GB1066266A - Diazepine derivatives - Google Patents

Diazepine derivatives

Info

Publication number
GB1066266A
GB1066266A GB41742/64A GB4174264A GB1066266A GB 1066266 A GB1066266 A GB 1066266A GB 41742/64 A GB41742/64 A GB 41742/64A GB 4174264 A GB4174264 A GB 4174264A GB 1066266 A GB1066266 A GB 1066266A
Authority
GB
United Kingdom
Prior art keywords
compound
diazepine
alkyl
dibenzo
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB41742/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wander AG
Original Assignee
Wander AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wander AG filed Critical Wander AG
Publication of GB1066266A publication Critical patent/GB1066266A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Compounds of formula <FORM:1066266/C2/1> where X is alkylene of 2-4 C, R1 is hydrogen or alkyl of 1-3 C, and R2 is alkyl of 1-3 C, and therapeutically acceptable acid addition salts thereof, are prepared by (1) splitting off hydrogenolytically a protective group R3 from an -X-NR2R3 compound, (2) reacting a reactive ester of an -XOH compound with a monoalkylamine or (3) desalkylating a corresponding di-(lower alkyl)-amino compound. Diazepine derivatives also prepared are: 10 - (b - methylamino - ethyl) - 1,2,3,4,10,11,eoctahydro - 11 - oxo - 5H - dibenzo[b, e][1,4]diazepine; 5 - methyl - 10 - b - hydroxyethyl - 10,11 - dihydro - 11 - oxo - 5H - dibenzo[b, e][1,4]diazepine and the corresponding 10-b chloroethyl compound and the 10-g -chloropropyl compound. Pharmaceutical compositions are described containing the compounds of the invention with carriers (e.g. for oral or parenteral administration), being useful as antidepressives.
GB41742/64A 1963-10-24 1964-10-13 Diazepine derivatives Expired GB1066266A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1303263A CH442327A (en) 1963-10-24 1963-10-24 Process for the preparation of basic substituted 10,11-dihydro-11-oxo-5H-dibenzo (b, e) (1,4) diazepines

Publications (1)

Publication Number Publication Date
GB1066266A true GB1066266A (en) 1967-04-26

Family

ID=4388684

Family Applications (1)

Application Number Title Priority Date Filing Date
GB41742/64A Expired GB1066266A (en) 1963-10-24 1964-10-13 Diazepine derivatives

Country Status (11)

Country Link
AT (2) AT251587B (en)
BE (1) BE654761A (en)
BR (1) BR6463560D0 (en)
CH (1) CH442327A (en)
DE (1) DE1283847B (en)
DK (3) DK107169C (en)
ES (1) ES304772A1 (en)
FR (1) FR3931M (en)
GB (1) GB1066266A (en)
NL (1) NL6412380A (en)
SE (1) SE317084B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT231455B (en) * 1959-09-22 1964-01-27 Wander Ag Dr A Process for the preparation of new diazepine derivatives
AT229877B (en) * 1960-12-23 1963-10-25 Parke Davis & Co Process for the preparation of new 7-substituted 10-aminoethyldibenzo [b, e] [1, 4] diazepin-11 (10 H) ones

Also Published As

Publication number Publication date
AT250974B (en) 1966-12-12
AT251587B (en) 1967-01-10
FR3931M (en) 1966-02-14
DE1283847B (en) 1968-11-28
BE654761A (en) 1900-01-01
NL6412380A (en) 1965-04-26
DK107169C (en) 1967-05-01
DK109806C (en) 1968-07-08
ES304772A1 (en) 1965-04-01
CH442327A (en) 1967-08-31
BR6463560D0 (en) 1973-07-17
SE317084B (en) 1969-11-10
DK107170C (en) 1967-05-01

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