GB1421104A - Process for preparing aryloxyacetic thiolesters and aryloxyacetic thiolesters - Google Patents
Process for preparing aryloxyacetic thiolesters and aryloxyacetic thiolestersInfo
- Publication number
- GB1421104A GB1421104A GB1857674A GB1857674A GB1421104A GB 1421104 A GB1421104 A GB 1421104A GB 1857674 A GB1857674 A GB 1857674A GB 1857674 A GB1857674 A GB 1857674A GB 1421104 A GB1421104 A GB 1421104A
- Authority
- GB
- United Kingdom
- Prior art keywords
- mercaptan
- aryloxyacetic
- group
- thiolesters
- acid halide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1421104 Aryloxyacetic thiolesters J BLUM 29 April 1974 [4 May 1973] 18576/74 Heading C2C The invention comprises novel compounds of the general Formula (I): where Ph is an optionally substituted aryl group; R is an organic radical containing neither phenol nor mercaptan groups; R<SP>1</SP> is a hydrogen atom or hydrocarbon radical, preferably aliphatic; and R<SP>11</SP> is an aliphatic, cycloaliphatic, aromatic or heteroaromatic group, which is not aliphatic, when R<SP>1</SP> is hydrogen. In particular, the group SR is a group derived from (N-acetyl) homocystein, (N-acetyl) cystein, beta-mercaptoethanol, parachlorophenoxy-2-isobutyryl-O-mercaptoethanol or carboxymethylmercaptan. The compounds are made by process (a) in which an aqueous solution of a metallic salt of a mercaptan reacts with an optionally substituted aryloxyacetic acid halide of the formula PhOCR<SP>1</SP>R<SP>11</SP>COX, where X is halogen, or process (b) in which a substituted aryloxyacetic acid halide reacts with a mercaptan in an inert, neutral or basic organic medium, and the mercaptan and possibly phenol group or groups contained in the mercaptan react with the substituted aryloxyacetic acid halide. Pharmaceutical preparations having hypolipemic, hypocholesteiolemic, hepatoprotective, tonic, healing and mucolytic effects contain (I) as active ingredient. Administration is orally, rectally or parenterally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7316162A FR2227863B1 (en) | 1973-05-04 | 1973-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1421104A true GB1421104A (en) | 1976-01-14 |
Family
ID=9118832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1857674A Expired GB1421104A (en) | 1973-05-04 | 1974-04-29 | Process for preparing aryloxyacetic thiolesters and aryloxyacetic thiolesters |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5025536A (en) |
| AT (1) | AT333723B (en) |
| BE (1) | BE814365A (en) |
| BR (1) | BR7403549D0 (en) |
| DE (1) | DE2420667A1 (en) |
| ES (1) | ES425992A1 (en) |
| FR (1) | FR2227863B1 (en) |
| GB (1) | GB1421104A (en) |
| HU (1) | HU168005B (en) |
| LU (1) | LU69968A1 (en) |
| NL (1) | NL7406077A (en) |
| OA (1) | OA04703A (en) |
-
1973
- 1973-05-04 FR FR7316162A patent/FR2227863B1/fr not_active Expired
-
1974
- 1974-04-29 GB GB1857674A patent/GB1421104A/en not_active Expired
- 1974-04-29 BE BE6044563A patent/BE814365A/en unknown
- 1974-04-29 DE DE2420667A patent/DE2420667A1/en not_active Withdrawn
- 1974-04-30 LU LU69968A patent/LU69968A1/xx unknown
- 1974-04-30 BR BR3549/74A patent/BR7403549D0/en unknown
- 1974-05-02 OA OA55193A patent/OA04703A/en unknown
- 1974-05-02 JP JP49050182A patent/JPS5025536A/ja active Pending
- 1974-05-03 HU HUBU715A patent/HU168005B/hu unknown
- 1974-05-03 AT AT365374A patent/AT333723B/en not_active IP Right Cessation
- 1974-05-04 ES ES425992A patent/ES425992A1/en not_active Expired
- 1974-05-06 NL NL7406077A patent/NL7406077A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES425992A1 (en) | 1976-07-01 |
| DE2420667A1 (en) | 1974-11-21 |
| FR2227863A1 (en) | 1974-11-29 |
| ATA365374A (en) | 1976-04-15 |
| OA04703A (en) | 1980-08-31 |
| BE814365A (en) | 1974-08-16 |
| FR2227863B1 (en) | 1976-07-02 |
| NL7406077A (en) | 1974-11-06 |
| AT333723B (en) | 1976-12-10 |
| LU69968A1 (en) | 1974-08-06 |
| JPS5025536A (en) | 1975-03-18 |
| BR7403549D0 (en) | 1974-11-19 |
| HU168005B (en) | 1976-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |