GB1409034A - Process for the manufacture of benzyl-pyrimidine derivatives - Google Patents
Process for the manufacture of benzyl-pyrimidine derivativesInfo
- Publication number
- GB1409034A GB1409034A GB842074A GB842074A GB1409034A GB 1409034 A GB1409034 A GB 1409034A GB 842074 A GB842074 A GB 842074A GB 842074 A GB842074 A GB 842074A GB 1409034 A GB1409034 A GB 1409034A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkoxy
- compounds
- formula
- benzyloxy
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OOLOAWZLPBDRJQ-UHFFFAOYSA-N 2-benzylpyrimidine Chemical class N=1C=CC=NC=1CC1=CC=CC=C1 OOLOAWZLPBDRJQ-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 7
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 abstract 2
- -1 methylenedioxy group Chemical group 0.000 abstract 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- LDBTVAXGKYIFHO-UHFFFAOYSA-N diaveridine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=CN=C(N)N=C1N LDBTVAXGKYIFHO-UHFFFAOYSA-N 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33609473A | 1973-02-26 | 1973-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1409034A true GB1409034A (en) | 1975-10-08 |
Family
ID=23314538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB842074A Expired GB1409034A (en) | 1973-02-26 | 1974-02-25 | Process for the manufacture of benzyl-pyrimidine derivatives |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5939429B2 (enrdf_load_stackoverflow) |
| AT (1) | AT338272B (enrdf_load_stackoverflow) |
| BE (1) | BE811504A (enrdf_load_stackoverflow) |
| CH (1) | CH592066A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2405683A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2219162B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1409034A (enrdf_load_stackoverflow) |
| NL (1) | NL180104C (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4723006A (en) * | 1982-10-15 | 1988-02-02 | Ciba-Geigy Corporation | Process for 4,6-di-substituted 2-aminopyrimidines |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5888368A (ja) * | 1981-11-09 | 1983-05-26 | ザ・ウエルカム・フアウンデ−シヨン・リミテツド | ベンジルピリミジン誘導体の製造法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD94818A5 (enrdf_load_stackoverflow) * | 1970-10-22 | 1973-01-05 | ||
| BE789904A (fr) * | 1971-10-12 | 1973-04-10 | Wellcome Found | Procedes de synthese organique |
-
1974
- 1974-01-22 CH CH81874A patent/CH592066A5/xx not_active IP Right Cessation
- 1974-02-06 DE DE19742405683 patent/DE2405683A1/de not_active Ceased
- 1974-02-08 NL NL7401764A patent/NL180104C/xx not_active IP Right Cessation
- 1974-02-21 JP JP49020031A patent/JPS5939429B2/ja not_active Expired
- 1974-02-25 GB GB842074A patent/GB1409034A/en not_active Expired
- 1974-02-25 AT AT151974A patent/AT338272B/de not_active IP Right Cessation
- 1974-02-25 FR FR7406324A patent/FR2219162B1/fr not_active Expired
- 1974-02-25 BE BE141324A patent/BE811504A/xx not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4723006A (en) * | 1982-10-15 | 1988-02-02 | Ciba-Geigy Corporation | Process for 4,6-di-substituted 2-aminopyrimidines |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2219162B1 (enrdf_load_stackoverflow) | 1977-09-16 |
| FR2219162A1 (enrdf_load_stackoverflow) | 1974-09-20 |
| CH592066A5 (enrdf_load_stackoverflow) | 1977-10-14 |
| DE2405683A1 (de) | 1974-09-05 |
| BE811504A (fr) | 1974-08-26 |
| ATA151974A (de) | 1976-12-15 |
| NL180104B (nl) | 1986-08-01 |
| AT338272B (de) | 1977-08-10 |
| NL180104C (nl) | 1987-01-02 |
| JPS49117478A (enrdf_load_stackoverflow) | 1974-11-09 |
| NL7401764A (enrdf_load_stackoverflow) | 1974-08-28 |
| JPS5939429B2 (ja) | 1984-09-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1133766A (en) | Novel acetals and a process for the manufacture and conversion thereof | |
| DK0584903T3 (da) | Fremgangsmåde til fremstilling af arylpiperazinyl-heterocykliske forbindelser | |
| JPS562968A (en) | Novel pyrimidine derivative | |
| GB1409034A (en) | Process for the manufacture of benzyl-pyrimidine derivatives | |
| GB1398773A (en) | Bis-basic ketones of phenoxathiins and antiviral compositions thereof | |
| GB1457038A (en) | Amino derivatives of 1,4-benzodioxan | |
| ES8404341A1 (es) | "un procedimiento para preparar espiro benzofuran-2(3h), 1- cicloalcanos sustituidos en posicion 2". | |
| ES8307236A1 (es) | Un procedimiento para la preparacion de ranitidina. | |
| US4277399A (en) | Process for preparing pyrenzepine | |
| JPS5731671A (en) | Preparation of homopiperazine derivative | |
| JPS5473732A (en) | Production of thiol carbamate | |
| MY105374A (en) | A process for the preparation of 7-amino-3-methoxymeth- yl-ceph-3-em-4-carboxylic acid. | |
| JPS5740479A (en) | Preparation of benzofuran derivative and its acid addition salt | |
| JPS5795966A (en) | Novel 2(1h)-quinazolinone derivative | |
| GB1413459A (en) | Process for the production of 2,4-diamono-5-benzyl pyrimidines | |
| JPS57142929A (en) | Forming method of dipentaerythritol or ditrimethylolalkane as by-product at given ratio | |
| GB1419407A (enrdf_load_stackoverflow) | ||
| IE40333L (en) | Pyridine derivatives. | |
| GB1477347A (en) | Substituted ureido-s-triazines and process for their pre paration | |
| JPS5677278A (en) | Theobromine derivative | |
| JPS5782350A (en) | Preparation of acid amide | |
| JPS55110161A (en) | Production of basic dye | |
| GB1526235A (en) | Preparation of pyrimidines | |
| GB1426310A (en) | N-substituted cycloserine compounds | |
| JPS56147780A (en) | 3-allyl-5-hydroxymethyltetrahydrofuran-2-ones |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429H | Application (made) for amendment of specification now open to opposition (sect. 29/1949) | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429D | Case decided by the comptroller ** specification amended (sect. 29/1949) | ||
| SP | Amendment (slips) printed | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19940224 |