ES464553A2 - 5-methyliso-oxazole-4-carboxylic acid anilides having pharmaceutical activity - Google Patents

5-methyliso-oxazole-4-carboxylic acid anilides having pharmaceutical activity

Info

Publication number
ES464553A2
ES464553A2 ES464553A ES464553A ES464553A2 ES 464553 A2 ES464553 A2 ES 464553A2 ES 464553 A ES464553 A ES 464553A ES 464553 A ES464553 A ES 464553A ES 464553 A2 ES464553 A2 ES 464553A2
Authority
ES
Spain
Prior art keywords
carbon atoms
carboxylic acid
denote
methyliso
oxazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES464553A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES464553A2 publication Critical patent/ES464553A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Abstract

Novel 5-methyl-isoxazole-4-carboxylic acid anilides of the formula I < IMAGE > wherein one, two or three of the radicals R1, R2 and R3 denote a carboxyl group and/or a hydroxyl group and the remaining radicals R1, R2 and R3, which may be identical or different, denote alkyl having 1, 2 or 3 carbon atoms, alkoxy having 1, 2 and 3 carbon atoms or alkylthio having 1, 2 or 3 carbon atoms, which groups may each be completely or partially substituted by identical or different halogen atoms, or denote hydrogen, halogen, nitro, cyano or carbalkoxy having 1, 2 or 3 carbon atoms in the alkyl group, are prepared by reacting a 5-methyl-isoxazole-4-carboxylic acid derivative with an appropriately substituted aniline. The compounds of the formula I are pharmacologically active. They exhibit a powerful antiphlogistic, antipyretic and analgesic action. Their toxicity is low and their gastric toleration is good.
ES464553A 1976-12-04 1977-11-29 5-methyliso-oxazole-4-carboxylic acid anilides having pharmaceutical activity Expired ES464553A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762655094 DE2655094A1 (en) 1976-12-04 1976-12-04 ISOXAZOLE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THE PRODUCTS CONTAINING THE SAME

Publications (1)

Publication Number Publication Date
ES464553A2 true ES464553A2 (en) 1979-08-01

Family

ID=5994722

Family Applications (1)

Application Number Title Priority Date Filing Date
ES464553A Expired ES464553A2 (en) 1976-12-04 1977-11-29 5-methyliso-oxazole-4-carboxylic acid anilides having pharmaceutical activity

Country Status (14)

Country Link
JP (1) JPS5371069A (en)
AT (1) AT362788B (en)
BE (1) BE861502R (en)
CA (1) CA1094564A (en)
CH (1) CH614945A5 (en)
DE (1) DE2655094A1 (en)
DK (1) DK538577A (en)
ES (1) ES464553A2 (en)
FR (1) FR2372813A2 (en)
GB (1) GB1595467A (en)
IE (1) IE46102B1 (en)
IT (1) IT1113801B (en)
LU (1) LU78626A1 (en)
NL (1) NL7713148A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035285A3 (en) * 1979-08-17 1981-10-14 American Cyanamid Company Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters
JPS55500866A (en) * 1978-11-03 1980-10-30
DE3247454A1 (en) * 1982-12-22 1984-06-28 Laboratorios Bago S.A., Buenos Aires Substituted 3-phenyl-5-methylisoxazole-4-carboxanilides, process for their preparation and pharmaceutical compositions containing these compounds
FR2538806B1 (en) * 1982-12-30 1986-02-21 Bago Sa Labor PHENYL-3 METHYL ISOXAZOLE-5 CARBOXY-4 COMPOUNDS SUBSTITUTED ANILIDES, THERAPEUTICALLY ACTIVE INFLAMMATION AND PAIN
US20040110802A1 (en) * 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2126329A (en) * 1936-03-20 1938-08-09 Hoffmann La Roche Amide derivatives of isoxazole carboxylic acids
US2288863A (en) * 1940-02-27 1942-07-07 Hoffmann La Roche Process for the manufacture of substituted amides of 3,5-dimethylisoxazole-4-carboxylic acid

Also Published As

Publication number Publication date
FR2372813A2 (en) 1978-06-30
BE861502R (en) 1978-06-05
CH614945A5 (en) 1979-12-28
LU78626A1 (en) 1978-07-11
DE2655094A1 (en) 1978-06-15
FR2372813B2 (en) 1980-06-20
IE46102B1 (en) 1983-02-23
JPS5371069A (en) 1978-06-24
IT1113801B (en) 1986-01-27
CA1094564A (en) 1981-01-27
AT362788B (en) 1981-06-10
IE46102L (en) 1978-06-04
ATA866277A (en) 1980-11-15
DK538577A (en) 1978-06-05
GB1595467A (en) 1981-08-12
NL7713148A (en) 1978-06-06

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100616