GB1434919A - 3alpha-hydroxy androstanes - Google Patents
3alpha-hydroxy androstanesInfo
- Publication number
- GB1434919A GB1434919A GB2811872A GB2811872A GB1434919A GB 1434919 A GB1434919 A GB 1434919A GB 2811872 A GB2811872 A GB 2811872A GB 2811872 A GB2811872 A GB 2811872A GB 1434919 A GB1434919 A GB 1434919A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- cyano
- steroids
- androstan
- positions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 abstract 4
- 150000000315 19-norandrostanes Chemical class 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical compound C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001805 chlorine compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 di-substituted carbamoyl group Chemical group 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2811872A GB1434919A (en) | 1972-06-15 | 1972-06-15 | 3alpha-hydroxy androstanes |
| BE132254A BE800899R (fr) | 1972-06-15 | 1973-06-14 | Composes de la serie de l'androstane a activite anesthesique et leur preparation |
| DE2330342A DE2330342A1 (de) | 1972-06-15 | 1973-06-14 | Steroidverbindungen |
| AU56937/73A AU477852B2 (en) | 1972-06-15 | 1973-06-14 | 3-hydroxy androstanes |
| CA174,050A CA1040619A (en) | 1972-06-15 | 1973-06-14 | Steroids of the androstane series, having anaesthetic activity |
| DK328673AA DK136157B (da) | 1972-06-15 | 1973-06-14 | Analogifremgangsmåde til fremstilling af 3alfa-hydroxy-17beta-karboxylsyrederivater af androstanrækken eller salte deraf. |
| LU67790A LU67790A1 (enExample) | 1972-06-15 | 1973-06-14 | |
| NL7308267A NL7308267A (enExample) | 1972-06-15 | 1973-06-14 | |
| ZA734037A ZA734037B (en) | 1972-06-15 | 1973-06-14 | Compounds of the androstane series having anaesthetic activity |
| FR7321743A FR2189034B2 (enExample) | 1972-06-15 | 1973-06-14 | |
| US05/481,227 US3943124A (en) | 1970-12-17 | 1974-06-20 | Chemical compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2811872A GB1434919A (en) | 1972-06-15 | 1972-06-15 | 3alpha-hydroxy androstanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1434919A true GB1434919A (en) | 1976-05-12 |
Family
ID=10270562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2811872A Expired GB1434919A (en) | 1970-12-17 | 1972-06-15 | 3alpha-hydroxy androstanes |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE800899R (enExample) |
| CA (1) | CA1040619A (enExample) |
| DE (1) | DE2330342A1 (enExample) |
| DK (1) | DK136157B (enExample) |
| FR (1) | FR2189034B2 (enExample) |
| GB (1) | GB1434919A (enExample) |
| LU (1) | LU67790A1 (enExample) |
| NL (1) | NL7308267A (enExample) |
| ZA (1) | ZA734037B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| WO2014169831A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof |
| KR102614507B1 (ko) | 2013-04-17 | 2023-12-19 | 세이지 테라퓨틱스, 인크. | 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법 |
| PL2986624T3 (pl) | 2013-04-17 | 2020-11-16 | Sage Therapeutics, Inc. | Neuroaktywne steroidy 19-NOR do stosowania w sposobach leczenia |
| CA3199003A1 (en) * | 2013-07-19 | 2015-01-22 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| HUE052308T2 (hu) | 2013-08-23 | 2021-04-28 | Sage Therapeutics Inc | Neuroaktív szteroidok, készítmények és alkalmazásuk |
| US10246482B2 (en) | 2014-06-18 | 2019-04-02 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| CN117024502A (zh) | 2014-10-16 | 2023-11-10 | 萨奇治疗股份有限公司 | 靶向cns障碍的组合物和方法 |
| EP3206493B1 (en) | 2014-10-16 | 2020-05-06 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| EP3719029A1 (en) | 2014-11-27 | 2020-10-07 | Sage Therapeutics, Inc. | Compositions for inducing sedation |
| ES2857082T3 (es) | 2015-01-26 | 2021-09-28 | Sage Therapeutics Inc | Composiciones y métodos para el tratamiento de trastornos del SNC |
| JP6875996B2 (ja) | 2015-02-20 | 2021-05-26 | セージ セラピューティクス， インコーポレイテッド | 神経刺激性ステロイド、組成物、およびその使用 |
| MA45599A (fr) | 2016-07-11 | 2019-05-15 | Sage Therapeutics Inc | Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation |
| AU2017296295B2 (en) | 2016-07-11 | 2022-02-24 | Sage Therapeutics, Inc. | C7, C12, and C16 substituted neuroactive steroids and their methods of use |
| WO2020243488A1 (en) | 2019-05-31 | 2020-12-03 | Sage Therapeutics, Inc. | Neuroactive steroids and compositions thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH273860A (de) * | 1942-04-25 | 1951-02-28 | Nv Organon | Verfahren zur Herstellung einer im Ring C eine sauerstoffhaltige Gruppe enthaltenden Verbindung der Cyclopentanopolyhydrophenanthren-Reihe. |
| GB1380246A (en) * | 1970-12-17 | 1975-01-08 | Glaxo Lab Ltd | 3alpha-hydroxy-androstanes and esters thereof |
| CA988508A (en) * | 1970-12-17 | 1976-05-04 | Christopher E. Newall | Steroids having useful anaesthetic activity and processes for their preparation |
-
1972
- 1972-06-15 GB GB2811872A patent/GB1434919A/en not_active Expired
-
1973
- 1973-06-14 DK DK328673AA patent/DK136157B/da unknown
- 1973-06-14 NL NL7308267A patent/NL7308267A/xx not_active Application Discontinuation
- 1973-06-14 CA CA174,050A patent/CA1040619A/en not_active Expired
- 1973-06-14 DE DE2330342A patent/DE2330342A1/de not_active Ceased
- 1973-06-14 FR FR7321743A patent/FR2189034B2/fr not_active Expired
- 1973-06-14 ZA ZA734037A patent/ZA734037B/xx unknown
- 1973-06-14 LU LU67790A patent/LU67790A1/xx unknown
- 1973-06-14 BE BE132254A patent/BE800899R/xx active
Also Published As
| Publication number | Publication date |
|---|---|
| BE800899R (fr) | 1973-12-14 |
| DK136157C (enExample) | 1978-01-23 |
| AU5693773A (en) | 1974-12-19 |
| NL7308267A (enExample) | 1973-12-18 |
| DK136157B (da) | 1977-08-22 |
| CA1040619A (en) | 1978-10-17 |
| LU67790A1 (enExample) | 1973-08-16 |
| ZA734037B (en) | 1974-05-29 |
| FR2189034B2 (enExample) | 1977-01-21 |
| DE2330342A1 (de) | 1974-01-17 |
| FR2189034A2 (enExample) | 1974-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |