GB1416427A - Alkylated pregnanes and process for obtaining same - Google Patents

Alkylated pregnanes and process for obtaining same

Info

Publication number
GB1416427A
GB1416427A GB153472A GB153472A GB1416427A GB 1416427 A GB1416427 A GB 1416427A GB 153472 A GB153472 A GB 153472A GB 153472 A GB153472 A GB 153472A GB 1416427 A GB1416427 A GB 1416427A
Authority
GB
United Kingdom
Prior art keywords
group
oxo
alkyl
halo
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB153472A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Priority to GB153472A priority Critical patent/GB1416427A/en
Priority to IL41160A priority patent/IL41160A/en
Priority to IE1799/72A priority patent/IE37048B1/xx
Priority to US320777A priority patent/US3862194A/en
Priority to CH24473A priority patent/CH615934A5/de
Priority to HUAO347A priority patent/HU167205B/hu
Priority to NLAANVRAGE7300313,A priority patent/NL179287C/xx
Priority to PH14245*UA priority patent/PH9719A/en
Priority to CA161,016A priority patent/CA1022158A/en
Priority to DE2301317A priority patent/DE2301317C2/de
Priority to DK15373AA priority patent/DK139031B/da
Priority to FI730078A priority patent/FI52587C/fi
Priority to SE7300347A priority patent/SE411213B/xx
Priority to JP626673A priority patent/JPS5614678B2/ja
Priority to BE793958D priority patent/BE793958A/xx
Priority to FR7301022A priority patent/FR2168006B1/fr
Priority to AT0028373A priority patent/AT367068B/de
Priority to US05/526,204 priority patent/US3947478A/en
Publication of GB1416427A publication Critical patent/GB1416427A/en
Priority to NL930031C priority patent/NL930031I1/nl
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB153472A 1972-01-12 1972-01-12 Alkylated pregnanes and process for obtaining same Expired GB1416427A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
GB153472A GB1416427A (en) 1972-01-12 1972-01-12 Alkylated pregnanes and process for obtaining same
IL41160A IL41160A (en) 1972-01-12 1972-12-25 21-alkyl-delta4-pregnene-3,20-dione derivatives and their preparation
IE1799/72A IE37048B1 (en) 1972-01-12 1972-12-28 Novel alkylated pregnanes
US320777A US3862194A (en) 1972-01-12 1973-01-03 Alkylated 3,20-diketo-d{hu 4{b -steroids of the pregnane series
CH24473A CH615934A5 (enExample) 1972-01-12 1973-01-09
HUAO347A HU167205B (enExample) 1972-01-12 1973-01-10
NLAANVRAGE7300313,A NL179287C (nl) 1972-01-12 1973-01-10 Werkwijze voor het bereiden van steroiden van de pregnaanreeks, werkwijze ter bereiding van farmaceutische preparaten en gevormd geneesmiddel.
PH14245*UA PH9719A (en) 1972-01-12 1973-01-10 Alkylated pregnanes
DE2301317A DE2301317C2 (de) 1972-01-12 1973-01-11 Alkylierte 3,20-Diketo-Δ↑4↑-steroide der Pregnanreihe und Verfahren zu deren Herstellung
CA161,016A CA1022158A (en) 1972-01-12 1973-01-11 Alkylated pregnanes and process for obtaining same
DK15373AA DK139031B (da) 1972-01-12 1973-01-11 Analogifremgangsmåde til fremstilling af i 21-stillingen alkylerede 3,20-dioxo-delta4-steroider af pregnanrækken.
FI730078A FI52587C (fi) 1972-01-12 1973-01-11 Menetelmä pregnaanisarjan uusien, tulehduksenvastaisten, 21-asemassa a lkyloitujen 3,20-delta4-steroidien valmistamiseksi
SE7300347A SE411213B (sv) 1972-01-12 1973-01-11 Sett att framstella i 21-stellning monoalkylerade steroider ur pregnanserien
JP626673A JPS5614678B2 (enExample) 1972-01-12 1973-01-11
BE793958D BE793958A (fr) 1972-01-12 1973-01-12 Nieuwe gealkyleerde steroiden van de pregnaanreeks
FR7301022A FR2168006B1 (enExample) 1972-01-12 1973-01-12
AT0028373A AT367068B (de) 1972-01-12 1973-01-12 Verfahren zur herstellung neuer alkylierter 3,20-diketo-delta 4-steroide der pregnanreihe
US05/526,204 US3947478A (en) 1972-01-12 1974-11-22 Alkylated 3,20-diketo-Δ4 -steroids of the pregnane series
NL930031C NL930031I1 (nl) 1972-01-12 1993-04-28 Werkwijze voor het bereiden van steroïden van de pregnaanreeks werkwijze ter bereiding van farmaceutische preparaten en gevormd geneesmiddel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB153472A GB1416427A (en) 1972-01-12 1972-01-12 Alkylated pregnanes and process for obtaining same

Publications (1)

Publication Number Publication Date
GB1416427A true GB1416427A (en) 1975-12-03

Family

ID=9723658

Family Applications (1)

Application Number Title Priority Date Filing Date
GB153472A Expired GB1416427A (en) 1972-01-12 1972-01-12 Alkylated pregnanes and process for obtaining same

Country Status (17)

Country Link
US (1) US3862194A (enExample)
JP (1) JPS5614678B2 (enExample)
AT (1) AT367068B (enExample)
BE (1) BE793958A (enExample)
CA (1) CA1022158A (enExample)
CH (1) CH615934A5 (enExample)
DE (1) DE2301317C2 (enExample)
DK (1) DK139031B (enExample)
FI (1) FI52587C (enExample)
FR (1) FR2168006B1 (enExample)
GB (1) GB1416427A (enExample)
HU (1) HU167205B (enExample)
IE (1) IE37048B1 (enExample)
IL (1) IL41160A (enExample)
NL (2) NL179287C (enExample)
PH (1) PH9719A (enExample)
SE (1) SE411213B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260605A (en) * 1979-01-24 1981-04-07 Akzo N.V. Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947478A (en) * 1972-01-12 1976-03-30 Akzona Incorporated Alkylated 3,20-diketo-Δ4 -steroids of the pregnane series
GB1436324A (en) * 1972-05-12 1976-05-19 Glaxo Lab Ltd Anaesthetic 3alpha-hydroxy pregnanes
GB1478968A (en) * 1973-07-11 1977-07-06 Akzo Nv Alkylated pregnanes
US4031075A (en) * 1973-07-11 1977-06-21 Akzona Incorporated Alkylated pregnanes and process for obtaining same
JPS5264666A (en) * 1975-11-25 1977-05-28 Sharp Kk Bothhside circuit substrate
JPS58194A (ja) * 1981-06-25 1983-01-05 北陸電気工業株式会社 Ｃｕ粉末導電塗料を用いた印刷抵抗回路基板の製造方法
US4686214A (en) * 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
AU7556291A (en) * 1990-03-27 1991-10-21 Schering Corporation Process for 9alpha-hydroxy steroid dehydration
PL327141A1 (en) * 1995-12-20 1998-11-23 Schering Corp Method of obtaining 9,11 beta-epoxysteroides
US6040468A (en) * 1996-10-25 2000-03-21 Alcon Laboratories, Inc. Method of preparing 16α, 17α-dialkylated steroids
JP2000502370A (ja) * 1996-10-25 2000-02-29 アルコン ラボラトリーズ，インコーポレイテッド ２１―アルキル化プレグナ−１，４，１６―トリエン―３，２０―ジオンを調製する方法
CA2290775A1 (en) * 1997-06-04 1998-12-10 Akzo Nobel Nv Use of anti-inflammatory steroids for the treatment of chronic inflammatory intestinal diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3064017A (en) * 1962-11-13 Preparation viii
US3047594A (en) * 1960-05-11 1962-07-31 Pfizer & Co C Preparation of 21-methyl steroids and intermediates
US3114750A (en) * 1960-11-07 1963-12-17 British Drug Houses Ltd 3-enol ethers of 6-formyl-3-oxo-delta4-steroids and process for their preparation
US3166551A (en) * 1962-01-02 1965-01-19 British Drug Houses Ltd Process for the preparation of 3-oxo-delta4-6-methyl steroids
DE1167829B (de) * 1962-08-03 1964-04-16 Schering Ag Verfahren zur Herstellung von 21-Methyl-í¸-pregnen-11ª‰, 17ª‡-diol-3, 20-dion
US3594407A (en) * 1969-04-03 1971-07-20 American Home Prod 13,17-dialkyl-19-norpregn-4-ene,3,20-diones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260605A (en) * 1979-01-24 1981-04-07 Akzo N.V. Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same

Also Published As

Publication number Publication date
PH9719A (en) 1976-02-27
FR2168006B1 (enExample) 1976-09-03
NL179287C (nl) 1986-08-18
DE2301317A1 (de) 1973-07-26
FI52587C (fi) 1977-10-10
CA1022158A (en) 1977-12-06
US3862194A (en) 1975-01-21
JPS504060A (enExample) 1975-01-16
JPS5614678B2 (enExample) 1981-04-06
BE793958A (fr) 1973-07-12
IE37048L (en) 1973-07-12
IL41160A0 (en) 1973-02-28
CH615934A5 (enExample) 1980-02-29
IE37048B1 (en) 1977-04-27
ATA28373A (de) 1981-10-15
HU167205B (enExample) 1975-09-27
NL7300313A (enExample) 1973-07-16
DK139031B (da) 1978-12-04
AT367068B (de) 1982-05-25
NL930031I1 (nl) 1993-07-01
SE411213B (sv) 1979-12-10
DK139031C (enExample) 1979-05-14
FR2168006A1 (enExample) 1973-08-24
NL179287B (nl) 1986-03-17
FI52587B (enExample) 1977-06-30
IL41160A (en) 1977-04-29
DE2301317C2 (de) 1983-11-03

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19930103