GB1445254A - Method for the production of 2,4-diamino-5-3,4,5-trimethoxy benzyl-pyrimidine - Google Patents
Method for the production of 2,4-diamino-5-3,4,5-trimethoxy benzyl-pyrimidineInfo
- Publication number
- GB1445254A GB1445254A GB3898274A GB3898274A GB1445254A GB 1445254 A GB1445254 A GB 1445254A GB 3898274 A GB3898274 A GB 3898274A GB 3898274 A GB3898274 A GB 3898274A GB 1445254 A GB1445254 A GB 1445254A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrimidine
- diamino
- production
- mixture
- trimethoxy benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 abstract 3
- OPHQOIGEOHXOGX-UHFFFAOYSA-N 3,4,5-trimethoxybenzaldehyde Chemical compound COC1=CC(C=O)=CC(OC)=C1OC OPHQOIGEOHXOGX-UHFFFAOYSA-N 0.000 abstract 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 abstract 2
- 229960001082 trimethoprim Drugs 0.000 abstract 2
- SHANJVNUXNVEJC-UHFFFAOYSA-N 2-[(3,4,5-trimethoxyphenyl)methylidene]propanedinitrile Chemical compound COC1=CC(C=C(C#N)C#N)=CC(OC)=C1OC SHANJVNUXNVEJC-UHFFFAOYSA-N 0.000 abstract 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- CUONGYYJJVDODC-UHFFFAOYSA-N malononitrile Chemical compound N#CCC#N CUONGYYJJVDODC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK495873A DK135945B (da) | 1973-09-10 | 1973-09-10 | Fremgangsmåde til fremstilling af 2,4-diamino-5-(3',4',5'-trimetoxybenzyl)-pyrimidin. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1445254A true GB1445254A (en) | 1976-08-11 |
Family
ID=8138184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3898274A Expired GB1445254A (en) | 1973-09-10 | 1974-09-06 | Method for the production of 2,4-diamino-5-3,4,5-trimethoxy benzyl-pyrimidine |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5315518B2 (enrdf_load_stackoverflow) |
| AT (1) | AT340934B (enrdf_load_stackoverflow) |
| CA (1) | CA1016943A (enrdf_load_stackoverflow) |
| CH (1) | CH599943A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2443080C3 (enrdf_load_stackoverflow) |
| DK (1) | DK135945B (enrdf_load_stackoverflow) |
| GB (1) | GB1445254A (enrdf_load_stackoverflow) |
| HK (1) | HK12578A (enrdf_load_stackoverflow) |
| KE (1) | KE2805A (enrdf_load_stackoverflow) |
| NL (1) | NL160553C (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60189686U (ja) * | 1984-05-28 | 1985-12-16 | 井上エムテ−ピ−株式会社 | ク−ルエア−インテ−クホ−ス |
-
1973
- 1973-09-10 DK DK495873A patent/DK135945B/da not_active IP Right Cessation
-
1974
- 1974-09-06 GB GB3898274A patent/GB1445254A/en not_active Expired
- 1974-09-09 CA CA208,719A patent/CA1016943A/en not_active Expired
- 1974-09-09 NL NL7411931A patent/NL160553C/xx not_active IP Right Cessation
- 1974-09-09 AT AT724274A patent/AT340934B/de not_active IP Right Cessation
- 1974-09-09 CH CH1224974A patent/CH599943A5/xx not_active IP Right Cessation
- 1974-09-09 DE DE19742443080 patent/DE2443080C3/de not_active Expired
- 1974-09-09 JP JP10307874A patent/JPS5315518B2/ja not_active Expired
-
1977
- 1977-11-29 KE KE280577A patent/KE2805A/xx unknown
-
1978
- 1978-03-02 HK HK12578A patent/HK12578A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK495873A (enrdf_load_stackoverflow) | 1975-05-12 |
| KE2805A (en) | 1978-01-06 |
| DK135945B (da) | 1977-07-18 |
| HK12578A (en) | 1978-03-10 |
| NL160553B (nl) | 1979-06-15 |
| JPS5315518B2 (enrdf_load_stackoverflow) | 1978-05-25 |
| JPS50116483A (enrdf_load_stackoverflow) | 1975-09-11 |
| CH599943A5 (enrdf_load_stackoverflow) | 1978-06-15 |
| NL7411931A (nl) | 1975-03-12 |
| DE2443080B2 (de) | 1977-08-04 |
| NL160553C (nl) | 1979-11-15 |
| AT340934B (de) | 1978-01-10 |
| DK135945C (enrdf_load_stackoverflow) | 1979-09-17 |
| CA1016943A (en) | 1977-09-06 |
| DE2443080A1 (de) | 1975-03-20 |
| ATA724274A (de) | 1977-05-15 |
| DE2443080C3 (de) | 1979-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |