GB1439225A - Sedative peptides - Google Patents
Sedative peptidesInfo
- Publication number
- GB1439225A GB1439225A GB3213473A GB3213473A GB1439225A GB 1439225 A GB1439225 A GB 1439225A GB 3213473 A GB3213473 A GB 3213473A GB 3213473 A GB3213473 A GB 3213473A GB 1439225 A GB1439225 A GB 1439225A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phe
- group
- boc
- dam
- met
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 239000000932 sedative agent Substances 0.000 title abstract 2
- 230000001624 sedative effect Effects 0.000 title abstract 2
- FADYJNXDPBKVCA-UHFFFAOYSA-N L-Phenylalanyl-L-lysin Natural products NCCCCC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FADYJNXDPBKVCA-UHFFFAOYSA-N 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- -1 Boc Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108010018625 phenylalanylarginine Proteins 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
- C07K14/6955—Corticotropin [ACTH] with at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NLAANVRAGE7209839,A NL175618C (nl) | 1972-07-15 | 1972-07-15 | Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat bevat, alsmede een werkwijze ter bereiding van dergelijke peptiden. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1439225A true GB1439225A (en) | 1976-06-16 |
Family
ID=19816526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3213473A Expired GB1439225A (en) | 1972-07-15 | 1973-07-05 | Sedative peptides |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3853838A ( ) |
| JP (1) | JPS5936611B2 ( ) |
| AU (1) | AU471401B2 ( ) |
| BE (1) | BE802335A ( ) |
| CA (1) | CA1019723A ( ) |
| CH (1) | CH605674A5 ( ) |
| DE (1) | DE2335826C2 ( ) |
| FR (1) | FR2192838B1 ( ) |
| GB (1) | GB1439225A ( ) |
| HU (1) | HU169437B ( ) |
| NL (1) | NL175618C ( ) |
| SE (1) | SE392721B ( ) |
| ZA (1) | ZA734648B ( ) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7607683A (nl) * | 1976-07-12 | 1978-01-16 | Akzo Nv | Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan. |
| US4144228A (en) * | 1976-05-07 | 1979-03-13 | G. D. Searle & Co. | Methionine5 -enkephalin sulfoxides and sulfones |
| NL7607684A (nl) * | 1976-07-12 | 1978-01-16 | Akzo Nv | Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan. |
| US4356119A (en) * | 1978-09-28 | 1982-10-26 | Nordisk Insulinlaboratorium | Therapeutically active polypeptides or acid addition salts and a process for producing such compounds |
| US4623715A (en) * | 1984-10-22 | 1986-11-18 | Hoechst Aktiengeselleschaft | Novel peptides which are active on the central nervous system and have an action on the cholinergic system |
| NZ214543A (en) * | 1984-12-14 | 1990-03-27 | Australian Commercial Research | Amino acid and peptide derivatives that inhibit human leucocytic elastase enzyme (hle) |
| US7632803B2 (en) | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| US7592304B2 (en) | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| US20130059914A1 (en) * | 2010-04-21 | 2013-03-07 | Signature Therapeutics, Inc. | Compositions Comprising Enzyme-Cleavable Amphetamine Prodrugs and Inhibitors Thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL278010A ( ) * | 1961-05-04 | 1900-01-01 | ||
| NL6509727A ( ) * | 1965-07-28 | 1967-01-30 | ||
| GB1230472A ( ) * | 1967-07-10 | 1971-05-05 |
-
1972
- 1972-07-15 NL NLAANVRAGE7209839,A patent/NL175618C/xx not_active IP Right Cessation
-
1973
- 1973-07-05 GB GB3213473A patent/GB1439225A/en not_active Expired
- 1973-07-10 US US00377978A patent/US3853838A/en not_active Expired - Lifetime
- 1973-07-10 ZA ZA734648A patent/ZA734648B/xx unknown
- 1973-07-11 AU AU57983/73A patent/AU471401B2/en not_active Expired
- 1973-07-11 CA CA176,197A patent/CA1019723A/en not_active Expired
- 1973-07-13 FR FR7325905A patent/FR2192838B1/fr not_active Expired
- 1973-07-13 SE SE7309861A patent/SE392721B/xx unknown
- 1973-07-13 DE DE2335826A patent/DE2335826C2/de not_active Expired
- 1973-07-13 HU HUAO372A patent/HU169437B/hu unknown
- 1973-07-13 JP JP48079221A patent/JPS5936611B2/ja not_active Expired
- 1973-07-13 BE BE133475A patent/BE802335A/xx not_active IP Right Cessation
- 1973-07-13 CH CH1025473A patent/CH605674A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU471401B2 (en) | 1976-04-29 |
| FR2192838A1 ( ) | 1974-02-15 |
| SE392721B (sv) | 1977-04-18 |
| JPS5936611B2 (ja) | 1984-09-05 |
| NL175618B (nl) | 1984-07-02 |
| BE802335A (fr) | 1974-01-14 |
| CA1019723A (en) | 1977-10-25 |
| US3853838A (en) | 1974-12-10 |
| AU5798373A (en) | 1975-01-16 |
| NL7209839A ( ) | 1974-01-17 |
| JPS4951278A ( ) | 1974-05-18 |
| CH605674A5 ( ) | 1978-10-13 |
| DE2335826A1 (de) | 1974-01-31 |
| ZA734648B (en) | 1974-06-26 |
| DE2335826C2 (de) | 1984-01-05 |
| HU169437B ( ) | 1976-11-28 |
| FR2192838B1 ( ) | 1977-01-28 |
| NL175618C (nl) | 1984-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |