GB1416785A - Mercaptans - Google Patents

Abstract

1416785 Mercaptans AMERICAN HOME PRODUCTS CORP 22 Feb 1973 [6 March 1972 (2)] 8711/73 Heading C2C The invention comprises novel compounds of general Formula (II) or (III) or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are independently hydrogen, C 1 to C 6 alkyl, C 1 to C 6 alkoxy, aryl of 6 to 10 carbon atoms, aralkyl of 7 to 10 carbon atoms, C 1 to C 6 alkoxyaryl of 7 to 14 carbon atoms, 2-pyridyl, trifluoromethyl, fluoro, chloro, bromo, iodo, nitro, amino, hydroxy, di(C 1 to C 6 )alkylamino, carbamyl, sulphamyl, carb(C 1 to C 6 )- alkoxy, C 1 to C 6 alkylthio, C 1 to C 6 alkylsulphonyl, carboxy(C 1 to C 6 )alkyl, carboxyl, C 1 to C 6 alkanolyamido or, when taken together, the ortho fused 1,3-butadienylene radical, Y is -NH(C 1 to C 6 alkoxy), -NHalkoxyaryl, -NHNH 2 , NHOH, -NH(2-pyridyl), where R 5 is hydrogen, C 1 to C 6 alkyl, aryl of 6 to 10 carbon atoms or aralkyl of 6 to 14 carbon atoms, R 6 and R 7 are independently hydrogen, C 1 to C 6 alkyl, aryl of 6 to 10 carbon atoms, (C 1 to C 6 )alkoxyaryl of 7 to 11 carbon atoms, aralkyl of 7 to 11 carbon atoms, azacycloalkyl of 4 to 6 carbon atoms, an azacarbocyclic aromatic radical of 5 to 9 carbon atoms, hydroxy, mercapto, C 1 to C 6 alkoxy, C 1 to C 6 alkylthio, C 1 to C 6 alkylsulphonyl, trifluoromethyl, fluoro, chloro, bromo, iodo, nitro, -SCN, amino, di- (C 1 to C 6 )alkyl amino, -CONH 2 -SO 2 NH 2 , carboxy(C 1 to C 6 )alkyl, carboxy, (C 1 to C 6 )- alkanoylamido, or, when taken together, the ortho-fused 1,3-butadienylene radical; R 8 and R 9 are independently hydrogen, C 1 to C 6 alkyl, C 1 to C 6 alkoxy, aryl of 6 to 10 carbon atoms, p- (C 1 to C 6 )alkoxyaryl of 7 to 11 carbon atoms, aralkyl of 7 to 11 carbon atoms, azacycloalkyl of 4 to 6 carbon atoms, an azacarbocyclic aromatic radical of 5 to 9 carbon atoms, trifluoromethyl, fluoro, chloro, bromo or iodo and x is 2. Pharmaceutical preparations having hypoglycaemic, anti-inflammatory and CNS actions contain compounds (II) and/or (III) as active ingredient but wherein x is 1 to 5 and Y is a radical of the formula -NR 3 R 4 (where R 3 is hydrogen, C 1 to C 6 alkyl or and R 4 is hydrogen or C 1 to C 6 alkyl) or or of Formula A above -NH.NH 2 , -NHOH, -NHaryl of 6 to 10 carbon atoms, -NH aralkyl of 7 to 14 carbon atoms, -NH(2- pyridyl), or of Formula B, C and D above, where R 5 is hydrogen, C 1 to C 6 alkyl, aryl of 6 to 10 carbon atoms or aralkyl of 6 to 14 carbon atoms. Administration is orally or parenterally.