GB1398426A - Heterocyclic substituted guanidines - Google Patents

Heterocyclic substituted guanidines

Info

Publication number
GB1398426A
GB1398426A GB4116172A GB4116172A GB1398426A GB 1398426 A GB1398426 A GB 1398426A GB 4116172 A GB4116172 A GB 4116172A GB 4116172 A GB4116172 A GB 4116172A GB 1398426 A GB1398426 A GB 1398426A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
alkyl
prepared
methylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4116172A
Other languages
English (en)
Inventor
G J Emmet J C Ganellin Durant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Priority to GB4116172A priority Critical patent/GB1398426A/en
Priority to IL42879A priority patent/IL42879A/en
Priority to CA177,944A priority patent/CA1053242A/en
Priority to AU58906/73A priority patent/AU473158B2/en
Priority to NL7310836A priority patent/NL7310836A/xx
Priority to IE1467/73A priority patent/IE38123B1/xx
Priority to BE135044A priority patent/BE804145A/xx
Priority to HUSI1341A priority patent/HU166637B/hu
Priority to FR7331884A priority patent/FR2199466B2/fr
Priority to JP10012673A priority patent/JPS5732062B2/ja
Priority to DE2344833A priority patent/DE2344833C2/de
Priority to US05/558,532 priority patent/US3971786A/en
Priority to US05/560,909 priority patent/US4000296A/en
Publication of GB1398426A publication Critical patent/GB1398426A/en
Priority to US05/673,516 priority patent/US4060621A/en
Priority to US05/726,356 priority patent/US4083988A/en
Priority to US05/726,331 priority patent/US4072748A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB4116172A 1972-09-05 1972-09-05 Heterocyclic substituted guanidines Expired GB1398426A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB4116172A GB1398426A (en) 1972-09-05 1972-09-05 Heterocyclic substituted guanidines
IL42879A IL42879A (en) 1972-09-05 1973-08-01 N-(5(4)-imidazolyl-(alkyl,alkylthioalkyl or alkylaminoalkyl)) guanidine derivatives their preparation and pharmaceutical compositions containing them
CA177,944A CA1053242A (en) 1972-09-05 1973-08-01 Heterocyclic guanidine derivatives
AU58906/73A AU473158B2 (en) 1972-09-05 1973-08-03 Pharmacologically active compounds
NL7310836A NL7310836A (https=) 1972-09-05 1973-08-06
IE1467/73A IE38123B1 (en) 1972-09-05 1973-08-22 Heterocyclic substituted guanidines
BE135044A BE804145A (fr) 1972-09-05 1973-08-29 Guanidines, leur procede de preparation et leur application
HUSI1341A HU166637B (https=) 1972-09-05 1973-09-04
FR7331884A FR2199466B2 (https=) 1972-09-05 1973-09-04
JP10012673A JPS5732062B2 (https=) 1972-09-05 1973-09-05
DE2344833A DE2344833C2 (de) 1972-09-05 1973-09-05 5-Methylimidazol-4-ylmethylthioäthylguanidine und ihre Verwendung als Histamin-H ↓2↓-Receptor-Antagonisten
US05/558,532 US3971786A (en) 1972-09-05 1975-03-14 Pyridyl alkylguanidine compounds, composition therewith, and methods of inhibiting H-2 histamine receptors
US05/560,909 US4000296A (en) 1972-09-05 1975-03-21 Imidazole alkylguanidine compounds
US05/673,516 US4060621A (en) 1972-09-05 1976-04-05 Pyridyl alkylguanidine compounds
US05/726,356 US4083988A (en) 1972-09-05 1976-09-24 Pharmacologically active compounds
US05/726,331 US4072748A (en) 1972-09-05 1976-09-24 Certain guanidine compounds, and their use as inhibitors of histamine activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4116172A GB1398426A (en) 1972-09-05 1972-09-05 Heterocyclic substituted guanidines

Publications (1)

Publication Number Publication Date
GB1398426A true GB1398426A (en) 1975-06-18

Family

ID=10418396

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4116172A Expired GB1398426A (en) 1972-09-05 1972-09-05 Heterocyclic substituted guanidines

Country Status (11)

Country Link
JP (1) JPS5732062B2 (https=)
AU (1) AU473158B2 (https=)
BE (1) BE804145A (https=)
CA (1) CA1053242A (https=)
DE (1) DE2344833C2 (https=)
FR (1) FR2199466B2 (https=)
GB (1) GB1398426A (https=)
HU (1) HU166637B (https=)
IE (1) IE38123B1 (https=)
IL (1) IL42879A (https=)
NL (1) NL7310836A (https=)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028379A (en) * 1975-05-15 1977-06-07 Smith Kline & French Laboratories Limited Process for preparing 2-amino-2-alkylthio-1-nitroethylene compounds
US4165377A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidino imidazoles and thiazoles
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
US4242350A (en) 1978-05-24 1980-12-30 Imperial Chemical Industries Limited Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them
EP0050407A1 (en) * 1980-08-27 1982-04-28 Glaxo Group Limited 3,5-Disubstituted-1,2,4-triazole compounds, processes for their preparation and pharmaceutical compositions containing them
US4342765A (en) 1979-01-18 1982-08-03 Imperial Chemical Industries Limited Guanidine derivatives and pharmaceutical compositions containing them
US4379158A (en) 1977-08-29 1983-04-05 Yamanouchi Pharmaceutical Co., Ltd. Antisecretory imidazole amidine compounds, composition and method of use
US4514413A (en) * 1982-04-10 1985-04-30 Basf Aktiengesellschaft Gastric acid secretion inhibiting N-(imidazol-1-ylalkyl)thiourea derivatives
EP0169969A3 (en) * 1984-07-27 1987-02-04 Hoechst Uk Limited Sulphamoylguanidine derivatives

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2817078C2 (de) * 1977-04-20 1995-06-14 Zeneca Ltd Guanidinderivate
JPS5610175A (en) * 1979-07-06 1981-02-02 Fujisawa Pharmaceut Co Ltd Preparation of imidazole derivative
DE3108753A1 (de) * 1981-03-07 1982-09-16 Degussa Ag, 6000 Frankfurt Neue substituierte alkyl-phenylsulfonylguanidine miteinem heterocyclischen rest
PT77623B (en) * 1982-11-25 1986-03-19 Smith Kline French Lab Process for the preparation of a small class of histamine h2-antagonists
NL8303965A (nl) * 1982-12-08 1984-07-02 Degussa Nieuwe etheendiamine- en guanidine-derivaten; werkwijze voor het bereiden daarvan; geneesmiddelen die ze bevatten; werkwijze voor het bereiden van dergelijke geneesmiddelen; toepassing van de verbindingen voor het bereiden van geneesmiddelen en in de geneeskunde.
KR100935925B1 (ko) * 2003-05-28 2010-01-11 엘지전자 주식회사 세탁기의 캐패시터 홀더
JP6006634B2 (ja) * 2011-12-28 2016-10-12 東和薬品株式会社 イソウレア化合物を用いるエピナスチンの製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
IE36050B1 (en) * 1971-03-09 1976-08-04 Smith Kline French Lab Ureas thioureas and guanidines

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028379A (en) * 1975-05-15 1977-06-07 Smith Kline & French Laboratories Limited Process for preparing 2-amino-2-alkylthio-1-nitroethylene compounds
US4165377A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidino imidazoles and thiazoles
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
US4234735A (en) 1977-04-20 1980-11-18 Imperial Chemical Industries Limited Guanidino imidazoles and thiazoles
US4262126A (en) 1977-04-20 1981-04-14 Imperial Chemical Industries Limited Guanidine derivatives of imidazoles and thiazoles
US4379158A (en) 1977-08-29 1983-04-05 Yamanouchi Pharmaceutical Co., Ltd. Antisecretory imidazole amidine compounds, composition and method of use
US4242350A (en) 1978-05-24 1980-12-30 Imperial Chemical Industries Limited Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4342765A (en) 1979-01-18 1982-08-03 Imperial Chemical Industries Limited Guanidine derivatives and pharmaceutical compositions containing them
EP0050407A1 (en) * 1980-08-27 1982-04-28 Glaxo Group Limited 3,5-Disubstituted-1,2,4-triazole compounds, processes for their preparation and pharmaceutical compositions containing them
US4514413A (en) * 1982-04-10 1985-04-30 Basf Aktiengesellschaft Gastric acid secretion inhibiting N-(imidazol-1-ylalkyl)thiourea derivatives
EP0169969A3 (en) * 1984-07-27 1987-02-04 Hoechst Uk Limited Sulphamoylguanidine derivatives

Also Published As

Publication number Publication date
IL42879A0 (en) 1973-11-28
FR2199466A2 (https=) 1974-04-12
BE804145A (fr) 1974-02-28
NL7310836A (https=) 1974-03-07
FR2199466B2 (https=) 1977-01-28
JPS5732062B2 (https=) 1982-07-08
HU166637B (https=) 1975-04-28
IE38123L (en) 1974-03-05
JPS4975575A (https=) 1974-07-20
AU5890673A (en) 1975-02-06
DE2344833C2 (de) 1981-10-29
AU473158B2 (en) 1976-06-17
IL42879A (en) 1976-10-31
CA1053242A (en) 1979-04-24
DE2344833A1 (de) 1974-03-14
IE38123B1 (en) 1978-01-04

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977