GB1437868A - Arylpiperazinoalkyl esters - Google Patents
Arylpiperazinoalkyl estersInfo
- Publication number
- GB1437868A GB1437868A GB1987374A GB1987374A GB1437868A GB 1437868 A GB1437868 A GB 1437868A GB 1987374 A GB1987374 A GB 1987374A GB 1987374 A GB1987374 A GB 1987374A GB 1437868 A GB1437868 A GB 1437868A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- formula
- compound
- acid
- trifluoromethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002148 esters Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 7
- 239000002253 acid Substances 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- HYPXXPJLGDQJDV-UHFFFAOYSA-N 2-[4-(3-chlorophenyl)piperazin-1-yl]ethanol Chemical compound C1CN(CCO)CCN1C1=CC=CC(Cl)=C1 HYPXXPJLGDQJDV-UHFFFAOYSA-N 0.000 abstract 1
- YISRXFBKCWEVAQ-UHFFFAOYSA-N 2-[4-(3-chlorophenyl)piperazin-1-yl]ethyl 2-nitrobenzoate Chemical compound [O-][N+](=O)C1=CC=CC=C1C(=O)OCCN1CCN(C=2C=C(Cl)C=CC=2)CC1 YISRXFBKCWEVAQ-UHFFFAOYSA-N 0.000 abstract 1
- BWWHTIHDQBHTHP-UHFFFAOYSA-N 2-nitrobenzoyl chloride Chemical compound [O-][N+](=O)C1=CC=CC=C1C(Cl)=O BWWHTIHDQBHTHP-UHFFFAOYSA-N 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 hydroxy, acetoxy, amino Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7316634A FR2228779A1 (en) | 1973-05-09 | 1973-05-09 | (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use |
| FR7402793A FR2258840A1 (en) | 1974-01-29 | 1974-01-29 | (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1437868A true GB1437868A (en) | 1976-06-03 |
Family
ID=26217710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1987374A Expired GB1437868A (en) | 1973-05-09 | 1974-05-06 | Arylpiperazinoalkyl esters |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US3953449A (en, 2012) |
| ES (1) | ES426135A1 (en, 2012) |
| GB (1) | GB1437868A (en, 2012) |
| NL (1) | NL7406258A (en, 2012) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0141884A1 (en) * | 1983-11-09 | 1985-05-22 | Juste, S.A. Quimico-Farmaceutica | Novel phenylpiperazine derivatives, process for preparing them and therapeutic compositions containing them |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU174215B (hu) * | 1976-12-15 | 1979-11-28 | Richter Gedeon Vegyeszet | Sposob poluchenija novykh proizvodnykh piperazina i kislotnykh additivnykh i chetvjortichnykh solej |
| DE2658938A1 (de) * | 1976-12-24 | 1978-07-06 | Hoechst Ag | Neue basisch substituierte 0-propyloxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB1560271A (en) * | 1977-01-14 | 1980-02-06 | Joullie International Sa | Therapeutically useful m-trifluoromethylphenylpiperazine derivatives |
| US4202898A (en) * | 1978-06-05 | 1980-05-13 | Synthelabo | Method of treating anxiety and depression |
| GR65999B (en, 2012) * | 1978-07-24 | 1981-01-13 | Hexachimie | |
| IT1190133B (it) * | 1986-06-19 | 1988-02-10 | Chiesi Farma Spa | Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB889223A (en) | 1958-08-01 | 1962-02-14 | Miles Lab | Phenylpiperazinylalkyl esters and amides |
| US3557107A (en) * | 1967-05-01 | 1971-01-19 | Shulton Inc | Phenylpiperazinylalkyl alkoxy anthranilates |
| US3846430A (en) * | 1968-01-12 | 1974-11-05 | Bruneau & Cie Lab | 1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine |
-
1974
- 1974-05-06 GB GB1987374A patent/GB1437868A/en not_active Expired
- 1974-05-06 US US05/467,595 patent/US3953449A/en not_active Expired - Lifetime
- 1974-05-09 ES ES426135A patent/ES426135A1/es not_active Expired
- 1974-05-09 NL NL7406258A patent/NL7406258A/xx not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0141884A1 (en) * | 1983-11-09 | 1985-05-22 | Juste, S.A. Quimico-Farmaceutica | Novel phenylpiperazine derivatives, process for preparing them and therapeutic compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| US3953449A (en) | 1976-04-27 |
| DE2421537B2 (de) | 1976-05-20 |
| NL7406258A (en, 2012) | 1974-11-12 |
| ES426135A1 (es) | 1976-11-01 |
| DE2421537A1 (de) | 1974-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |