GB1399261A - 1,3-diamino 2-propanols and process for their preparation - Google Patents
1,3-diamino 2-propanols and process for their preparationInfo
- Publication number
- GB1399261A GB1399261A GB323772A GB323772A GB1399261A GB 1399261 A GB1399261 A GB 1399261A GB 323772 A GB323772 A GB 323772A GB 323772 A GB323772 A GB 323772A GB 1399261 A GB1399261 A GB 1399261A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- optionally substituted
- radical
- optionally
- jan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UYBWIEGTWASWSR-UHFFFAOYSA-N 1,3-diaminopropan-2-ol Chemical class NCC(O)CN UYBWIEGTWASWSR-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- CKNOLMVLQUPVMU-XOMFLMSUSA-N Digitalin Natural products O(C)[C@H]1[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@@H]([C@H](O)C5)C5=CC(=O)OC5)CC4)CC3)CC2)[C@@H]1O CKNOLMVLQUPVMU-XOMFLMSUSA-N 0.000 abstract 1
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 abstract 1
- CPFNIKYEDJFRAT-UHFFFAOYSA-N Strospasid Natural products OC1C(OC)C(O)C(C)OC1OC1CC(CCC2C3(CC(O)C(C3(C)CCC32)C=2COC(=O)C=2)O)C3(C)CC1 CPFNIKYEDJFRAT-UHFFFAOYSA-N 0.000 abstract 1
- CKNOLMVLQUPVMU-UHFFFAOYSA-N UNPD183315 Natural products O1C(C)C(OC2C(C(O)C(O)C(CO)O2)O)C(OC)C(O)C1OC(C1)CCC2(C)C1CCC(C1(CC3O)O)C2CCC1(C)C3C1=CC(=O)OC1 CKNOLMVLQUPVMU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- -1 alkyl radical Chemical class 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229940127090 anticoagulant agent Drugs 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 239000003218 coronary vasodilator agent Substances 0.000 abstract 1
- CKNOLMVLQUPVMU-YMMLYESFSA-N digitalin Chemical compound C1([C@@H]2[C@@]3(C)CC[C@H]4[C@H]([C@]3(C[C@@H]2O)O)CC[C@H]2[C@]4(C)CC[C@@H](C2)O[C@H]2[C@H](O)[C@H]([C@H]([C@@H](C)O2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)OC)=CC(=O)OC1 CKNOLMVLQUPVMU-YMMLYESFSA-N 0.000 abstract 1
- 229950004590 digitalin Drugs 0.000 abstract 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 abstract 1
- 229960002768 dipyridamole Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229960002822 ethyl biscoumacetate Drugs 0.000 abstract 1
- SEGSDVUVOWIWFX-UHFFFAOYSA-N ethyl biscoumacetate Chemical compound C1=CC=C2C(=O)C(C(C=3C(C4=CC=CC=C4OC=3O)=O)C(=O)OCC)=C(O)OC2=C1 SEGSDVUVOWIWFX-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- DURULFYMVIFBIR-UHFFFAOYSA-N practolol Chemical compound CC(C)NCC(O)COC1=CC=C(NC(C)=O)C=C1 DURULFYMVIFBIR-UHFFFAOYSA-N 0.000 abstract 1
- 229960001749 practolol Drugs 0.000 abstract 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003087 receptor blocking agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE794424D BE794424A (fr) | 1972-01-24 | Nouveaux dibenzocycloheptenes, leur procede d'obtention et leur application comme medicament | |
| GB323772A GB1399261A (en) | 1972-01-24 | 1972-01-24 | 1,3-diamino 2-propanols and process for their preparation |
| ZA730444A ZA73444B (en) | 1972-01-24 | 1973-01-22 | New disubstituted,1,3-diamino 2-propanols and process for preparing them |
| AU51316/73A AU487391B2 (en) | 1972-01-24 | 1973-01-22 | New 1, 3-diamino 2-propanols and process for their preparation |
| FI175/73A FI55179C (fi) | 1972-01-24 | 1973-01-23 | Foerfarande foer framstaellning av farmakologiskt aktiva substituerade dibensocyklohepten-karboxamider och deras syra-additionssalter |
| SE7300922A SE397190B (sv) | 1972-01-24 | 1973-01-23 | Sett att framstella substituerade dibensocykloheptener |
| NO277/73A NO141555C (no) | 1972-01-24 | 1973-01-23 | Analogifremgangsmaate for fremstilling av nye terapeutisk virksomme dibenzocykloheptenkarboksamider |
| JP48009799A JPS511706B2 (US07696358-20100413-C00002.png) | 1972-01-24 | 1973-01-23 | |
| FR7302202A FR2169135B1 (US07696358-20100413-C00002.png) | 1972-01-24 | 1973-01-23 | |
| NL737300960A NL149485B (nl) | 1972-01-24 | 1973-01-23 | Werkwijze voor de bereiding van 5h-dibenzo (a,d) cyclohepteen-5-carbonamiden en 10, 11-dihydro-5h-dibenzo (a,d)-cyclohepteen-5-carbonamiden, een werkwijze voor de bereiding van een geneesmiddel met anti-aritmische en anti-hypertensieve werking, alsmede een dergelijk geneesmiddel. |
| IE108/73A IE37140B1 (en) | 1972-01-24 | 1973-01-23 | New 1,3 - diamino 2-propanols and process for their preparation |
| DK35073AA DK138943B (da) | 1972-01-24 | 1973-01-23 | Analogifremgangsmåde til fremstilling af substituerede dibenzocyclohepten-carboxamider eller syreadditionssalte deraf. |
| CH92573A CH562780A5 (US07696358-20100413-C00002.png) | 1972-01-24 | 1973-01-23 | |
| CA161,848A CA995212A (fr) | 1972-01-24 | 1973-01-23 | Procede pour la preparation des nouveaux dibenzocycloheptenes substitues |
| SU1873914A SU495822A3 (ru) | 1972-01-24 | 1973-01-24 | Способ получени замещенных дибензоциклогептенов |
| US326362A US3906040A (en) | 1972-01-24 | 1973-01-24 | Dibenzocycloheptenes substituted |
| HUSI1289A HU168110B (US07696358-20100413-C00002.png) | 1972-01-24 | 1973-01-24 | |
| DE2303427A DE2303427C3 (de) | 1972-01-24 | 1973-01-24 | Dibenzo-(a,d)-cycloheptadiene und -triene, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| NL7601019A NL7601019A (nl) | 1972-01-24 | 1976-02-02 | Werkwijze voor de bereiding van 5h-di- benzo (a,d) cyclohepteencarbonamiden en 10,11-di- hydro-5h-dibenzo (a,d)-cyclohepteencarbonamiden, een werkwijze voor de bereiding van een geneesmid- del met anti-arytmische en anti-hypertensieve wer- king alsmede een dergelijk geneesmiddel. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB323772A GB1399261A (en) | 1972-01-24 | 1972-01-24 | 1,3-diamino 2-propanols and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1399261A true GB1399261A (en) | 1975-07-02 |
Family
ID=9754539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB323772A Expired GB1399261A (en) | 1972-01-24 | 1972-01-24 | 1,3-diamino 2-propanols and process for their preparation |
Country Status (17)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1374366A (en) * | 1972-07-21 | 1974-11-20 | Science Union & Cie | Propanol derivatives and a process for their preparation |
| DE2720915C2 (de) * | 1977-05-10 | 1986-04-17 | Kali-Chemie Pharma Gmbh, 3000 Hannover | N↓1↓-Acyl-2-hydroxy-1,3-diaminopropane und Arzneimittel mit diesen Verbindungen als Wirkstoff |
| ES469020A1 (es) * | 1977-05-10 | 1979-09-01 | Kali Chemie Pharma Gmbh | Procedimiento para la preparacion de nuevos 1-acil-2-hidroxi-1,3-diaminopropanos |
| PT910563E (pt) * | 1995-06-29 | 2003-09-30 | Smithkline Beecham Corp | Antagonistas de receptores de integrina |
| US6008213A (en) * | 1995-06-29 | 1999-12-28 | Smithkline Beecham Corporation | Integrin receptor antagonists |
| CO4920232A1 (es) * | 1997-01-08 | 2000-05-29 | Smithkline Beecham Corp | Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin |
| RU2560727C1 (ru) * | 2014-09-22 | 2015-08-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") | Способ получения 1,3-дикарбонильных соединений, содержащих дибензосуберенильный фрагмент |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3287409A (en) * | 1962-07-23 | 1966-11-22 | Geigy Chem Corp | 5h-dibenzo [a, d] cycloheptene-5-carboxamide |
| US3344185A (en) * | 1962-07-30 | 1967-09-26 | Leonard Frederick | Certain amides of 5h-dibenzo [a, d] cycloheptene- and 10, 11-dihydro-5h-dibenzo [a, d] cycloheptene-5-carboxylic acid |
| CH443281A (de) * | 1964-02-18 | 1967-09-15 | Hoffmann La Roche | Verfahren zur Herstellung von Dibenzocycloheptatrienverbindungen |
-
0
- BE BE794424D patent/BE794424A/xx unknown
-
1972
- 1972-01-24 GB GB323772A patent/GB1399261A/en not_active Expired
-
1973
- 1973-01-22 ZA ZA730444A patent/ZA73444B/xx unknown
- 1973-01-23 DK DK35073AA patent/DK138943B/da unknown
- 1973-01-23 NL NL737300960A patent/NL149485B/xx not_active IP Right Cessation
- 1973-01-23 JP JP48009799A patent/JPS511706B2/ja not_active Expired
- 1973-01-23 CA CA161,848A patent/CA995212A/fr not_active Expired
- 1973-01-23 SE SE7300922A patent/SE397190B/xx unknown
- 1973-01-23 FR FR7302202A patent/FR2169135B1/fr not_active Expired
- 1973-01-23 CH CH92573A patent/CH562780A5/xx not_active IP Right Cessation
- 1973-01-23 IE IE108/73A patent/IE37140B1/xx unknown
- 1973-01-23 NO NO277/73A patent/NO141555C/no unknown
- 1973-01-23 FI FI175/73A patent/FI55179C/fi active
- 1973-01-24 US US326362A patent/US3906040A/en not_active Expired - Lifetime
- 1973-01-24 DE DE2303427A patent/DE2303427C3/de not_active Expired
- 1973-01-24 SU SU1873914A patent/SU495822A3/ru active
- 1973-01-24 HU HUSI1289A patent/HU168110B/hu unknown
-
1976
- 1976-02-02 NL NL7601019A patent/NL7601019A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO141555C (no) | 1980-04-09 |
| CH562780A5 (US07696358-20100413-C00002.png) | 1975-06-13 |
| SE397190B (sv) | 1977-10-24 |
| NL7300960A (US07696358-20100413-C00002.png) | 1973-07-26 |
| FR2169135A1 (US07696358-20100413-C00002.png) | 1973-09-07 |
| US3906040A (en) | 1975-09-16 |
| FI55179B (fi) | 1979-02-28 |
| DK138943C (US07696358-20100413-C00002.png) | 1979-05-07 |
| FR2169135B1 (US07696358-20100413-C00002.png) | 1976-04-09 |
| DK138943B (da) | 1978-11-20 |
| DE2303427C3 (de) | 1979-07-26 |
| DE2303427A1 (de) | 1973-08-16 |
| SU495822A3 (ru) | 1975-12-15 |
| NO141555B (no) | 1979-12-27 |
| CA995212A (fr) | 1976-08-17 |
| DE2303427B2 (de) | 1978-11-23 |
| AU5131673A (en) | 1974-07-25 |
| NL149485B (nl) | 1976-05-17 |
| BE794424A (fr) | 1973-07-23 |
| NL7601019A (nl) | 1976-05-31 |
| ZA73444B (en) | 1973-11-28 |
| JPS4881846A (US07696358-20100413-C00002.png) | 1973-11-01 |
| IE37140L (en) | 1973-07-24 |
| FI55179C (fi) | 1979-06-11 |
| IE37140B1 (en) | 1977-05-11 |
| HU168110B (US07696358-20100413-C00002.png) | 1976-02-28 |
| JPS511706B2 (US07696358-20100413-C00002.png) | 1976-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |