IL42879A - N-(5(4)-imidazolyl-(alkyl,alkylthioalkyl or alkylaminoalkyl)) guanidine derivatives their preparation and pharmaceutical compositions containing them - Google Patents
N-(5(4)-imidazolyl-(alkyl,alkylthioalkyl or alkylaminoalkyl)) guanidine derivatives their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL42879A IL42879A IL42879A IL4287973A IL42879A IL 42879 A IL42879 A IL 42879A IL 42879 A IL42879 A IL 42879A IL 4287973 A IL4287973 A IL 4287973A IL 42879 A IL42879 A IL 42879A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- lower alkyl
- compound according
- compound
- sulphur
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
- C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (5)
1. A compound of the formula: N- R2 H - \ NHR-j wherein Rj 1s hydrogen or lower alkyl; Rg 1s a grouping of tbe formula Het - (CH2)mZ (CH2)n-) wherein Het 1s Imldazolyl which 1s optionally substituted by lower alkyl; Z 1s sulphur, NH or a methylene group, m and n are Integers from 0 to 4 such that their sum 1s from 2 to 4; X Is C0R3, CSR3, S02R4, N-CHRg or when Z 1s methylene, nltro; R3 1s lower alkyl, lower alkoxy, or amino; R^ 1s lower underlined alkyf ieny^fmopt ofeffyasu6st1tuted by halogen, lower alkyl, or 1.8.1973 amlnn jtPlfliinnnmPthyl ni- nminet; and Rg 1s phenyl .
2. A compound according to claim 1 wherein X 1s C0R3, SOgR^ or, when Z 1s methylene, nltro, R3 1s lower alkyl, lower alkoxy or amino; and R^ 1s lower alkyl, trlfluoromethyl , phenyl or amino.
3. A compound according to claim 1 or claim 2 wherein Rj 1s methyl .
4. A compound according to any of claims 1 to 3 wherein Z 1s sulphur, m 1s 1 and n 1s 2.
5. A compound according to any one of the preceeding claims wherein X is phenylsulphonyl, aminosulphonyl or aminocarbonyl. o 6, A compound according to claim 1 as hereinbefore described in any one of the Examples. 7 A process for the production of a compound according to claim 1 wherein an amine of the formula R2 H2 wherein R^ has the same significance as in the formula set out in claim 1 is reacted with a compound of the formula N-X A - Y - \ NHR1 wherein ^ and X have the same significance as in the formula set out in claim 1; Y is sulphur or oxygen; and A is lower alkyl. 8, A procesK according to claim 7 as hereinbefore described in any one of Examples 1 to 4, l^, 15 and l8. , A process for the production of a compound according to claim 1 wherein an amine of the formula wherein R^ has the same significance as in the formula set out in claim 1 is first reacted with a compound of the formula (A-Y)2C=M - X wherein X has the same significance as in the fotimula set out in 42879/2 claim 1; Y is sulphur or oxygen; and A is lower alkyl to give an intermediate compound of the formula Y - A and then said intermediate is reacted with an amine of the formula R-J!!L, wherein is hydrogen or lower alkyl. TO* A process according to claim ^ as hereinbefore described in 10 «- /-any one of Examples 5 to 9 -and TZ, ^ · Λ pharmaceutical composition comprising a compound according to any of claims 1 to 6 and a non-toxic pharmaceutically acceptable diluent or carrier. Attorneys for A p p l i c a n t
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4116172A GB1398426A (en) | 1972-09-05 | 1972-09-05 | Heterocyclic substituted guanidines |
Publications (2)
Publication Number | Publication Date |
---|---|
IL42879A0 IL42879A0 (en) | 1973-11-28 |
IL42879A true IL42879A (en) | 1976-10-31 |
Family
ID=10418396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL42879A IL42879A (en) | 1972-09-05 | 1973-08-01 | N-(5(4)-imidazolyl-(alkyl,alkylthioalkyl or alkylaminoalkyl)) guanidine derivatives their preparation and pharmaceutical compositions containing them |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS5732062B2 (en) |
AU (1) | AU473158B2 (en) |
BE (1) | BE804145A (en) |
CA (1) | CA1053242A (en) |
DE (1) | DE2344833C2 (en) |
FR (1) | FR2199466B2 (en) |
GB (1) | GB1398426A (en) |
HU (1) | HU166637B (en) |
IE (1) | IE38123B1 (en) |
IL (1) | IL42879A (en) |
NL (1) | NL7310836A (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1554153A (en) * | 1975-05-15 | 1979-10-17 | Smith Kline French Lab | Process for making 2-amino-2-alkylthionitroethylenes |
GR62452B (en) | 1977-04-20 | 1979-04-12 | Ici Ltd | Preparation process of guanidine derivatives |
DE2817078C2 (en) * | 1977-04-20 | 1995-06-14 | Zeneca Ltd | Guanidine derivatives |
US4165378A (en) | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
DE2835695A1 (en) | 1977-08-29 | 1979-03-15 | Yamanouchi Pharma Co Ltd | NEW HETEROCYCLIC COMPOUNDS, METHODS OF MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM |
DE2963363D1 (en) | 1978-05-24 | 1982-09-09 | Ici Plc | Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them |
JPS5610175A (en) * | 1979-07-06 | 1981-02-02 | Fujisawa Pharmaceut Co Ltd | Preparation of imidazole derivative |
EP0050407A1 (en) * | 1980-08-27 | 1982-04-28 | Glaxo Group Limited | 3,5-Disubstituted-1,2,4-triazole compounds, processes for their preparation and pharmaceutical compositions containing them |
DE3108753A1 (en) * | 1981-03-07 | 1982-09-16 | Degussa Ag, 6000 Frankfurt | Substituted alkylphenylsulphonylguanidines with a heterocyclic radical |
DE3213509A1 (en) * | 1982-04-10 | 1983-10-20 | Basf Ag, 6700 Ludwigshafen | N-SUBSTITUTED IMIDAZOLE DERIVATIVES, THEIR PRODUCTION, THE MEDICINES CONTAINING THEM AND THEIR USE |
PT77623B (en) * | 1982-11-25 | 1986-03-19 | Smith Kline French Lab | Process for the preparation of a small class of histamine h2-antagonists |
NL8303965A (en) * | 1982-12-08 | 1984-07-02 | Degussa | NEW FOOD DIAMINE AND GUANIDINE DERIVATIVES; METHOD FOR PREPARING THEREOF MEDICINES CONTAINING THEM; METHOD FOR PREPARING SUCH MEDICINES; APPLICATION OF THE COMPOUNDS FOR THE PREPARATION OF MEDICINAL PRODUCTS AND IN MEDICINE. |
GB8419223D0 (en) * | 1984-07-27 | 1984-08-30 | Hoechst Uk Ltd | Sulphamoylguanidine derivatives |
KR100935925B1 (en) * | 2003-05-28 | 2010-01-11 | 엘지전자 주식회사 | Capacitor holder of washer |
JP6006634B2 (en) * | 2011-12-28 | 2016-10-12 | 東和薬品株式会社 | Method for producing epinastine using isourea compound |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE758146A (en) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | AMIDINE DERIVATIVES |
IE36050B1 (en) * | 1971-03-09 | 1976-08-04 | Smith Kline French Lab | Ureas thioureas and guanidines |
-
1972
- 1972-09-05 GB GB4116172A patent/GB1398426A/en not_active Expired
-
1973
- 1973-08-01 CA CA177,944A patent/CA1053242A/en not_active Expired
- 1973-08-01 IL IL42879A patent/IL42879A/en unknown
- 1973-08-03 AU AU58906/73A patent/AU473158B2/en not_active Expired
- 1973-08-06 NL NL7310836A patent/NL7310836A/xx unknown
- 1973-08-22 IE IE1467/73A patent/IE38123B1/en unknown
- 1973-08-29 BE BE135044A patent/BE804145A/en not_active IP Right Cessation
- 1973-09-04 HU HUSI1341A patent/HU166637B/hu unknown
- 1973-09-04 FR FR7331884A patent/FR2199466B2/fr not_active Expired
- 1973-09-05 JP JP10012673A patent/JPS5732062B2/ja not_active Expired
- 1973-09-05 DE DE2344833A patent/DE2344833C2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BE804145A (en) | 1974-02-28 |
DE2344833C2 (en) | 1981-10-29 |
FR2199466A2 (en) | 1974-04-12 |
IE38123B1 (en) | 1978-01-04 |
IE38123L (en) | 1974-03-05 |
FR2199466B2 (en) | 1977-01-28 |
AU473158B2 (en) | 1976-06-17 |
AU5890673A (en) | 1975-02-06 |
JPS4975575A (en) | 1974-07-20 |
JPS5732062B2 (en) | 1982-07-08 |
CA1053242A (en) | 1979-04-24 |
NL7310836A (en) | 1974-03-07 |
DE2344833A1 (en) | 1974-03-14 |
GB1398426A (en) | 1975-06-18 |
HU166637B (en) | 1975-04-28 |
IL42879A0 (en) | 1973-11-28 |
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