GB1449802A - Piperazine derivatives and compositions containing them for treating parkinsons disease - Google Patents
Piperazine derivatives and compositions containing them for treating parkinsons diseaseInfo
- Publication number
- GB1449802A GB1449802A GB453675A GB453675A GB1449802A GB 1449802 A GB1449802 A GB 1449802A GB 453675 A GB453675 A GB 453675A GB 453675 A GB453675 A GB 453675A GB 1449802 A GB1449802 A GB 1449802A
- Authority
- GB
- United Kingdom
- Prior art keywords
- piperazine
- naphthylmethyl
- substituted
- chloromethylnaphthalene
- piperazines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000018737 Parkinson disease Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229910010082 LiAlH Inorganic materials 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US440431A US3919230A (en) | 1974-02-07 | 1974-02-07 | {62 -Naphthylmethyl piperazinyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1449802A true GB1449802A (en) | 1976-09-15 |
Family
ID=23748733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB453675A Expired GB1449802A (en) | 1974-02-07 | 1975-02-03 | Piperazine derivatives and compositions containing them for treating parkinsons disease |
Country Status (16)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4130646A (en) * | 1975-07-25 | 1978-12-19 | E. R. Squibb & Sons, Inc. | 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof |
| JPS52133993A (en) * | 1976-04-29 | 1977-11-09 | Takeda Chem Ind Ltd | 1.2-dihydronaphthalene derivatives and method of preparing the same |
| US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
| US4620006A (en) * | 1982-08-11 | 1986-10-28 | Eastman Kodak Company | Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines |
| JP2002542155A (ja) * | 1999-03-03 | 2002-12-10 | メルク エンド カムパニー インコーポレーテッド | プレニル蛋白トランスフェラーゼの阻害剤 |
| CN107652156B (zh) * | 2017-11-18 | 2023-11-10 | 辽宁科技学院 | 一种β-甲基萘的结晶方法和装置 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL127996C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1963-11-19 |
-
1974
- 1974-02-07 US US440431A patent/US3919230A/en not_active Expired - Lifetime
-
1975
- 1975-01-09 ZA ZA00750160A patent/ZA75160B/xx unknown
- 1975-02-03 CA CA219,288A patent/CA1042434A/en not_active Expired
- 1975-02-03 GB GB453675A patent/GB1449802A/en not_active Expired
- 1975-02-03 AU AU77840/75A patent/AU501049B2/en not_active Expired
- 1975-02-03 JP JP50014791A patent/JPS50108278A/ja active Pending
- 1975-02-04 IL IL46568A patent/IL46568A/xx unknown
- 1975-02-04 CH CH132675A patent/CH616678A5/de not_active IP Right Cessation
- 1975-02-04 ES ES434433A patent/ES434433A1/es not_active Expired
- 1975-02-04 BE BE153056A patent/BE825178A/xx not_active IP Right Cessation
- 1975-02-05 NL NL7501362A patent/NL7501362A/xx not_active Application Discontinuation
- 1975-02-05 FR FR7503627A patent/FR2260353B1/fr not_active Expired
- 1975-02-06 LU LU71803A patent/LU71803A1/xx unknown
- 1975-02-06 DE DE19752505002 patent/DE2505002A1/de not_active Ceased
- 1975-02-07 IE IE254/75A patent/IE40593B1/xx unknown
- 1975-02-07 HU HU75SI00001455A patent/HU171352B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE40593L (en) | 1975-08-07 |
| CA1042434A (en) | 1978-11-14 |
| NL7501362A (nl) | 1975-08-11 |
| AU501049B2 (en) | 1979-06-07 |
| JPS50108278A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-08-26 |
| LU71803A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-06-24 |
| CH616678A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-04-15 |
| ES434433A1 (es) | 1976-11-16 |
| BE825178A (fr) | 1975-08-04 |
| US3919230A (en) | 1975-11-11 |
| ZA75160B (en) | 1976-01-28 |
| FR2260353B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-01-04 |
| FR2260353A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-09-05 |
| IL46568A0 (en) | 1975-04-25 |
| IL46568A (en) | 1979-01-31 |
| DE2505002A1 (de) | 1975-08-14 |
| IE40593B1 (en) | 1979-07-04 |
| AU7784075A (en) | 1976-08-05 |
| HU171352B (hu) | 1977-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |