IL43022A - An oral pharmaceutical composition containing cholestyramine coacervate - Google Patents

An oral pharmaceutical composition containing cholestyramine coacervate

Info

Publication number
IL43022A
IL43022A IL43022A IL4302273A IL43022A IL 43022 A IL43022 A IL 43022A IL 43022 A IL43022 A IL 43022A IL 4302273 A IL4302273 A IL 4302273A IL 43022 A IL43022 A IL 43022A
Authority
IL
Israel
Prior art keywords
composition
hydrophil
colloid
cellulose
pharmaceutical composition
Prior art date
Application number
IL43022A
Other languages
Hebrew (he)
Other versions
IL43022A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL43022A0 publication Critical patent/IL43022A0/en
Publication of IL43022A publication Critical patent/IL43022A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

Claims (6)

What is claimed is :
1. An oral palatable pharmaceutical composition in the coacervate form comprising a hydrophil ic colloid of cellulosive material and an effective amount of cholestyramine .
2. . A composition of claim 1 wherein the hydrophil ic colloid of cellulosive material is sel ected from the group consisting of methyl cellulose , ethyl cellulose , sodium carboxymethyl cellulose , hydroxyethyl cellulose and hydroxypropyl cellulose .
3. A composition of claim 2 wherein the hydrophil ic colloid of cellulosive materia l is sodium carboxymethyl cel lulose .
4. . A composition of claim 2 further comprising a water-insoluble dispersing agent .
5. A composition of claim 4 wherein the water- insoluble dispersing agent is selected from the group consisting of corn starch, potato starch and a low substituted carboxymethyl starch of the formula :
6. A composition of claim 5 wherein the water- insoluble dispersing agent is a low substituted carboxymethyl starch and the hydrophil ic colloid of cel lulosive material is sodium carboxymethyl cel lulose . For thfc mpp!tcantt
IL43022A 1972-09-01 1973-08-20 An oral pharmaceutical composition containing cholestyramine coacervate IL43022A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28571972A 1972-09-01 1972-09-01

Publications (2)

Publication Number Publication Date
IL43022A0 IL43022A0 (en) 1974-01-14
IL43022A true IL43022A (en) 1976-07-30

Family

ID=23095432

Family Applications (1)

Application Number Title Priority Date Filing Date
IL43022A IL43022A (en) 1972-09-01 1973-08-20 An oral pharmaceutical composition containing cholestyramine coacervate

Country Status (7)

Country Link
CA (1) CA1014472A (en)
DE (1) DE2344090A1 (en)
FR (1) FR2197592B1 (en)
GB (1) GB1446352A (en)
IL (1) IL43022A (en)
NL (1) NL7311319A (en)
ZA (1) ZA736016B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914084A (en) * 1984-05-09 1990-04-03 Synthetic Blood Corporation Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body
US4797288A (en) * 1984-10-05 1989-01-10 Warner-Lambert Company Novel drug delivery system
US4828857A (en) * 1984-10-05 1989-05-09 Warner-Lambert Company Novel sweetener delivery systems
US4804548A (en) * 1984-10-05 1989-02-14 Warner-Lambert Company Novel sweetener delivery systems
US4843098A (en) * 1985-02-05 1989-06-27 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4747881A (en) * 1985-02-05 1988-05-31 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4851392A (en) * 1985-02-05 1989-07-25 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4818539A (en) * 1985-02-05 1989-04-04 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4790991A (en) * 1985-02-05 1988-12-13 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
IT1190349B (en) * 1986-06-16 1988-02-16 Prodotti Formenti Srl PHARMACEUTICAL COMPOSITIONS WITH SEQUESTRANT ACTIVITY OF BILE ACIDS CONTAINING COLESTYRAMINE AS THE ACTIVE INGREDIENT, AND PROCEDURE TO PREPARE THEM
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
CA1313135C (en) * 1987-02-09 1993-01-26 The Dow Chemical Company Cholestyramine composition and process for its preparation
US5167965A (en) * 1987-02-09 1992-12-01 The Dow Chemical Company Palatable cholestyramine granules, tablets and methods for preparation thereof
ATE82680T1 (en) * 1988-05-04 1992-12-15 Smith Kline French Lab CHEWABLE TABLET.
US4931280A (en) * 1988-06-13 1990-06-05 Basf K & F Corporation Edible, baked compositions containing cholestyramine
US5275823A (en) * 1989-04-27 1994-01-04 Smith Kline & French Laboratories Ltd. Pharmaceutical compositions
US5102664A (en) * 1989-07-19 1992-04-07 Day Charles E Good-tasting gritty drug formulations
CA2098199C (en) * 1990-12-20 1997-06-03 Nabil George Kardouche Psyllium and cholestyramine compositions with improved palatability
WO1993018756A1 (en) * 1992-03-20 1993-09-30 The Procter & Gamble Company Anion exchange resin compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499960A (en) * 1965-01-25 1970-03-10 Merck & Co Inc Palatable coated particles of an anion exchange resin

Also Published As

Publication number Publication date
FR2197592B1 (en) 1976-08-13
FR2197592A1 (en) 1974-03-29
NL7311319A (en) 1974-03-05
ZA736016B (en) 1975-04-30
CA1014472A (en) 1977-07-26
AU5946073A (en) 1975-02-27
GB1446352A (en) 1976-08-18
DE2344090A1 (en) 1974-03-21
IL43022A0 (en) 1974-01-14

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