GB1449586A - Naphthoylamino alkyl phenoxy-alkyl-carboxylic acid derivatives - Google Patents
Naphthoylamino alkyl phenoxy-alkyl-carboxylic acid derivativesInfo
- Publication number
- GB1449586A GB1449586A GB448375A GB448375A GB1449586A GB 1449586 A GB1449586 A GB 1449586A GB 448375 A GB448375 A GB 448375A GB 448375 A GB448375 A GB 448375A GB 1449586 A GB1449586 A GB 1449586A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- prepared
- ethyl
- compound
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical compound NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 abstract 2
- UOBYKYZJUGYBDK-UHFFFAOYSA-N 2-naphthoic acid Chemical compound C1=CC=CC2=CC(C(=O)O)=CC=C21 UOBYKYZJUGYBDK-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- LNETULKMXZVUST-UHFFFAOYSA-N 1-naphthoic acid Chemical compound C1=CC=C2C(C(=O)O)=CC=CC2=C1 LNETULKMXZVUST-UHFFFAOYSA-N 0.000 abstract 1
- -1 4 - Hydroxyphenyl - methyl Chemical group 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XNLBCXGRQWUJLU-UHFFFAOYSA-N naphthalene-2-carbonyl chloride Chemical compound C1=CC=CC2=CC(C(=O)Cl)=CC=C21 XNLBCXGRQWUJLU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 238000005809 transesterification reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742405622 DE2405622A1 (de) | 1974-02-06 | 1974-02-06 | Neue phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1449586A true GB1449586A (en) | 1976-09-15 |
Family
ID=5906747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB448375A Expired GB1449586A (en) | 1974-02-06 | 1975-02-03 | Naphthoylamino alkyl phenoxy-alkyl-carboxylic acid derivatives |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS50108249A (cs) |
| AR (1) | AR203228A1 (cs) |
| AT (1) | AT335439B (cs) |
| BE (1) | BE825176A (cs) |
| CA (1) | CA1043806A (cs) |
| DD (1) | DD120015A5 (cs) |
| DE (1) | DE2405622A1 (cs) |
| DK (1) | DK36575A (cs) |
| ES (1) | ES434446A1 (cs) |
| FI (1) | FI750292A (cs) |
| FR (1) | FR2259597B1 (cs) |
| GB (1) | GB1449586A (cs) |
| HU (1) | HU169491B (cs) |
| IE (1) | IE40585B1 (cs) |
| IL (1) | IL46543A0 (cs) |
| NL (1) | NL7501220A (cs) |
| SE (1) | SE7501083L (cs) |
| SU (1) | SU674670A3 (cs) |
| ZA (1) | ZA75703B (cs) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2038254A2 (en) * | 2006-06-29 | 2009-03-25 | Kinex Pharmaceuticals, LLC | Bicyclic compositions and methods for modulating a kinase cascade |
| WO2012003145A3 (en) * | 2010-07-02 | 2012-05-03 | Allergan, Inc. | Therapeutic agents for ocular hypertension |
| US9714238B2 (en) | 2010-07-02 | 2017-07-25 | Allergan, Inc. | Therapeutic agents for ocular hypertension |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1812315A1 (de) * | 1967-12-28 | 1969-12-04 | Nippon Electric Co | Elektromechanische Schwingungseinrichtung |
| US4214094A (en) | 1977-03-30 | 1980-07-22 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-phenyl substituted-alkyl ethers and the preparation thereof |
| DE2809377A1 (de) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| JPS5649906B2 (en) * | 1978-05-12 | 1981-11-25 | Boehringer Mannheim Gmbh | Manufacture of alphaa*44*44chlorobenzoylaminoo ethyl**phenoxy**isoethylacetic acid |
| US8158650B2 (en) * | 2006-10-23 | 2012-04-17 | Pfizer Inc. | Substituted phenylmethyl bicyclocarboxyamide compounds |
-
1974
- 1974-02-06 DE DE19742405622 patent/DE2405622A1/de not_active Withdrawn
-
1975
- 1975-01-29 CA CA218,899A patent/CA1043806A/en not_active Expired
- 1975-01-31 SE SE7501083A patent/SE7501083L/xx unknown
- 1975-02-03 DD DD183967A patent/DD120015A5/xx unknown
- 1975-02-03 NL NL7501220A patent/NL7501220A/xx unknown
- 1975-02-03 DK DK36575*#A patent/DK36575A/da unknown
- 1975-02-03 FI FI750292A patent/FI750292A/fi not_active Application Discontinuation
- 1975-02-03 IL IL46543A patent/IL46543A0/xx unknown
- 1975-02-03 GB GB448375A patent/GB1449586A/en not_active Expired
- 1975-02-04 BE BE153054A patent/BE825176A/xx unknown
- 1975-02-04 ES ES434446A patent/ES434446A1/es not_active Expired
- 1975-02-04 ZA ZA00750703A patent/ZA75703B/xx unknown
- 1975-02-05 AT AT85775*#A patent/AT335439B/de not_active IP Right Cessation
- 1975-02-05 IE IE231/75A patent/IE40585B1/xx unknown
- 1975-02-05 SU SU752104685A patent/SU674670A3/ru active
- 1975-02-05 FR FR7503585A patent/FR2259597B1/fr not_active Expired
- 1975-02-05 HU HUBO1533A patent/HU169491B/hu unknown
- 1975-02-06 AR AR257551A patent/AR203228A1/es active
- 1975-02-06 JP JP50015856A patent/JPS50108249A/ja active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2038254A2 (en) * | 2006-06-29 | 2009-03-25 | Kinex Pharmaceuticals, LLC | Bicyclic compositions and methods for modulating a kinase cascade |
| WO2012003145A3 (en) * | 2010-07-02 | 2012-05-03 | Allergan, Inc. | Therapeutic agents for ocular hypertension |
| US8633220B2 (en) | 2010-07-02 | 2014-01-21 | Allergan, Inc. | Therapeutic agents for ocular hypertension |
| US9714238B2 (en) | 2010-07-02 | 2017-07-25 | Allergan, Inc. | Therapeutic agents for ocular hypertension |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS50108249A (cs) | 1975-08-26 |
| CA1043806A (en) | 1978-12-05 |
| SU674670A3 (ru) | 1979-07-15 |
| FR2259597B1 (cs) | 1980-01-04 |
| AR203228A1 (es) | 1975-08-22 |
| ZA75703B (en) | 1976-02-25 |
| DK36575A (cs) | 1975-10-06 |
| FI750292A (cs) | 1975-08-07 |
| ATA85775A (de) | 1976-07-15 |
| NL7501220A (nl) | 1975-08-08 |
| AU7701874A (en) | 1976-07-01 |
| IE40585B1 (en) | 1979-07-04 |
| DE2405622A1 (de) | 1975-08-14 |
| HU169491B (cs) | 1976-12-28 |
| AT335439B (de) | 1977-03-10 |
| DD120015A5 (cs) | 1976-05-20 |
| IL46543A0 (en) | 1975-04-25 |
| SE7501083L (cs) | 1975-08-07 |
| BE825176A (fr) | 1975-08-04 |
| FR2259597A1 (cs) | 1975-08-29 |
| ES434446A1 (es) | 1976-12-16 |
| IE40585L (en) | 1975-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |