GB1388580A - Hydrogels - Google Patents
HydrogelsInfo
- Publication number
- GB1388580A GB1388580A GB6009472A GB6009472A GB1388580A GB 1388580 A GB1388580 A GB 1388580A GB 6009472 A GB6009472 A GB 6009472A GB 6009472 A GB6009472 A GB 6009472A GB 1388580 A GB1388580 A GB 1388580A
- Authority
- GB
- United Kingdom
- Prior art keywords
- metal ion
- sustained release
- polyvalent metal
- insulin
- mol per
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000017 hydrogel Substances 0.000 title abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 3
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 238000013268 sustained release Methods 0.000 abstract 2
- 239000012730 sustained-release form Substances 0.000 abstract 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract 1
- 230000009920 chelation Effects 0.000 abstract 1
- 229960003067 cystine Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000002504 physiological saline solution Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
- C08L77/04—Polyamides derived from alpha-amino carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
- C08B15/10—Crosslinking of cellulose
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/003—Crosslinking of starch
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B33/00—Preparation of derivatives of amylose
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP479572A JPS5416979B2 (enrdf_load_stackoverflow) | 1972-01-08 | 1972-01-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1388580A true GB1388580A (en) | 1975-03-26 |
Family
ID=11593698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6009472A Expired GB1388580A (en) | 1972-01-08 | 1972-12-29 | Hydrogels |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS5416979B2 (enrdf_load_stackoverflow) |
| GB (1) | GB1388580A (enrdf_load_stackoverflow) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2332863A1 (fr) * | 1975-07-15 | 1977-06-24 | Massachusetts Inst Technology | Membrane multi-couches utile comme peau synthetique |
| US4164560A (en) | 1977-01-05 | 1979-08-14 | Folkman Moses J | Systems for the controlled release of macromolecules |
| US4217417A (en) | 1977-04-29 | 1980-08-12 | Diamond Shamrock (Polymers) Limited | Resin chelates |
| US4372328A (en) | 1980-05-20 | 1983-02-08 | B.A.T. Cigaretten-Fabriken Gmbh | Fibrous material for tobacco smoke filter |
| US4391797A (en) | 1977-01-05 | 1983-07-05 | The Children's Hospital Medical Center | Systems for the controlled release of macromolecules |
| US4526938A (en) * | 1982-04-22 | 1985-07-02 | Imperial Chemical Industries Plc | Continuous release formulations |
| FR2665374A1 (fr) * | 1990-08-03 | 1992-02-07 | Bioetica Sa | Microcapsules a paroi mixte d'atelocollagene et de polyholosides coagulee par un cation bivalent et procede de fabrication de ces microcapsules et des compositions cosmetiques ou pharmaceutiques ou alimentaires en contenant. |
| US6656508B2 (en) | 1997-04-17 | 2003-12-02 | Amgen Inc. | Sustained-release alginate gels |
| BG64860B1 (bg) * | 1997-05-16 | 2006-07-31 | Amgen Inc. | Фармацевтичен състав с продължително освобождаване и неговото използване |
| AU2005200949B2 (en) * | 1997-05-16 | 2007-09-20 | Amgen Inc. | Sustained-Release Delayed Gels |
| JP2008120838A (ja) * | 2008-02-21 | 2008-05-29 | Medgel Corp | 配位結合を利用した薬物−高分子複合体製剤の調製方法 |
| BG65397B1 (bg) * | 1998-05-18 | 2008-06-30 | Amgen Inc. | Биоразпадащ се алгинатен гел с постоянно отделяне |
| CN113248742A (zh) * | 2021-06-15 | 2021-08-13 | 西华大学 | 一种pH和光双重响应天然多糖水凝胶及其制备方法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58162595A (ja) * | 1982-03-19 | 1983-09-27 | Green Cross Corp:The | 徐放性アルブミン複合体の製法 |
| US6610810B2 (en) * | 2001-03-13 | 2003-08-26 | Glyn Owen Phillips | Biopolymers obtained by solid state irradiation in an unsaturated gaseous atmosphere |
-
1972
- 1972-01-08 JP JP479572A patent/JPS5416979B2/ja not_active Expired
- 1972-12-29 GB GB6009472A patent/GB1388580A/en not_active Expired
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2332863A1 (fr) * | 1975-07-15 | 1977-06-24 | Massachusetts Inst Technology | Membrane multi-couches utile comme peau synthetique |
| US4164560A (en) | 1977-01-05 | 1979-08-14 | Folkman Moses J | Systems for the controlled release of macromolecules |
| US4391797A (en) | 1977-01-05 | 1983-07-05 | The Children's Hospital Medical Center | Systems for the controlled release of macromolecules |
| US4217417A (en) | 1977-04-29 | 1980-08-12 | Diamond Shamrock (Polymers) Limited | Resin chelates |
| US4372328A (en) | 1980-05-20 | 1983-02-08 | B.A.T. Cigaretten-Fabriken Gmbh | Fibrous material for tobacco smoke filter |
| US4526938A (en) * | 1982-04-22 | 1985-07-02 | Imperial Chemical Industries Plc | Continuous release formulations |
| US5525359A (en) * | 1990-08-03 | 1996-06-11 | Coletica | Microcapsules having a combined atelocollagen/polyholoside wall coagulated by a divalent cation and method for manufacturing these microcapsules and cosmetic or pharmaceutical or food compositions containing them |
| WO1992002254A1 (fr) * | 1990-08-03 | 1992-02-20 | Coletica | Microcapsules a paroi mixte d'atelocollagene et de polyholosides coagulee par un cation bivalent |
| FR2665374A1 (fr) * | 1990-08-03 | 1992-02-07 | Bioetica Sa | Microcapsules a paroi mixte d'atelocollagene et de polyholosides coagulee par un cation bivalent et procede de fabrication de ces microcapsules et des compositions cosmetiques ou pharmaceutiques ou alimentaires en contenant. |
| US6656508B2 (en) | 1997-04-17 | 2003-12-02 | Amgen Inc. | Sustained-release alginate gels |
| BG64860B1 (bg) * | 1997-05-16 | 2006-07-31 | Amgen Inc. | Фармацевтичен състав с продължително освобождаване и неговото използване |
| AU2005200949B2 (en) * | 1997-05-16 | 2007-09-20 | Amgen Inc. | Sustained-Release Delayed Gels |
| BG65397B1 (bg) * | 1998-05-18 | 2008-06-30 | Amgen Inc. | Биоразпадащ се алгинатен гел с постоянно отделяне |
| JP2008120838A (ja) * | 2008-02-21 | 2008-05-29 | Medgel Corp | 配位結合を利用した薬物−高分子複合体製剤の調製方法 |
| CN113248742A (zh) * | 2021-06-15 | 2021-08-13 | 西华大学 | 一种pH和光双重响应天然多糖水凝胶及其制备方法 |
| CN113248742B (zh) * | 2021-06-15 | 2023-05-05 | 西华大学 | 一种pH和光双重响应天然多糖水凝胶及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4874549A (enrdf_load_stackoverflow) | 1973-10-08 |
| JPS5416979B2 (enrdf_load_stackoverflow) | 1979-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |