf_load_stackoverflow) | 1977-07-15 |
| JPS593471B2 (ja) | 1984-01-24 |
| DE2345951A1 (de) | 1974-04-04 |
| GB1451478A (en) | 1976-10-06 |
| AR200024A1 (es) | 1974-10-15 |
| CA1041908A (en) | 1978-11-07 |
| PH12016A (en) | 1978-10-06 |
| SE416953B (sv) | 1981-02-16 |
| GB1451480A (en) | 1976-10-06 |
| JPS4985046A (enrdf_load_stackoverflow) | 1974-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES391299A1 (es) | Procedimiento para la preparacion de n-alil 2 - arilamino -imidazolinas (2) sustituidas. | |
| ES431056A1 (es) | Procedimiento para la preparacion de nuevos n- (metoximetil-furilmetil)-6, 7-benzomorfanos y -morfinanos. | |
| GB1451477A (en) | Phenylamidinourea derivatives processes for their preparation and compositions incorporating them | |
| GB1425354A (en) | Indole derivatives | |
| GB1364403A (en) | 1 - aminosulphonyl - 2 - aminobenzimidazoles process for their preparation and their fungicidal use | |
| ES368497A1 (es) | Procedimiento para la preparacion de 2 - aril - amino - i- midazolinas - (2) trisustituidas. | |
| ES390163A1 (es) | Procedimiento para la preparacion de amino-derivados de los acidos pirazolo (3,4-b) piridina-5-carboxilicos. | |
| ES423233A1 (es) | Procedimiento para la preparacion de nuevas 2-fenilamino- imidazolinas-(2) sustituidas. | |
| GB1435476A (en) | Thiazole derivatives processes for their preparation and compositions incorporating them | |
| GB1505020A (en) | Substituted 2-phenylimino-thiazolines a process for their preparation and their use as ectoparasiticides | |
| ES419019A1 (es) | Procedimiento para la preparacion de compuestos polici- clicos. | |
| ES430587A1 (es) | Procedimiento para la preparacion de 4 amino-3,5-dihalogeno-feniletanolaminas. | |
| GB1501795A (en) | Phenylsulphonyl formamidine derivatives and their preparation and use | |
| ES451375A1 (es) | Procedimiento para la preparacion de 2-4 diamino-5-bencil-pirimidinas. | |
| ES290193A1 (es) | Procedimiento de preparaciën de n-(sulfobenzoil) n-desulfoheparinas | |
| GB1511475A (en) | Hydrazinopyridazine derivatives having antihypertensive activity | |
| GB1264944A (enrdf_load_stackoverflow) | ||
| GB1481648A (en) | Substituted triphenylethylenes | |
| ES392665A1 (es) | Un procedimiento para preparar derivados de benzodiazepina-1-sustituidos y sales de los mismos. | |
| FR2402651A1 (fr) | Nouveau procede de preparation de derives de l'oxadiazole | |
| GB921520A (en) | 4-fluoro and 4-bromo-3-sulphamylbenzanilides | |
| GB1097951A (en) | A process for the manufacture of benzdiaz[1,4]epine derivatives | |
| GB1024385A (en) | Khellin derivatives | |
| ES394695A1 (es) | Procedimiento para la preparacion de derivados aminoaceti- licos de 2,3-difenil-ciclopropilamina. | |
| GB1063884A (en) | Sulphanilylaminopyridazinone derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |