IE38725L - Pyrimidopyrimidine derivatives - Google Patents
Pyrimidopyrimidine derivativesInfo
- Publication number
- IE38725L IE38725L IE740041A IE4174A IE38725L IE 38725 L IE38725 L IE 38725L IE 740041 A IE740041 A IE 740041A IE 4174 A IE4174 A IE 4174A IE 38725 L IE38725 L IE 38725L
- Authority
- IE
- Ireland
- Prior art keywords
- replaceable
- alkyl
- formula
- hydroxyalkyl
- jan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1432731 Pyrimidopyrimidines DR KARL THOMAE GmbH 7 Jan 1974 [8 Jan 1973] 00586/74 Heading C2C Compounds of the general formula (R 1 = C 1 -C 3 alkoxy-(C 2 -C 3 alkyl); R 2 = C 2 -C 4 hydroxyalkyl or C 3 dihydroxyalkyl; R 3 = C 1 -C 3 alkoxy-(C 2 -C 3 alkyl) or C 2 -C 3 hydroxyalkyl; R 4 = di(C 2 -C 4 alkyl)amino, diallylamino, piperidino or hexamethyleneimino) and their acid addition salts are prepared by (a) reacting a compound of the formula (one Z 1 = replaceable atom or group and the other = NR 1 R 2 or NR 2 R 3 , or both symbols Z 1 = replaceable atoms or groups) with R 1 R 2 NH or R 2 R 3 NH or (b) reacting a compound of the formula (one Z 2 = replaceable group and the other = R 4 , or both symbols Z 2 = replaceable groups) with R 4 H, optionally followed in either case by salt formation. The above compounds increase blood pressure, affect blood oxygen transport, inhibit thrombocyte aggregation, enhance blood flow and are coronary dilators. They may be administered in the form of pharmaceutical preparations containing them in association witha carrier.
[GB1432731A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2300661A DE2300661C3 (en) | 1973-01-08 | 1973-01-08 | Pyrimido [5,4-d] pyrimidines, their physiologically acceptable acid addition salts, processes for their preparation and medicaments containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38725L true IE38725L (en) | 1974-07-08 |
| IE38725B1 IE38725B1 (en) | 1978-05-24 |
Family
ID=5868472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE41/74A IE38725B1 (en) | 1973-01-08 | 1974-01-08 | Pyrimidopyrimidines |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS4995996A (en) |
| KR (1) | KR780000136B1 (en) |
| AT (1) | AT334378B (en) |
| BE (1) | BE809474A (en) |
| BG (1) | BG25987A3 (en) |
| CH (1) | CH590285A5 (en) |
| DD (1) | DD110496A5 (en) |
| DE (1) | DE2300661C3 (en) |
| DK (1) | DK133300C (en) |
| ES (1) | ES421810A1 (en) |
| FR (1) | FR2213066B1 (en) |
| GB (1) | GB1432731A (en) |
| HU (1) | HU166653B (en) |
| IE (1) | IE38725B1 (en) |
| IL (1) | IL43967A (en) |
| NL (1) | NL7400100A (en) |
| PH (1) | PH9640A (en) |
| PL (1) | PL91246B1 (en) |
| RO (1) | RO63660A (en) |
| SU (1) | SU509227A3 (en) |
| ZA (1) | ZA7493B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4388318A (en) * | 1981-09-29 | 1983-06-14 | Boehringer Ingelheim International Gmbh | Method of treating endotoxin shock with a pyrimido-pyrimidine derivative |
| US4963541A (en) * | 1989-02-22 | 1990-10-16 | Abbott Laboratories | Pyrimido-pyrimidine lipoxygenase inhibiting compounds |
-
1973
- 1973-01-08 DE DE2300661A patent/DE2300661C3/en not_active Expired
- 1973-12-10 AT AT1028473A patent/AT334378B/en active
- 1973-12-17 BG BG7325269A patent/BG25987A3/xx unknown
- 1973-12-27 SU SU1980992A patent/SU509227A3/en active
- 1973-12-27 JP JP49004765A patent/JPS4995996A/ja active Pending
- 1973-12-27 ES ES421810A patent/ES421810A1/en not_active Expired
- 1973-12-31 KR KR7302360A patent/KR780000136B1/en active
-
1974
- 1974-01-04 DD DD175839A patent/DD110496A5/xx unknown
- 1974-01-04 CH CH8274A patent/CH590285A5/xx not_active IP Right Cessation
- 1974-01-04 NL NL7400100A patent/NL7400100A/xx not_active Application Discontinuation
- 1974-01-05 RO RO197477199A patent/RO63660A/en unknown
- 1974-01-07 BE BE139590A patent/BE809474A/en unknown
- 1974-01-07 HU HUTO950A patent/HU166653B/hu unknown
- 1974-01-07 IL IL43967A patent/IL43967A/en unknown
- 1974-01-07 DK DK7474*#A patent/DK133300C/en active
- 1974-01-07 PL PL1974167952A patent/PL91246B1/pl unknown
- 1974-01-07 ZA ZA00740093A patent/ZA7493B/en unknown
- 1974-01-07 GB GB58674A patent/GB1432731A/en not_active Expired
- 1974-01-08 IE IE41/74A patent/IE38725B1/en unknown
- 1974-01-08 FR FR7400569A patent/FR2213066B1/fr not_active Expired
- 1974-01-08 PH PH15387*UA patent/PH9640A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH9640A (en) | 1976-01-26 |
| DE2300661A1 (en) | 1974-07-18 |
| IE38725B1 (en) | 1978-05-24 |
| IL43967A0 (en) | 1974-05-16 |
| DE2300661B2 (en) | 1979-03-08 |
| DK133300C (en) | 1976-09-27 |
| GB1432731A (en) | 1976-04-22 |
| AT334378B (en) | 1976-01-10 |
| DD110496A5 (en) | 1974-12-20 |
| ES421810A1 (en) | 1976-04-16 |
| NL7400100A (en) | 1974-07-10 |
| BG25987A3 (en) | 1979-01-12 |
| FR2213066B1 (en) | 1977-09-02 |
| DK133300B (en) | 1976-04-26 |
| HU166653B (en) | 1975-04-28 |
| BE809474A (en) | 1974-07-08 |
| SU509227A3 (en) | 1976-03-30 |
| ZA7493B (en) | 1975-09-24 |
| CH590285A5 (en) | 1977-07-29 |
| PL91246B1 (en) | 1977-02-28 |
| KR780000136B1 (en) | 1978-04-25 |
| FR2213066A1 (en) | 1974-08-02 |
| JPS4995996A (en) | 1974-09-11 |
| RO63660A (en) | 1978-12-15 |
| ATA1028473A (en) | 1976-05-15 |
| IL43967A (en) | 1977-05-31 |
| DE2300661C3 (en) | 1979-10-31 |
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