KR950000705A - 14-Substituted Morfinan Derivatives and Pharmaceuticals Containing the Same - Google Patents

14-Substituted Morfinan Derivatives and Pharmaceuticals Containing the Same Download PDF

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Publication number
KR950000705A
KR950000705A KR1019930011258A KR930011258A KR950000705A KR 950000705 A KR950000705 A KR 950000705A KR 1019930011258 A KR1019930011258 A KR 1019930011258A KR 930011258 A KR930011258 A KR 930011258A KR 950000705 A KR950000705 A KR 950000705A
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KR
South Korea
Prior art keywords
group
alkyl
substituted
formula
derivatives
Prior art date
Application number
KR1019930011258A
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Korean (ko)
Inventor
김근재
Original Assignee
권기범
강재헌
동국제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 권기범, 강재헌, 동국제약 주식회사 filed Critical 권기범
Priority to KR1019930011258A priority Critical patent/KR950000705A/en
Priority to PCT/KR1994/000075 priority patent/WO1995000518A1/en
Publication of KR950000705A publication Critical patent/KR950000705A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 진통제로서 우수한 하기 일반식(I)와 신규의 유도체에 관한 것이다. 특히 본 발명의 일반식(I) 화합물은 습관성가 독성이 없고 생리활성이 높은 유용한 화합물이다.The present invention relates to the following general formula (I) and novel derivatives which are excellent as analgesics. In particular, the general formula (I) compounds of the present invention are useful compounds having no habitual toxicity and high physiological activity.

상기 식에서 R1은 탄소수 1~4의 알킬, 알릴, 시클로프로필메틸, 알킬이나 니트로등이 치환된 벤질을 나타내며, R2는 트리플루오로메틸, 펜타플루오로에틸 등의 불소 치환 알킬기를 나타내며, R3는 수소원자, 메틸기 또는 에틸기를 나타내며, X 및 Y는 각각 수소 또는 히드록시기를 나타내거나, 또는 X 및 Y가 함께 옥소기를 나타낸다.In the formula, R 1 represents benzyl substituted with alkyl, allyl, cyclopropylmethyl, alkyl or nitro having 1 to 4 carbon atoms, R 2 represents a fluorine substituted alkyl group such as trifluoromethyl, pentafluoroethyl, and R 3 represents a hydrogen atom, a methyl group or an ethyl group, X and Y each represent hydrogen or a hydroxy group, or X and Y together represent an oxo group.

Description

14-치환 몰피난 유도체 및 이를 함유하는 의약14-Substituted Morfinan Derivatives and Pharmaceuticals Containing the Same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

진통효과를 갖는 하기 일반식(I)의 14-치환 몰피난 유도체14-Substituted Morfinan Derivatives of Formula (I) below Having Analgesic Effect 상기 식에서 R1은 탄소수 1~4의 알킬, 알릴, 시클로프로필메틸, 알킬이나 니트로등이 치환된 벤질을 나타내며, R2는 트리플루오로메틸, 펜타플루오로에틸 등의 불소 치환 알킬기를 나타내며, R3는 수소원자, 메틸기 또는 에틸기를 나타내며, X 및 Y는 각각 수소 또는 히드록시기를 나타내거나, 또는 X 및 Y가 함께 옥소기를 나타낸다.In the formula, R 1 represents benzyl substituted with alkyl, allyl, cyclopropylmethyl, alkyl or nitro having 1 to 4 carbon atoms, R 2 represents a fluorine substituted alkyl group such as trifluoromethyl, pentafluoroethyl, and R 3 represents a hydrogen atom, a methyl group or an ethyl group, X and Y each represent hydrogen or a hydroxy group, or X and Y together represent an oxo group. 하기 일반식(I)의 14-치환 몰피난 또는 그의 유도체를 유효성분으로 하는 진통제.An analgesic agent comprising 14-substituted morphinan of the formula (I) or a derivative thereof as an active ingredient. 상기 식에서 R1은 탄소수 1~4의 알킬, 알릴, 시클로프로필메틸, 알킬이나 니트로등이 치환된 벤질을 나타내며, R2는 트리플루오로메틸, 펜타플루오로에틸 등의 불소 치환 알킬기를 나타내며, R3는 수소원자, 메틸기 또는 에틸기를 나타내며, X 및 Y는 각각 수소 또는 히드록시기를 나타내거나, 또는 X 및 Y가 함께 옥소기를 나타낸다.In the formula, R 1 represents benzyl substituted with alkyl, allyl, cyclopropylmethyl, alkyl or nitro having 1 to 4 carbon atoms, R 2 represents a fluorine substituted alkyl group such as trifluoromethyl, pentafluoroethyl, and R 3 represents a hydrogen atom, a methyl group or an ethyl group, X and Y each represent hydrogen or a hydroxy group, or X and Y together represent an oxo group. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930011258A 1993-06-19 1993-06-19 14-Substituted Morfinan Derivatives and Pharmaceuticals Containing the Same KR950000705A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019930011258A KR950000705A (en) 1993-06-19 1993-06-19 14-Substituted Morfinan Derivatives and Pharmaceuticals Containing the Same
PCT/KR1994/000075 WO1995000518A1 (en) 1993-06-19 1994-06-18 14-substituted morphinan derivative and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019930011258A KR950000705A (en) 1993-06-19 1993-06-19 14-Substituted Morfinan Derivatives and Pharmaceuticals Containing the Same

Publications (1)

Publication Number Publication Date
KR950000705A true KR950000705A (en) 1995-01-03

Family

ID=19357701

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930011258A KR950000705A (en) 1993-06-19 1993-06-19 14-Substituted Morfinan Derivatives and Pharmaceuticals Containing the Same

Country Status (2)

Country Link
KR (1) KR950000705A (en)
WO (1) WO1995000518A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010044212A (en) * 2001-01-04 2001-06-05 김창수 Process for producing linear high molecular weight polyphenylene sulfide

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012047832A2 (en) 2010-10-07 2012-04-12 Shell Oil Company Process for the production of alcohols from biomass
EP2635712B1 (en) 2010-11-05 2014-07-02 Shell Oil Company Treating biomass to produce materials useful for biofuels
WO2012088108A1 (en) 2010-12-20 2012-06-28 Shell Oil Company Process for the production of alcohols from biomass
EP3180321A4 (en) 2014-08-14 2018-04-11 Shell International Research Maatschappij B.V. Process for preparing furfural from biomass

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347361A (en) * 1980-12-10 1982-08-31 Sisa, Incorporated 4,5α-Epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-oxoalkyl)morphinan-6-one compounds
US4749706A (en) * 1986-03-24 1988-06-07 Sri International Orally active nonaddicting analgesics
FR2636330B1 (en) * 1988-09-13 1990-11-30 Sanofi Sa PROCESS FOR THE PREPARATION OF MORPHINANE DERIVATIVES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010044212A (en) * 2001-01-04 2001-06-05 김창수 Process for producing linear high molecular weight polyphenylene sulfide

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Publication number Publication date
WO1995000518A1 (en) 1995-01-05

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