GB1432731A - Pyrimidopyrimidines - Google Patents
PyrimidopyrimidinesInfo
- Publication number
- GB1432731A GB1432731A GB58674A GB58674A GB1432731A GB 1432731 A GB1432731 A GB 1432731A GB 58674 A GB58674 A GB 58674A GB 58674 A GB58674 A GB 58674A GB 1432731 A GB1432731 A GB 1432731A
- Authority
- GB
- United Kingdom
- Prior art keywords
- replaceable
- alkyl
- formula
- hydroxyalkyl
- jan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1432731 Pyrimidopyrimidines DR KARL THOMAE GmbH 7 Jan 1974 [8 Jan 1973] 00586/74 Heading C2C Compounds of the general formula (R 1 = C 1 -C 3 alkoxy-(C 2 -C 3 alkyl); R 2 = C 2 -C 4 hydroxyalkyl or C 3 dihydroxyalkyl; R 3 = C 1 -C 3 alkoxy-(C 2 -C 3 alkyl) or C 2 -C 3 hydroxyalkyl; R 4 = di(C 2 -C 4 alkyl)amino, diallylamino, piperidino or hexamethyleneimino) and their acid addition salts are prepared by (a) reacting a compound of the formula (one Z 1 = replaceable atom or group and the other = NR 1 R 2 or NR 2 R 3 , or both symbols Z 1 = replaceable atoms or groups) with R 1 R 2 NH or R 2 R 3 NH or (b) reacting a compound of the formula (one Z 2 = replaceable group and the other = R 4 , or both symbols Z 2 = replaceable groups) with R 4 H, optionally followed in either case by salt formation. The above compounds increase blood pressure, affect blood oxygen transport, inhibit thrombocyte aggregation, enhance blood flow and are coronary dilators. They may be administered in the form of pharmaceutical preparations containing them in association witha carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2300661A DE2300661C3 (en) | 1973-01-08 | 1973-01-08 | Pyrimido [5,4-d] pyrimidines, their physiologically acceptable acid addition salts, processes for their preparation and medicaments containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1432731A true GB1432731A (en) | 1976-04-22 |
Family
ID=5868472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB58674A Expired GB1432731A (en) | 1973-01-08 | 1974-01-07 | Pyrimidopyrimidines |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS4995996A (en) |
| KR (1) | KR780000136B1 (en) |
| AT (1) | AT334378B (en) |
| BE (1) | BE809474A (en) |
| BG (1) | BG25987A3 (en) |
| CH (1) | CH590285A5 (en) |
| DD (1) | DD110496A5 (en) |
| DE (1) | DE2300661C3 (en) |
| DK (1) | DK133300C (en) |
| ES (1) | ES421810A1 (en) |
| FR (1) | FR2213066B1 (en) |
| GB (1) | GB1432731A (en) |
| HU (1) | HU166653B (en) |
| IE (1) | IE38725B1 (en) |
| IL (1) | IL43967A (en) |
| NL (1) | NL7400100A (en) |
| PH (1) | PH9640A (en) |
| PL (1) | PL91246B1 (en) |
| RO (1) | RO63660A (en) |
| SU (1) | SU509227A3 (en) |
| ZA (1) | ZA7493B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4388318A (en) * | 1981-09-29 | 1983-06-14 | Boehringer Ingelheim International Gmbh | Method of treating endotoxin shock with a pyrimido-pyrimidine derivative |
| US4963541A (en) * | 1989-02-22 | 1990-10-16 | Abbott Laboratories | Pyrimido-pyrimidine lipoxygenase inhibiting compounds |
-
1973
- 1973-01-08 DE DE2300661A patent/DE2300661C3/en not_active Expired
- 1973-12-10 AT AT1028473A patent/AT334378B/en active
- 1973-12-17 BG BG025269A patent/BG25987A3/en unknown
- 1973-12-27 ES ES421810A patent/ES421810A1/en not_active Expired
- 1973-12-27 JP JP49004765A patent/JPS4995996A/ja active Pending
- 1973-12-27 SU SU1980992A patent/SU509227A3/en active
- 1973-12-31 KR KR7302360A patent/KR780000136B1/en active
-
1974
- 1974-01-04 CH CH8274A patent/CH590285A5/xx not_active IP Right Cessation
- 1974-01-04 DD DD175839A patent/DD110496A5/xx unknown
- 1974-01-04 NL NL7400100A patent/NL7400100A/xx not_active Application Discontinuation
- 1974-01-05 RO RO197477199A patent/RO63660A/en unknown
- 1974-01-07 GB GB58674A patent/GB1432731A/en not_active Expired
- 1974-01-07 ZA ZA00740093A patent/ZA7493B/en unknown
- 1974-01-07 IL IL43967A patent/IL43967A/en unknown
- 1974-01-07 PL PL1974167952A patent/PL91246B1/pl unknown
- 1974-01-07 DK DK7474*#A patent/DK133300C/en active
- 1974-01-07 BE BE139590A patent/BE809474A/en unknown
- 1974-01-07 HU HUTO950A patent/HU166653B/hu unknown
- 1974-01-08 FR FR7400569A patent/FR2213066B1/fr not_active Expired
- 1974-01-08 PH PH15387*UA patent/PH9640A/en unknown
- 1974-01-08 IE IE41/74A patent/IE38725B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU166653B (en) | 1975-04-28 |
| PL91246B1 (en) | 1977-02-28 |
| PH9640A (en) | 1976-01-26 |
| IE38725L (en) | 1974-07-08 |
| JPS4995996A (en) | 1974-09-11 |
| NL7400100A (en) | 1974-07-10 |
| DK133300C (en) | 1976-09-27 |
| FR2213066A1 (en) | 1974-08-02 |
| IL43967A (en) | 1977-05-31 |
| DE2300661A1 (en) | 1974-07-18 |
| IE38725B1 (en) | 1978-05-24 |
| DD110496A5 (en) | 1974-12-20 |
| SU509227A3 (en) | 1976-03-30 |
| ES421810A1 (en) | 1976-04-16 |
| DE2300661C3 (en) | 1979-10-31 |
| DK133300B (en) | 1976-04-26 |
| RO63660A (en) | 1978-12-15 |
| FR2213066B1 (en) | 1977-09-02 |
| IL43967A0 (en) | 1974-05-16 |
| DE2300661B2 (en) | 1979-03-08 |
| KR780000136B1 (en) | 1978-04-25 |
| ZA7493B (en) | 1975-09-24 |
| BG25987A3 (en) | 1979-01-12 |
| ATA1028473A (en) | 1976-05-15 |
| AT334378B (en) | 1976-01-10 |
| BE809474A (en) | 1974-07-08 |
| CH590285A5 (en) | 1977-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1409693A (en) | Triazolobenzodiazepines | |
| GB1147379A (en) | 4-alkyl-dialkoxy-ª‡-methylphenethylamines and pharmacologically acceptable salts | |
| GB1409768A (en) | Hererocyclic derivatives of a guanidine | |
| GB1456627A (en) | Pyridobenzodiazepinones | |
| GB1399230A (en) | Pyrazolodiazepine compounds and methods for their production | |
| GB1462036A (en) | Aminoindane derivatives | |
| GB1432731A (en) | Pyrimidopyrimidines | |
| GB1475314A (en) | Phenyl-propylamine derivatives | |
| GB1343527A (en) | Amino-propanol derivatives | |
| GB1295489A (en) | ||
| GB1237352A (en) | Substituted propylamines | |
| SE7412147L (en) | ||
| GB1345214A (en) | Isoxazoles | |
| GB1290381A (en) | ||
| GB1338459A (en) | Flavanone derivatives and process for inhibiting growth of microorganisms using such compounds | |
| GB1451389A (en) | Indolobenzazepines | |
| GB1280288A (en) | Pyrimidopyrimidines | |
| GB1431259A (en) | 1-substituted-6-phenyl-4h-s-triazolo- 4,3-a- 1,4- benzodiazepines | |
| GB1275875A (en) | 3-amino-2-(3,4-disubstituted)bicyclo(2.2.2)octan-2-ols | |
| GB1169990A (en) | Phenoxy Propan-2-Olamines | |
| GB1225677A (en) | ||
| GB1299566A (en) | Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones | |
| GB1339010A (en) | Tetrazolyl-anthraquinone derivatives | |
| GB1414589A (en) | Yohimbohydrazide derivatives process for their preparation and their applications | |
| GB1371757A (en) | Substituted aminoquinolizinium bromides their preparation and compositions thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |