GB1397234A - N,n-disubstituted thioureas their preparation and their use as antimicrobial substances - Google Patents
N,n-disubstituted thioureas their preparation and their use as antimicrobial substancesInfo
- Publication number
- GB1397234A GB1397234A GB350974A GB350974A GB1397234A GB 1397234 A GB1397234 A GB 1397234A GB 350974 A GB350974 A GB 350974A GB 350974 A GB350974 A GB 350974A GB 1397234 A GB1397234 A GB 1397234A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- general formula
- antimicrobial substances
- disubstituted thioureas
- jan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003585 thioureas Chemical class 0.000 title abstract 3
- 230000000845 anti-microbial effect Effects 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical class NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- ZOJBYZNEUISWFT-UHFFFAOYSA-N allyl isothiocyanate Chemical class C=CCN=C=S ZOJBYZNEUISWFT-UHFFFAOYSA-N 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
- C07C335/26—Y being a hydrogen or a carbon atom, e.g. benzoylthioureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2303761A DE2303761A1 (de) | 1973-01-26 | 1973-01-26 | Neue n,n'-disubstituierte thioharnstoffe, deren herstellung sowie verwendung als antimikrobielle substanzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1397234A true GB1397234A (en) | 1975-06-11 |
Family
ID=5870017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB350974A Expired GB1397234A (en) | 1973-01-26 | 1974-01-25 | N,n-disubstituted thioureas their preparation and their use as antimicrobial substances |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3966968A (cg-RX-API-DMAC7.html) |
| BE (1) | BE810147A (cg-RX-API-DMAC7.html) |
| DE (1) | DE2303761A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2215228B1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1397234A (cg-RX-API-DMAC7.html) |
| IT (1) | IT1053752B (cg-RX-API-DMAC7.html) |
| NL (1) | NL7317791A (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0915651A4 (en) * | 1996-06-27 | 2001-10-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| EP0912505A4 (en) * | 1996-06-27 | 2001-10-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2450073C (en) | 2001-07-25 | 2017-08-29 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| AR041834A1 (es) * | 2002-10-29 | 2005-06-01 | Smithkline Beecham Corp | Compuesto de difenilurea sustituido con sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion |
| CN1738797A (zh) | 2002-11-19 | 2006-02-22 | 阿基里昂药品公司 | 取代的芳基硫脲和相关的化合物,病毒复制的抑制剂 |
| TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| MX2008013600A (es) * | 2006-04-21 | 2008-10-31 | Smithkline Beechman Corp | Antagonistas del receptor de interleuquina-8. |
| CA2650007A1 (en) * | 2006-04-21 | 2007-11-01 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| CL2007001829A1 (es) * | 2006-06-23 | 2008-01-25 | Smithkline Beecham Corp | P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc. |
| JP2010503710A (ja) | 2006-09-18 | 2010-02-04 | ラプトール ファーマシューティカル インコーポレイテッド | 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置 |
| DE102008047743A1 (de) * | 2008-09-17 | 2010-04-15 | Henkel Ag & Co. Kgaa | Verwendung von Harnstoff-Derivaten und Phenacylthiazolium-Salzen zur Behandlung von Körpergeruch |
| US8028844B2 (en) * | 2008-11-20 | 2011-10-04 | Costa Charles A | Sliding closet rack |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| DE102009029370A1 (de) | 2009-09-11 | 2011-03-24 | Henkel Ag & Co. Kgaa | Inhibierung von Körpergerüchen |
| US8628961B2 (en) | 2010-05-18 | 2014-01-14 | Tufts University | Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL193403A (cg-RX-API-DMAC7.html) * | 1953-12-22 | 1924-02-17 | ||
| US3686418A (en) * | 1969-10-23 | 1972-08-22 | Armour & Co | N-acyl-n{40 -(halogenated aryl ureas as antibacterial agents) |
| SU517587A1 (ru) * | 1971-08-23 | 1976-06-15 | Медицинска Академие (Инопредприятие) | Способ получени производных 2оксфенилмочевины |
-
1973
- 1973-01-26 DE DE2303761A patent/DE2303761A1/de active Pending
- 1973-12-18 US US05/425,800 patent/US3966968A/en not_active Expired - Lifetime
- 1973-12-28 NL NL7317791A patent/NL7317791A/xx unknown
-
1974
- 1974-01-21 IT IT19644/74A patent/IT1053752B/it active
- 1974-01-25 FR FR7402599A patent/FR2215228B1/fr not_active Expired
- 1974-01-25 GB GB350974A patent/GB1397234A/en not_active Expired
- 1974-01-25 BE BE140163A patent/BE810147A/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0915651A4 (en) * | 1996-06-27 | 2001-10-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| EP0912505A4 (en) * | 1996-06-27 | 2001-10-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1053752B (it) | 1981-10-10 |
| US3966968A (en) | 1976-06-29 |
| DE2303761A1 (de) | 1974-08-01 |
| BE810147A (fr) | 1974-07-25 |
| FR2215228B1 (cg-RX-API-DMAC7.html) | 1977-09-09 |
| FR2215228A1 (cg-RX-API-DMAC7.html) | 1974-08-23 |
| NL7317791A (cg-RX-API-DMAC7.html) | 1974-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |