GB1422974A - Drying process - Google Patents

Drying process

Info

Publication number
GB1422974A
GB1422974A GB1689073A GB1689073A GB1422974A GB 1422974 A GB1422974 A GB 1422974A GB 1689073 A GB1689073 A GB 1689073A GB 1689073 A GB1689073 A GB 1689073A GB 1422974 A GB1422974 A GB 1422974A
Authority
GB
United Kingdom
Prior art keywords
spray
bloom
hydrolyzed gelatin
silicic acid
sodium benzoate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1689073A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1422974A publication Critical patent/GB1422974A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids

Abstract

1422974 Powders for tableting F HOFFMANN-LA ROCHE & CO AG 9 April 1973 [10 April 1972] 16890/73 Heading A5B [Also in Division B1] A free flowing, high density, agglomerated powder suitable for direct compression tableting techniques is prepared by spray drying wherein the spray of material to be spray dried is contacted during drying in the spray drier chamber with a powder spray comprising an absorbent material having particle sizes 2- 16Á. The absorbent material may be silicic and, silica gel, an alkali metal silicate, magnesium carbonate, kaolin clay or dicalcium phosphate. The following compositions may thus be made:- (a) 45-60% d, l alphatocopheryl acetate, 38-53% hydrolyzed gelatin having an O bloom and a M.W. of 9000-11000, C0.1% sodium benzoate, 0,2% of sorbic acid and 1-3% silicic acid (b) 15-30% vitamin A palmitate, 50-65% of hydrolyzed gelatin of low bloom, 10-20% sucrose, 2% - 6% of 1, 2 dihydroxy 6 ethoxy 2, 2, 4 trimethylquinoline and 1-5% silicic acid, (c) 45-65% riboflavin, 15-25% of a non absorbent inorganic filler, 15-35% hydrolyzed cereal flour and 1-5% silicic acid (d) 20%-30% of a flavour oil, 70-80% low bloom hydrolyzed gelatin and 1-3% silicic acid and (e) 45-60% of d, l alphatocopheryl acetate, 38-53% hydrolyzed gelatin having O bloom and a M.W. 9000-11000 C0.1% of sodium benzoate, C0.2% of sorbic acid and 1-2% of an absorbent comprising 4-12% of calcium silicate having a particle size of 3.4Á, an oil absorption capacity of 1-3 kg/kg and surface area of 175 m<SP>2</SP>/g. and 88-96% of a fine-particle sized spray-dried vitamin E composition, comprising 15-20% d, l alphatocopheryl acetate, 80-85% hydrolyzed gelatin of O bloom and M.W. of 9000-11000, C1% sodium benzoate and C0.7% sorbic acid.
GB1689073A 1972-04-10 1973-04-09 Drying process Expired GB1422974A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24278972A 1972-04-10 1972-04-10

Publications (1)

Publication Number Publication Date
GB1422974A true GB1422974A (en) 1976-01-28

Family

ID=22916188

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1689073A Expired GB1422974A (en) 1972-04-10 1973-04-09 Drying process

Country Status (8)

Country Link
JP (1) JPS5418331B2 (en)
AT (1) AT353232B (en)
BE (1) BE797921A (en)
CH (1) CH586568A5 (en)
DE (1) DE2317434A1 (en)
FR (1) FR2179899B1 (en)
GB (1) GB1422974A (en)
NL (1) NL7304921A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088382A1 (en) * 1982-03-09 1983-09-14 Nippon Shinyaku Company, Limited Stabilization of azulene derivatives
WO2008130883A1 (en) * 2007-04-16 2008-10-30 Wyeth Embedded liquid lubricants for tableting
EP1811008A3 (en) * 2006-01-18 2009-12-16 Joseph Iannicelli Method and composition for controlled heat release and disposable chemical heater utilizing same
US9891239B2 (en) 2007-02-23 2018-02-13 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
US10039718B2 (en) 2008-05-02 2018-08-07 Gilead Sciences, Inc. Use of solid carrier particles to improve the processability of a pharmaceutical agent

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2546838B2 (en) * 1986-03-24 1996-10-23 エフ・ホフマン―ラ ロシユ アーゲー Vitamin preparation manufacturing method
JP3555640B2 (en) * 1996-05-10 2004-08-18 ライオン株式会社 Multicapsulated microcapsules containing natural carotenoids, tablets, food and pharmaceutical compounds
EP1104290B1 (en) * 1998-08-13 2010-03-31 Cima Labs Inc. Microemulsions as solid dosage forms for oral administration
JP2000086537A (en) * 1998-09-11 2000-03-28 Fuji Chem Ind Co Ltd Inorganic compound saccharide composition, vehicle, rapidly disintegrating compression molded product, and their production
AU2001241730B2 (en) * 2001-02-23 2007-03-15 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
CN103402491B (en) * 2010-12-27 2015-11-25 帝斯曼知识产权资产管理有限公司 The powderous vitamin E preparation improved

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1266902A (en) * 1960-09-06 1961-07-17 Process for the production of stable vitamin preparations
FR1546920A (en) * 1966-12-02 1968-11-22 Niro Atomizer As Two-component simultaneous atomization wheel
US3608083A (en) * 1968-06-05 1971-09-21 Hoffmann La Roche Vitamin e powder

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088382A1 (en) * 1982-03-09 1983-09-14 Nippon Shinyaku Company, Limited Stabilization of azulene derivatives
EP1811008A3 (en) * 2006-01-18 2009-12-16 Joseph Iannicelli Method and composition for controlled heat release and disposable chemical heater utilizing same
US8080172B2 (en) 2006-01-18 2011-12-20 J.I. Enterprises, Inc. Method and composition for controlled heat release and disposable chemical heater utilizing same
US9891239B2 (en) 2007-02-23 2018-02-13 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
WO2008130883A1 (en) * 2007-04-16 2008-10-30 Wyeth Embedded liquid lubricants for tableting
AU2008242256B2 (en) * 2007-04-16 2011-11-03 Pf Consumer Healthcare 1 Llc Embedded liquid lubricants for tableting
EP2599394A1 (en) * 2007-04-16 2013-06-05 Wyeth LLC Embedded liquid lubricants for tableting
US11013251B2 (en) 2007-04-16 2021-05-25 PF Consumer Healthcare 1, LLC Embedded liquid lubricants for tableting
US10039718B2 (en) 2008-05-02 2018-08-07 Gilead Sciences, Inc. Use of solid carrier particles to improve the processability of a pharmaceutical agent

Also Published As

Publication number Publication date
FR2179899A1 (en) 1973-11-23
FR2179899B1 (en) 1976-09-10
NL7304921A (en) 1973-10-12
CH586568A5 (en) 1977-04-15
JPS497415A (en) 1974-01-23
AT353232B (en) 1979-11-12
JPS5418331B2 (en) 1979-07-06
DE2317434A1 (en) 1973-12-06
ATA310873A (en) 1979-04-15
BE797921A (en) 1973-10-09

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee