GB1445740A - Ethanolamine derivatives - Google Patents
Ethanolamine derivativesInfo
- Publication number
- GB1445740A GB1445740A GB5834473A GB5834473A GB1445740A GB 1445740 A GB1445740 A GB 1445740A GB 5834473 A GB5834473 A GB 5834473A GB 5834473 A GB5834473 A GB 5834473A GB 1445740 A GB1445740 A GB 1445740A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- action
- groups
- novel
- hydroxyalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Novel aminophenylethanolamines of the accompanying formula I, in which R1 denotes a hydrogen, fluorine, chlorine, bromine or iodine atom or a cyano group; R2 denotes a fluorine atom, a straight-chain or branched alkyl group having 1 to 5 carbon atoms, a hydroxyalkyl, aminoalkyl, dialkylaminoalkyl, trifluoromethyl, alkoxy, nitro, cyano, carboxyl, carbalkoxy or carbamoyl group; R3 and R4, which are identical or different, denote hydrogen atoms, straight-chain or branched alkyl groups having 1 to 6 carbon atoms, hydroxyalkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl or optionally substituted aralkyl groups, are prepared by removing the protective groups from corresponding compounds having protected hydroxy and/or protected amino groups. The novel compounds can be obtained in the form of their racemates or their optically active antipodes. The novel compounds have useful pharmacological properties, in particular ss2-mimetic and/or ss1-blocking actions in addition to an analgesic, uterospasmolytic and an antispastic action on the striated musculature, one or the other action being predominant depending on their substitution. The d-(+) compounds in particular have a selective action on the ss1-receptors and the l-(-) compounds have a preferred action on the ss2-receptors. <IMAGE>
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2261914A DE2261914C3 (en) | 1972-12-18 | 1972-12-18 | Amino-phenyl-ethanolamines and their acid addition salts, processes for their production and pharmaceuticals |
DE19732345442 DE2345442C2 (en) | 1973-09-08 | 1973-09-08 | d- and l-phenylethanolamines and their salts, manufacturing processes and drugs based on them |
DE19732351281 DE2351281C3 (en) | 1973-10-12 | 1973-10-12 | Aminophenylethanolamine derivatives, their production and use |
DE2354961A DE2354961C2 (en) | 1973-11-02 | 1973-11-02 | Process for the preparation of aminophenylethanolamines |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1445740A true GB1445740A (en) | 1976-08-11 |
Family
ID=27431596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5834473A Expired GB1445740A (en) | 1972-12-18 | 1973-12-17 | Ethanolamine derivatives |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS5811852B2 (en) |
KR (1) | KR850001916B1 (en) |
BG (1) | BG21209A3 (en) |
CA (1) | CA1027955A (en) |
CH (2) | CH614188A5 (en) |
DD (1) | DD111574A5 (en) |
DK (1) | DK150502C (en) |
FI (1) | FI62052C (en) |
FR (1) | FR2210414B1 (en) |
GB (1) | GB1445740A (en) |
HK (1) | HK6680A (en) |
HU (1) | HU168701B (en) |
IE (1) | IE39065B1 (en) |
IL (1) | IL43837A (en) |
MY (1) | MY8800145A (en) |
NL (1) | NL176168C (en) |
NO (1) | NO137782C (en) |
PL (1) | PL97194B1 (en) |
RO (1) | RO63025A (en) |
SE (1) | SE409700B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0278727A2 (en) * | 1987-02-10 | 1988-08-17 | Glaxo Group Limited | 1-(4-Amino-3-chloro-5-trifluoromethylphenyl)-2-(substituted amino)ethanol derivatives and their use in the treatment of respiratory disease |
US4921867A (en) * | 1987-02-10 | 1990-05-01 | Glaxo Group Limited | Pyridine compounds useful for therapy or prophylaxis of a disease associated with airway obstruction |
US4937251A (en) * | 1986-02-12 | 1990-06-26 | Glaxo Group Limited | Dichloroaniline compounds useful for method of therapy or prophylaxis of a disease associated with reversible airway obstruction |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2430486A1 (en) * | 1978-07-07 | 1980-02-01 | Oreal | Disinfectant deodorant stick for hanging in WC - is in cage within sealed cartridge which is removed by tearing strip defined by rupture lines |
NL8105170A (en) * | 1980-12-10 | 1982-07-01 | Thomae Gmbh Dr K | NEW PHENYL ALKYLAMINS, METHOD FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICINES. |
FR2515177A1 (en) * | 1981-10-28 | 1983-04-29 | Lafon Labor | 1-Amino:phenyl 2-isopropyl or tert.butyl-amino 1-ethanol derivs. - used as antidepressants, sedatives, vasodilators and hypotensives, without hyper:reactivity and excitation side effects |
GB8426191D0 (en) * | 1984-10-17 | 1984-11-21 | Glaxo Holdings Ltd | Chemical compounds |
US4943591A (en) * | 1984-10-17 | 1990-07-24 | Glaxo Group Limited | Dichloroaniline derivatives |
EP0224001B1 (en) * | 1985-10-17 | 1991-03-20 | American Cyanamid Company | Anthranilonitrile derivatives and related compounds as useful agents for promoting growth, improving feed efficiency, and for increasing the lean meat to fat ratio of warm-blooded animals |
US4863959A (en) * | 1985-10-17 | 1989-09-05 | American Cyanamid Company | Anthranilonitrile derivatives as useful agents for promoting growth, improving feed efficiency, and for increasing the lean meat to fat ratio of warm-blooded animals |
KR100878737B1 (en) * | 2003-08-29 | 2009-01-14 | 미쓰이 가가쿠 가부시키가이샤 | Insecticide for agricultural or horticultural use and method of use thereof |
GB0604822D0 (en) * | 2006-03-09 | 2006-04-19 | Arakis Ltd | The treatment of inflammatory disorders and pain |
CN100497296C (en) * | 2006-07-07 | 2009-06-10 | 沈阳药科大学 | Novel optical activity phenylethanolamine compounds and preparation method thereof |
GB201714734D0 (en) * | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
-
1973
- 1973-11-26 NL NLAANVRAGE7316139,A patent/NL176168C/en not_active IP Right Cessation
- 1973-12-04 BG BG26781A patent/BG21209A3/xx unknown
- 1973-12-10 FI FI3770/73A patent/FI62052C/en active
- 1973-12-14 DD DD175409A patent/DD111574A5/xx unknown
- 1973-12-14 RO RO7300077002A patent/RO63025A/en unknown
- 1973-12-14 CH CH1178977A patent/CH614188A5/en not_active IP Right Cessation
- 1973-12-14 CH CH1755873A patent/CH605622A5/xx not_active IP Right Cessation
- 1973-12-17 SE SE7317035A patent/SE409700B/en unknown
- 1973-12-17 NO NO4814/73A patent/NO137782C/en unknown
- 1973-12-17 HU HUTO949A patent/HU168701B/hu unknown
- 1973-12-17 DK DK684873A patent/DK150502C/en not_active IP Right Cessation
- 1973-12-17 CA CA188,272A patent/CA1027955A/en not_active Expired
- 1973-12-17 PL PL73182408A patent/PL97194B1/en unknown
- 1973-12-17 JP JP48141734A patent/JPS5811852B2/en not_active Expired
- 1973-12-17 GB GB5834473A patent/GB1445740A/en not_active Expired
- 1973-12-17 IL IL43837A patent/IL43837A/en unknown
- 1973-12-18 IE IE2292/73A patent/IE39065B1/en unknown
- 1973-12-18 FR FR7345290A patent/FR2210414B1/fr not_active Expired
-
1975
- 1975-05-19 KR KR7501095A patent/KR850001916B1/en active IP Right Grant
-
1980
- 1980-02-28 HK HK66/80A patent/HK6680A/en unknown
-
1988
- 1988-12-30 MY MY58344/73A patent/MY8800145A/en unknown
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4937251A (en) * | 1986-02-12 | 1990-06-26 | Glaxo Group Limited | Dichloroaniline compounds useful for method of therapy or prophylaxis of a disease associated with reversible airway obstruction |
EP0278727A2 (en) * | 1987-02-10 | 1988-08-17 | Glaxo Group Limited | 1-(4-Amino-3-chloro-5-trifluoromethylphenyl)-2-(substituted amino)ethanol derivatives and their use in the treatment of respiratory disease |
EP0278727A3 (en) * | 1987-02-10 | 1990-03-14 | Glaxo Group Limited | 1-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-(substituted amino)ethanol derivatives and their use in the treatment of respiratory disease |
US4921867A (en) * | 1987-02-10 | 1990-05-01 | Glaxo Group Limited | Pyridine compounds useful for therapy or prophylaxis of a disease associated with airway obstruction |
US4959381A (en) * | 1987-02-10 | 1990-09-25 | Glaxo Group Limited | Pyridine compounds which have useful activity associated with reversible air ways obstruction |
Also Published As
Publication number | Publication date |
---|---|
NL176168C (en) | 1985-03-01 |
DK150502B (en) | 1987-03-16 |
MY8800145A (en) | 1988-12-31 |
AU6369373A (en) | 1975-06-19 |
KR850001916B1 (en) | 1985-12-31 |
CA1027955A (en) | 1978-03-14 |
CH605622A5 (en) | 1978-10-13 |
PL97194B1 (en) | 1978-02-28 |
HU168701B (en) | 1976-06-28 |
FR2210414A1 (en) | 1974-07-12 |
KR830000207A (en) | 1983-03-30 |
NO137782B (en) | 1978-01-16 |
FI62052B (en) | 1982-07-30 |
RO63025A (en) | 1978-12-15 |
DK150502C (en) | 1987-10-26 |
NO137782C (en) | 1978-04-26 |
FI62052C (en) | 1982-11-10 |
JPS5811852B2 (en) | 1983-03-04 |
SE409700B (en) | 1979-09-03 |
IL43837A (en) | 1977-02-28 |
NL7316139A (en) | 1974-06-20 |
NL176168B (en) | 1984-10-01 |
CH614188A5 (en) | 1979-11-15 |
IL43837A0 (en) | 1974-03-14 |
JPS4994640A (en) | 1974-09-09 |
IE39065L (en) | 1974-06-18 |
BG21209A3 (en) | 1976-03-20 |
DD111574A5 (en) | 1975-02-20 |
FR2210414B1 (en) | 1977-01-28 |
HK6680A (en) | 1980-03-07 |
IE39065B1 (en) | 1978-08-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PE20 | Patent expired after termination of 20 years |
Effective date: 19931216 |