GB1441533A - Hydroxyquinolines and pharmaceutical preparations comprising such compounds - Google Patents

Hydroxyquinolines and pharmaceutical preparations comprising such compounds

Info

Publication number
GB1441533A
GB1441533A GB3787074A GB3787074A GB1441533A GB 1441533 A GB1441533 A GB 1441533A GB 3787074 A GB3787074 A GB 3787074A GB 3787074 A GB3787074 A GB 3787074A GB 1441533 A GB1441533 A GB 1441533A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydrogen
compound
formula
nitrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3787074A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
THIEMANN CHEM PHARM FAB
Original Assignee
THIEMANN CHEM PHARM FAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by THIEMANN CHEM PHARM FAB filed Critical THIEMANN CHEM PHARM FAB
Publication of GB1441533A publication Critical patent/GB1441533A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1441533 Hydroxyquinolines CHEM PHARMAZ FABRIK DR HERMANN THIEMANN GmbH 29 Aug 1974 [29 Aug 1973] 37870/74 Heading C2C [Also in Division A5] Novel compounds of the Formula I and salts thereof wherein R<SP>1</SP> is hydrogen or alkyl, R<SP>2</SP> is hydrogen, alkyl or aryl; R<SP>3</SP> and R<SP>4</SP>, which may be the same or different, each are alkyl or together with the nitrogen atom to which they are bonded form a pyrrolidino, piperidino, morpholino, piperazino or piperazino substituted at the nitrogen atom by alkyl or by #-hydroxyethyl; R<SP>5</SP> is hydrogen, halogen, hydroxy, methoxy, nitro, alkyl or unsubstituted, acylated or alkylated amino in which alkyl groups have 1 to 4 carbon atoms, with the pro viso that when R<SP>1</SP> is methyl and R<SP>2</SP> and R<SP>5</SP> each are hydrogen, R<SP>3</SP> and R<SP>4</SP> do not each represent ethyl or, together with the nitrogen atom to which they are bonded, form a piperidino ring may be prepared by reacting a compound of the Formula II with an aldehyde R<SP>2</SP>CHO and an amine or a salt thereof wherein R<SP>5</SP> is H, halogen, OH, OCH 3 NO 2 or alkyl and, optionally to form a compound I in which R<SP>5</SP> is an optionally alkylated or acylated amino group, reducing a compound of the Formula I in which R 5 is NO 2 and optionally alkylating or acylating the free amino group thus formed.
GB3787074A 1973-08-29 1974-08-29 Hydroxyquinolines and pharmaceutical preparations comprising such compounds Expired GB1441533A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732343549 DE2343549A1 (en) 1973-08-29 1973-08-29 4-HYDROXYCHINOLINE COMPOUNDS AND MEDICINAL PRODUCTS CONTAINING SUCH COMPOUNDS

Publications (1)

Publication Number Publication Date
GB1441533A true GB1441533A (en) 1976-07-07

Family

ID=5891033

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3787074A Expired GB1441533A (en) 1973-08-29 1974-08-29 Hydroxyquinolines and pharmaceutical preparations comprising such compounds

Country Status (5)

Country Link
BE (1) BE819363A (en)
DE (1) DE2343549A1 (en)
FR (1) FR2242100B1 (en)
GB (1) GB1441533A (en)
NL (1) NL7411347A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH625521A5 (en) * 1976-10-15 1981-09-30 Sandoz Ag

Also Published As

Publication number Publication date
FR2242100A1 (en) 1975-03-28
DE2343549A1 (en) 1975-03-13
FR2242100B1 (en) 1978-07-21
NL7411347A (en) 1975-03-04
BE819363A (en) 1974-12-16

Similar Documents

Publication Publication Date Title
ES422395A1 (en) Aromatic carboxylic amide derivatives
DE3061175D1 (en) Glucosamine-peptide derivatives, their production and use
ES408565A1 (en) Cyclic diamine derivatives
GB1390748A (en) Alkyl and cycloalkylthiophenylalkylaminoalkanols their salts and the preparation thereof
IE40511B1 (en) N-(1-(-phenylalkyl)-piperidyl-j)-(-(-pyridyl)-carbonic acid amides
GB1344976A (en) Aminoalkanol compounds and methods for their production
GB1416872A (en) 4-aminoquinoline derivatives
GB1433920A (en) Alkanolamine derivatives
GB1369248A (en) Amides the preparation thereof and their use in pharmacjeutical compositions
GB1462036A (en) Aminoindane derivatives
GB1441533A (en) Hydroxyquinolines and pharmaceutical preparations comprising such compounds
GB1342321A (en) Nitrofuran derivatives
SE314986B (en)
GB1462095A (en) Substituted triazolo-1,5-benzodiazepines
ES405479A1 (en) Benzodiazepin-2-ones
GB1338459A (en) Flavanone derivatives and process for inhibiting growth of microorganisms using such compounds
GB1514225A (en) Paracetamol derivatives
GB1345214A (en) Isoxazoles
GB1430551A (en) Piperazine derivatives
GB1423346A (en) Colour formers
GB1299566A (en) Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones
GB1339010A (en) Tetrazolyl-anthraquinone derivatives
GB1452413A (en)
GB1177240A (en) Formamidine Derivatives
ES422737A1 (en) Procedure for the obtaining of heterociclic compounds based on piperazine or homopiperazine. (Machine-translation by Google Translate, not legally binding)

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee