GB1428317A - Method for in vitro determination of thyroid function and diagnostic reagent composition therefor - Google Patents
Method for in vitro determination of thyroid function and diagnostic reagent composition thereforInfo
- Publication number
- GB1428317A GB1428317A GB1871774A GB1871774A GB1428317A GB 1428317 A GB1428317 A GB 1428317A GB 1871774 A GB1871774 A GB 1871774A GB 1871774 A GB1871774 A GB 1871774A GB 1428317 A GB1428317 A GB 1428317A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reagent composition
- silicon dioxide
- compositions
- diagnostic reagent
- iodothyronine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
1428317 Radio-active compositions MALLINCKRODT CHEMICAL WORKS 29 April 1974 [14 May 1973] 18717/74 Heading G6R [Also in Division G1] A diagnostic reagent composition for use in in vitro determination of thyroid function comprises a buffered aqueous suspension containing finely divided, amorphous silicon dioxide, thyroid hormone substance tagged with radioactive iodine and a non-ionic surfactant. In carrying out the determination, a blood serum sample is mixed with a measured amount of the reagent composition, the silicon dioxide is separated from the suspension and the radioactivity of the separated silicon dioxide or of the supernatant liquid is measured. Examples relate to compositions comprising a buffered aqueous suspension of microfine precipitated silica containing L-tri-iodothyronine (T-3) labelled with I-131 and as surfactant nonylphenoxypoly(ethyleneoxy) ethanol, polyoxyethylene (20) oleyl ether, polyoxyethylene (20) sorbitan monolaurate. There is general reference to use in the compositions of L-thyroxine or L-tri-iodothyronine tagged with I-125 or I-131.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36066073A | 1973-05-14 | 1973-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1428317A true GB1428317A (en) | 1976-03-17 |
Family
ID=23418929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1871774A Expired GB1428317A (en) | 1973-05-14 | 1974-04-29 | Method for in vitro determination of thyroid function and diagnostic reagent composition therefor |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5048986A (en) |
| BE (1) | BE814906A (en) |
| CA (1) | CA1028603A (en) |
| CH (1) | CH581320A5 (en) |
| DE (1) | DE2423174A1 (en) |
| FR (1) | FR2229973B3 (en) |
| GB (1) | GB1428317A (en) |
| IL (1) | IL44738A (en) |
| IT (1) | IT1021547B (en) |
| NL (1) | NL7406237A (en) |
-
1974
- 1974-04-29 GB GB1871774A patent/GB1428317A/en not_active Expired
- 1974-04-30 CA CA198,539A patent/CA1028603A/en not_active Expired
- 1974-04-30 IL IL44738A patent/IL44738A/en unknown
- 1974-05-09 NL NL7406237A patent/NL7406237A/xx not_active Application Discontinuation
- 1974-05-13 DE DE2423174A patent/DE2423174A1/en not_active Withdrawn
- 1974-05-13 JP JP49053162A patent/JPS5048986A/ja active Pending
- 1974-05-13 BE BE1005947A patent/BE814906A/en unknown
- 1974-05-14 CH CH659074A patent/CH581320A5/xx not_active IP Right Cessation
- 1974-05-14 IT IT50982/74A patent/IT1021547B/en active
- 1974-05-14 FR FR7416702A patent/FR2229973B3/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7406237A (en) | 1974-11-18 |
| FR2229973A1 (en) | 1974-12-13 |
| JPS5048986A (en) | 1975-05-01 |
| FR2229973B3 (en) | 1977-03-11 |
| IT1021547B (en) | 1978-02-20 |
| CH581320A5 (en) | 1976-10-29 |
| CA1028603A (en) | 1978-03-28 |
| IL44738A (en) | 1976-08-31 |
| DE2423174A1 (en) | 1974-12-05 |
| IL44738A0 (en) | 1974-06-30 |
| BE814906A (en) | 1974-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |