GB1432731A - Pyrimidopyrimidines - Google Patents

Pyrimidopyrimidines

Info

Publication number
GB1432731A
GB1432731A GB58674A GB58674A GB1432731A GB 1432731 A GB1432731 A GB 1432731A GB 58674 A GB58674 A GB 58674A GB 58674 A GB58674 A GB 58674A GB 1432731 A GB1432731 A GB 1432731A
Authority
GB
United Kingdom
Prior art keywords
replaceable
alkyl
formula
hydroxyalkyl
jan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB58674A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB1432731A publication Critical patent/GB1432731A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1432731 Pyrimidopyrimidines DR KARL THOMAE GmbH 7 Jan 1974 [8 Jan 1973] 00586/74 Heading C2C Compounds of the general formula (R 1 = C 1 -C 3 alkoxy-(C 2 -C 3 alkyl); R 2 = C 2 -C 4 hydroxyalkyl or C 3 dihydroxyalkyl; R 3 = C 1 -C 3 alkoxy-(C 2 -C 3 alkyl) or C 2 -C 3 hydroxyalkyl; R 4 = di(C 2 -C 4 alkyl)amino, diallylamino, piperidino or hexamethyleneimino) and their acid addition salts are prepared by (a) reacting a compound of the formula (one Z 1 = replaceable atom or group and the other = NR 1 R 2 or NR 2 R 3 , or both symbols Z 1 = replaceable atoms or groups) with R 1 R 2 NH or R 2 R 3 NH or (b) reacting a compound of the formula (one Z 2 = replaceable group and the other = R 4 , or both symbols Z 2 = replaceable groups) with R 4 H, optionally followed in either case by salt formation. The above compounds increase blood pressure, affect blood oxygen transport, inhibit thrombocyte aggregation, enhance blood flow and are coronary dilators. They may be administered in the form of pharmaceutical preparations containing them in association witha carrier.
GB58674A 1973-01-08 1974-01-07 Pyrimidopyrimidines Expired GB1432731A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2300661A DE2300661C3 (en) 1973-01-08 1973-01-08 Pyrimido [5,4-d] pyrimidines, their physiologically acceptable acid addition salts, processes for their preparation and medicaments containing them

Publications (1)

Publication Number Publication Date
GB1432731A true GB1432731A (en) 1976-04-22

Family

ID=5868472

Family Applications (1)

Application Number Title Priority Date Filing Date
GB58674A Expired GB1432731A (en) 1973-01-08 1974-01-07 Pyrimidopyrimidines

Country Status (21)

Country Link
JP (1) JPS4995996A (en)
KR (1) KR780000136B1 (en)
AT (1) AT334378B (en)
BE (1) BE809474A (en)
BG (1) BG25987A3 (en)
CH (1) CH590285A5 (en)
DD (1) DD110496A5 (en)
DE (1) DE2300661C3 (en)
DK (1) DK133300C (en)
ES (1) ES421810A1 (en)
FR (1) FR2213066B1 (en)
GB (1) GB1432731A (en)
HU (1) HU166653B (en)
IE (1) IE38725B1 (en)
IL (1) IL43967A (en)
NL (1) NL7400100A (en)
PH (1) PH9640A (en)
PL (1) PL91246B1 (en)
RO (1) RO63660A (en)
SU (1) SU509227A3 (en)
ZA (1) ZA7493B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388318A (en) * 1981-09-29 1983-06-14 Boehringer Ingelheim International Gmbh Method of treating endotoxin shock with a pyrimido-pyrimidine derivative
US4963541A (en) * 1989-02-22 1990-10-16 Abbott Laboratories Pyrimido-pyrimidine lipoxygenase inhibiting compounds

Also Published As

Publication number Publication date
HU166653B (en) 1975-04-28
PL91246B1 (en) 1977-02-28
PH9640A (en) 1976-01-26
IE38725L (en) 1974-07-08
JPS4995996A (en) 1974-09-11
NL7400100A (en) 1974-07-10
DK133300C (en) 1976-09-27
FR2213066A1 (en) 1974-08-02
IL43967A (en) 1977-05-31
DE2300661A1 (en) 1974-07-18
IE38725B1 (en) 1978-05-24
DD110496A5 (en) 1974-12-20
SU509227A3 (en) 1976-03-30
ES421810A1 (en) 1976-04-16
DE2300661C3 (en) 1979-10-31
DK133300B (en) 1976-04-26
RO63660A (en) 1978-12-15
FR2213066B1 (en) 1977-09-02
IL43967A0 (en) 1974-05-16
DE2300661B2 (en) 1979-03-08
KR780000136B1 (en) 1978-04-25
ZA7493B (en) 1975-09-24
BG25987A3 (en) 1979-01-12
ATA1028473A (en) 1976-05-15
AT334378B (en) 1976-01-10
BE809474A (en) 1974-07-08
CH590285A5 (en) 1977-07-29

Similar Documents

Publication Publication Date Title
GB1409693A (en) Triazolobenzodiazepines
GB1147379A (en) 4-alkyl-dialkoxy-ª‡-methylphenethylamines and pharmacologically acceptable salts
GB1409768A (en) Hererocyclic derivatives of a guanidine
GB1456627A (en) Pyridobenzodiazepinones
GB1399230A (en) Pyrazolodiazepine compounds and methods for their production
GB1462036A (en) Aminoindane derivatives
GB1432731A (en) Pyrimidopyrimidines
GB1475314A (en) Phenyl-propylamine derivatives
GB1343527A (en) Amino-propanol derivatives
GB1295489A (en)
GB1237352A (en) Substituted propylamines
SE7412147L (en)
GB1345214A (en) Isoxazoles
GB1290381A (en)
GB1338459A (en) Flavanone derivatives and process for inhibiting growth of microorganisms using such compounds
GB1451389A (en) Indolobenzazepines
GB1280288A (en) Pyrimidopyrimidines
GB1431259A (en) 1-substituted-6-phenyl-4h-s-triazolo- 4,3-a- 1,4- benzodiazepines
GB1275875A (en) 3-amino-2-(3,4-disubstituted)bicyclo(2.2.2)octan-2-ols
GB1169990A (en) Phenoxy Propan-2-Olamines
GB1225677A (en)
GB1299566A (en) Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones
GB1339010A (en) Tetrazolyl-anthraquinone derivatives
GB1414589A (en) Yohimbohydrazide derivatives process for their preparation and their applications
GB1371757A (en) Substituted aminoquinolizinium bromides their preparation and compositions thereof

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee