GB1446352A - Pharmaceutical compositions - Google Patents

Pharmaceutical compositions

Info

Publication number
GB1446352A
GB1446352A GB4039973A GB4039973A GB1446352A GB 1446352 A GB1446352 A GB 1446352A GB 4039973 A GB4039973 A GB 4039973A GB 4039973 A GB4039973 A GB 4039973A GB 1446352 A GB1446352 A GB 1446352A
Authority
GB
United Kingdom
Prior art keywords
cellulose
pharmaceutical compositions
weight
cholestyramine
dispersing agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4039973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1446352A publication Critical patent/GB1446352A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

1446352 Pharmaceutical compositions MERCK & CO INC 28 Aug 1973 [1 Sept 1972] 40399/73 Heading A5B Oral palatable pharmaceutical compositions for the treatment of hypercholestermia and biliary cirrhosis comprise a coacervate of cholestyramine and a hydrophilic colloid of a cellulose derivative such as sodium carboxymethyl cellulose, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose or hydroxy propyl cellulose. The composition may also contain a water-insoluble dispersing agent such as corn starch, potato starch or a carboxymethyl starch. A preferred composition comprises 8 to 10 parts by weight of cholestyramine, 0.8 to 1.3 parts by weight of dispersing agent and 1 part by weight of hydrophilic colloid. The compositions may be in the form of liquid preparations.
GB4039973A 1972-09-01 1973-08-28 Pharmaceutical compositions Expired GB1446352A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28571972A 1972-09-01 1972-09-01

Publications (1)

Publication Number Publication Date
GB1446352A true GB1446352A (en) 1976-08-18

Family

ID=23095432

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4039973A Expired GB1446352A (en) 1972-09-01 1973-08-28 Pharmaceutical compositions

Country Status (7)

Country Link
CA (1) CA1014472A (en)
DE (1) DE2344090A1 (en)
FR (1) FR2197592B1 (en)
GB (1) GB1446352A (en)
IL (1) IL43022A (en)
NL (1) NL7311319A (en)
ZA (1) ZA736016B (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0190826A2 (en) * 1985-02-05 1986-08-13 Warner-Lambert Company Ingestible aggregate and delivery system incorporating the same
US4790991A (en) * 1985-02-05 1988-12-13 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4797288A (en) * 1984-10-05 1989-01-10 Warner-Lambert Company Novel drug delivery system
US4804548A (en) * 1984-10-05 1989-02-14 Warner-Lambert Company Novel sweetener delivery systems
US4818539A (en) * 1985-02-05 1989-04-04 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4828857A (en) * 1984-10-05 1989-05-09 Warner-Lambert Company Novel sweetener delivery systems
US4843098A (en) * 1985-02-05 1989-06-27 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4851392A (en) * 1985-02-05 1989-07-25 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4931280A (en) * 1988-06-13 1990-06-05 Basf K & F Corporation Edible, baked compositions containing cholestyramine
US5167965A (en) * 1987-02-09 1992-12-01 The Dow Chemical Company Palatable cholestyramine granules, tablets and methods for preparation thereof
US5500190A (en) * 1992-03-20 1996-03-19 The Procter & Gamble Company Anion exchange resin compositions containing almond paste for taste improvement
US5601837A (en) * 1990-12-20 1997-02-11 The Procter & Gamble Company Psyllium cholestyramine compositions with improved palatability

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914084A (en) * 1984-05-09 1990-04-03 Synthetic Blood Corporation Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body
IT1190349B (en) * 1986-06-16 1988-02-16 Prodotti Formenti Srl PHARMACEUTICAL COMPOSITIONS WITH SEQUESTRANT ACTIVITY OF BILE ACIDS CONTAINING COLESTYRAMINE AS THE ACTIVE INGREDIENT, AND PROCEDURE TO PREPARE THEM
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
CA1313135C (en) * 1987-02-09 1993-01-26 The Dow Chemical Company Cholestyramine composition and process for its preparation
ES2052911T3 (en) * 1988-05-04 1994-07-16 Smith Kline French Lab CHEWABLE TABLET.
US5275823A (en) * 1989-04-27 1994-01-04 Smith Kline & French Laboratories Ltd. Pharmaceutical compositions
US5102664A (en) * 1989-07-19 1992-04-07 Day Charles E Good-tasting gritty drug formulations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499960A (en) * 1965-01-25 1970-03-10 Merck & Co Inc Palatable coated particles of an anion exchange resin

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797288A (en) * 1984-10-05 1989-01-10 Warner-Lambert Company Novel drug delivery system
US4828857A (en) * 1984-10-05 1989-05-09 Warner-Lambert Company Novel sweetener delivery systems
US4804548A (en) * 1984-10-05 1989-02-14 Warner-Lambert Company Novel sweetener delivery systems
US4818539A (en) * 1985-02-05 1989-04-04 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4790991A (en) * 1985-02-05 1988-12-13 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4747881A (en) * 1985-02-05 1988-05-31 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
EP0190826A2 (en) * 1985-02-05 1986-08-13 Warner-Lambert Company Ingestible aggregate and delivery system incorporating the same
EP0190826A3 (en) * 1985-02-05 1988-03-09 Warner-Lambert Company Ingestible aggregate and delivery system incorporating the same
US4843098A (en) * 1985-02-05 1989-06-27 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4851392A (en) * 1985-02-05 1989-07-25 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US5167965A (en) * 1987-02-09 1992-12-01 The Dow Chemical Company Palatable cholestyramine granules, tablets and methods for preparation thereof
US4931280A (en) * 1988-06-13 1990-06-05 Basf K & F Corporation Edible, baked compositions containing cholestyramine
US5601837A (en) * 1990-12-20 1997-02-11 The Procter & Gamble Company Psyllium cholestyramine compositions with improved palatability
US5500190A (en) * 1992-03-20 1996-03-19 The Procter & Gamble Company Anion exchange resin compositions containing almond paste for taste improvement

Also Published As

Publication number Publication date
FR2197592B1 (en) 1976-08-13
NL7311319A (en) 1974-03-05
DE2344090A1 (en) 1974-03-21
IL43022A (en) 1976-07-30
ZA736016B (en) 1975-04-30
IL43022A0 (en) 1974-01-14
AU5946073A (en) 1975-02-27
FR2197592A1 (en) 1974-03-29
CA1014472A (en) 1977-07-26

Similar Documents

Publication Publication Date Title
GB1446352A (en) Pharmaceutical compositions
IE820136L (en) Pharmaceutical formulation
GB1405088A (en) Slow release formulation
GB1465347A (en) Composition
IE852593L (en) Compositions containing anthracycline glycosides
GB1343595A (en) Oral contraceptive combination
IL102814A0 (en) Pyrazine derivatives,their preparation and pharmaceutical compositions comprising them
DE2966411D1 (en) Imidazolylvinylethers, their preparation and application as active agent in pharmaceutical and biocidal compositions
AU541725B2 (en) Substituted 1,2,5-oxadiazole-2-oxides as pharmaceutical activ cpds,their use and medicaments containing them
GB1404507A (en) Polysaccharide compositions
JPS54105223A (en) Coating agent for solid medicine
GB1487334A (en) Pharmaceutical preparations comprising lisuride and/or physiologically tolerable salts thereof
GB1464200A (en) Pharmaceutical composition
GB1503402A (en) Orally absorbable sterol glycoside
GB1481411A (en) Pharmaceutical compositions
GB1457546A (en) Pharmaceutical preparations comprising cephalosporin derivatives
ES8200678A1 (en) Dibenzazepine derivatives, their production and pharmaceutical compositions containing them.
GB1483650A (en) Pharmaceutical preparations based on mesterolone
US3526698A (en) Stabilization of levo-3-(3,4-dihydroxyphenyl)-2-methylalanine with sodium bisulfite and sorbitol
GB1453234A (en) Liquid vehicle for pharmaceutical compositions
NL184619B (en) PROCESS FOR THE PREPARATION OF ANTI-BACTERIALLY ACTIVE PHARMACEUTICAL PREPARATIONS AND PROCESS FOR THE PREPARATION OF 5-BENZYL-2,4-DIAMINOPYRIMIDINE DERIVATIVES SUITABLE FOR USE
DE2860691D1 (en) 1,2,4-oxadiazol derivatives, their preparation and application in pharmaceutical compositions
JPS5661311A (en) Thial amide or prolonged pharmaceutical preparation comprising its salt
GB1149648A (en) Sterilisation of solids for use in aqueous suspensions
GB1261989A (en) 5-thiazolecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing the same

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee