GB1445236A - Process for the preparation of 25-hydroxycholesterol and 3- alkanoyloxy derivatives thereof and pregnanes useful therein - Google Patents

Process for the preparation of 25-hydroxycholesterol and 3- alkanoyloxy derivatives thereof and pregnanes useful therein

Info

Publication number
GB1445236A
GB1445236A GB2247174A GB2247174A GB1445236A GB 1445236 A GB1445236 A GB 1445236A GB 2247174 A GB2247174 A GB 2247174A GB 2247174 A GB2247174 A GB 2247174A GB 1445236 A GB1445236 A GB 1445236A
Authority
GB
United Kingdom
Prior art keywords
compounds
hydroxycholesterol
xii
formula
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2247174A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1445236A publication Critical patent/GB1445236A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB2247174A 1973-05-21 1974-05-20 Process for the preparation of 25-hydroxycholesterol and 3- alkanoyloxy derivatives thereof and pregnanes useful therein Expired GB1445236A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00362569A US3822254A (en) 1973-05-21 1973-05-21 Synthesis of 25-hydroxycholesterol

Publications (1)

Publication Number Publication Date
GB1445236A true GB1445236A (en) 1976-08-04

Family

ID=23426617

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2247174A Expired GB1445236A (en) 1973-05-21 1974-05-20 Process for the preparation of 25-hydroxycholesterol and 3- alkanoyloxy derivatives thereof and pregnanes useful therein
GB4033475A Expired GB1445237A (en) 1973-05-21 1974-05-20 25-hydroxycholestanes 25-hydroxycholestynes their preparation and use in the production of 25-hydroxycholesterol and 3- alkanoyloxy derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB4033475A Expired GB1445237A (en) 1973-05-21 1974-05-20 25-hydroxycholestanes 25-hydroxycholestynes their preparation and use in the production of 25-hydroxycholesterol and 3- alkanoyloxy derivatives

Country Status (9)

Country Link
US (1) US3822254A (https=)
JP (1) JPS5614679B2 (https=)
AT (1) AT343294B (https=)
BE (1) BE815252A (https=)
CH (1) CH617442A5 (https=)
DE (1) DE2424498C3 (https=)
FR (1) FR2236854B1 (https=)
GB (2) GB1445236A (https=)
NL (1) NL172956C (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5218700B2 (https=) * 1973-02-16 1977-05-24
US3928397A (en) * 1973-03-02 1975-12-23 Eisai Co Ltd New 5-cholestene derivatives and preparation thereof
US3959320A (en) * 1974-09-23 1976-05-25 The Upjohn Company Process and compounds
US3976636A (en) * 1974-10-10 1976-08-24 The Upjohn Company Process and compounds
US3994934A (en) * 1975-01-27 1976-11-30 The Upjohn Company Process for preparing Δ22 -25-oxy substituted sterol derivatives
US4264512A (en) * 1975-09-29 1981-04-28 The Regents Of The University Of California 3-Deoxy-1α-hydroxy- and 3-deoxy-1α,25-dihydroxycholecalciferol and processes for the preparation thereof
US4038272A (en) * 1975-10-20 1977-07-26 Hoffmann-La Roche Inc. Stereospecific syntheses of 24r,25- and 24s,25-dihydroxycholesterol and alkanoyl derivatives thereof
US3994878A (en) * 1975-10-10 1976-11-30 Hoffmann-La Roche Inc. Syntheses of 24R,25- and 24S,25-dihydroxycholesterol and alkanoyl derivatives thereof
CH628907A5 (en) * 1975-10-10 1982-03-31 Hoffmann La Roche Process for the preparation of 24,25-dihydroxycholesterol derivatives
JPS5371056A (en) * 1976-12-08 1978-06-24 Chugai Pharmaceut Co Ltd Steroid derivs.
JPS53144563A (en) * 1977-05-19 1978-12-15 Chugai Pharmaceut Co Ltd Preparation of steroid derivatives
EP0055999B1 (en) * 1979-02-15 1984-10-03 Teijin Limited Vitamin d3
CH644873A5 (de) * 1980-02-12 1984-08-31 Hoffmann La Roche Verfahren zur herstellung von cholesterinderivaten.
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
PL3639828T3 (pl) 2013-12-24 2022-05-02 Virginia Commonwealth University Zastosowanie utlenowanych siarczanów cholesterolu (ocs) w leczeniu ostrej niewydolności wątroby
EP3494125B1 (en) 2016-08-02 2022-06-22 Virginia Commonwealth University Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
CN111320663B (zh) * 2018-12-13 2023-01-24 上海医药工业研究院 一种24-胆烯烯酸乙酯中间体的制备方法
EP3965773B1 (en) 2019-05-09 2025-12-31 Fermenta Biotech Limited NEW PROCESS FOR THE SYNTHESIS OF 25-OH CHOLESTEROL/CALCIFEDIOL FROM PHYTOSTEROL
US20220372065A1 (en) * 2019-07-09 2022-11-24 Fermenta Biotech Limited Synthesis of cholesterol and vitamin d3 from phytosterols
CN111138512A (zh) * 2019-12-27 2020-05-12 郑州手性药物研究院有限公司 一种合成25-羟基胆固醇中间体的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL150682B (nl) * 1968-07-01 1976-09-15 Wisconsin Alumni Res Found Werkwijze ter bereiding van een farmacologisch werkzaam preparaat, dat een vitamine d-derivaat bevat, alsmede gevormde voedingsmiddelen.
US3846455A (en) * 1972-05-22 1974-11-05 Eisai Co Ltd Process for the preparation of 25-hydroxy-cholesterol and esters thereof

Also Published As

Publication number Publication date
BE815252A (fr) 1974-11-20
FR2236854B1 (https=) 1977-10-21
JPS5018458A (https=) 1975-02-26
ATA416374A (de) 1977-09-15
AT343294B (de) 1978-05-26
NL172956C (nl) 1983-11-16
DE2424498B2 (de) 1980-06-04
GB1445237A (en) 1976-08-04
NL7406748A (https=) 1974-11-25
DE2424498C3 (de) 1981-04-02
US3822254A (en) 1974-07-02
JPS5614679B2 (https=) 1981-04-06
FR2236854A1 (https=) 1975-02-07
NL172956B (nl) 1983-06-16
DE2424498A1 (de) 1974-12-12
CH617442A5 (https=) 1980-05-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee