GB1397035A - Process for the manufacture of isomorphinans - Google Patents
Process for the manufacture of isomorphinansInfo
- Publication number
- GB1397035A GB1397035A GB3221073A GB3221073A GB1397035A GB 1397035 A GB1397035 A GB 1397035A GB 3221073 A GB3221073 A GB 3221073A GB 3221073 A GB3221073 A GB 3221073A GB 1397035 A GB1397035 A GB 1397035A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- proton
- alkanoyl
- carbamoyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-O oxonium Chemical compound [OH3+] XLYOFNOQVPJJNP-UHFFFAOYSA-O 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- QYXMTRMBTVDSOQ-UHFFFAOYSA-N 1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline Chemical class N1CCC(CCCC2)=C2C1CC1=CC=CC=C1 QYXMTRMBTVDSOQ-UHFFFAOYSA-N 0.000 abstract 1
- ZNBXUIHEGUGLBC-UHFFFAOYSA-N 1-benzyl-2,3,4,5,6,7,8,8a-octahydro-1h-isoquinolin-4a-ol Chemical compound N1CCC2(O)CCCCC2C1CC1=CC=CC=C1 ZNBXUIHEGUGLBC-UHFFFAOYSA-N 0.000 abstract 1
- 229910015900 BF3 Inorganic materials 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical group C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 1
- 125000004971 nitroalkyl group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000006678 phenoxycarbonyl group Chemical group 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1020272 | 1972-07-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1397035A true GB1397035A (en) | 1975-06-11 |
Family
ID=4360534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3221073A Expired GB1397035A (en) | 1972-07-07 | 1973-07-06 | Process for the manufacture of isomorphinans |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS4942679A (enrdf_load_stackoverflow) |
| BE (1) | BE801984A (enrdf_load_stackoverflow) |
| DE (1) | DE2327737A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2192103B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1397035A (enrdf_load_stackoverflow) |
| NL (1) | NL7308437A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2631145C2 (de) * | 1976-07-10 | 1981-09-24 | Bayer Ag, 5090 Leverkusen | Verfahren und Vorrichtung zum Auftragen einer Schicht eines flüssigen, schäumfähigen Reaktionsgemisches auf eine kontinuierlich geförderte Unterlage |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH560194A5 (enrdf_load_stackoverflow) * | 1967-08-25 | 1975-03-27 | Hoffmann La Roche |
-
1973
- 1973-05-30 DE DE19732327737 patent/DE2327737A1/de active Pending
- 1973-06-18 NL NL7308437A patent/NL7308437A/xx unknown
- 1973-07-04 FR FR7324551A patent/FR2192103B1/fr not_active Expired
- 1973-07-06 BE BE133173A patent/BE801984A/xx unknown
- 1973-07-06 JP JP7586173A patent/JPS4942679A/ja active Pending
- 1973-07-06 GB GB3221073A patent/GB1397035A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4942679A (enrdf_load_stackoverflow) | 1974-04-22 |
| FR2192103B1 (enrdf_load_stackoverflow) | 1976-05-07 |
| BE801984A (fr) | 1974-01-07 |
| FR2192103A1 (enrdf_load_stackoverflow) | 1974-02-08 |
| DE2327737A1 (de) | 1974-01-24 |
| NL7308437A (enrdf_load_stackoverflow) | 1974-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |