GB1386656A - Adenosine-5-carboxylic acid amides - Google Patents

Adenosine-5-carboxylic acid amides

Info

Publication number
GB1386656A
GB1386656A GB844672A GB844672A GB1386656A GB 1386656 A GB1386656 A GB 1386656A GB 844672 A GB844672 A GB 844672A GB 844672 A GB844672 A GB 844672A GB 1386656 A GB1386656 A GB 1386656A
Authority
GB
United Kingdom
Prior art keywords
adenosine
carboxylic acid
compounds
acid amides
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB844672A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of GB1386656A publication Critical patent/GB1386656A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Abstract

1386656 Adenosine-5<SP>1</SP>-carboxylic acid amides ABBOT LABORATORIES 23 Feb 1972 [18 March 1971] 8446/72 Heading C2C Novel compounds of general Formula I in which R is NHR 1 or NR 1 R 2 and R 1 and R 2 are selected from C 1-6 haloalkyl, C 3-6 hydroxyalkyl (C 3-7 cycloalkyl) C 1-6 alkyl, C 2-6 haloalkenyl, C 2-6 alkynyl, C 2-6 haloalkynyl or alkoxyalkyl with up to 6 C atoms are prepared by converting adenosine-5<SP>1</SP>-carboxylic acid (prepared from 2<SP>1</SP>,3<SP>1</SP>-isopropylidene adenosine) to the corresponding acid chloride by using thionyl chloride and reacting the acid chloride with ammonia or an appropriately substituted alkylamine. Compounds referred to are those in which the amide group is N-cyclopropylmethyl amido, N-propargylamido, N-ethoxyethylamido, N,N-dicyclopropylmethylamide and N,N-di-chloromethylamido. Compounds of Formula I are anti-hypertensive and anti-anginal agents and form with a carrier a pharmaceutical composition which may be administered orally or parenterally. Reference has been directed by the Comptroller to Specification 1,295,228.
GB844672A 1971-03-18 1972-02-23 Adenosine-5-carboxylic acid amides Expired GB1386656A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12589371A 1971-03-18 1971-03-18

Publications (1)

Publication Number Publication Date
GB1386656A true GB1386656A (en) 1975-03-12

Family

ID=22421948

Family Applications (1)

Application Number Title Priority Date Filing Date
GB844672A Expired GB1386656A (en) 1971-03-18 1972-02-23 Adenosine-5-carboxylic acid amides

Country Status (9)

Country Link
AU (1) AU466714B2 (en)
CA (1) CA1019727A (en)
CH (1) CH551446A (en)
DE (1) DE2213180A1 (en)
FR (1) FR2130364A1 (en)
GB (1) GB1386656A (en)
PH (1) PH9469A (en)
SE (1) SE405363B (en)
ZA (1) ZA721222B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495528B1 (en) 1998-06-23 2002-12-17 Smithkline Beecham Corporation 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives
US6762170B1 (en) 1998-01-31 2004-07-13 Smithklinebeecham Corporation 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
US7737126B2 (en) 2004-05-24 2010-06-15 Glaxo Group Limited Purine derivative
US7985740B2 (en) 2005-07-19 2011-07-26 Glaxo Group Limited Purine derivatives as agonists of the adenosine A2A receptor

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI880405A (en) * 1987-02-04 1988-08-05 Ciba Geigy Ag Adenosine-5'-KARBOXAMIDDERIVAT.
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
PT1492511E (en) 2002-04-09 2009-04-09 Flamel Tech Sa Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s)
WO2003084517A2 (en) 2002-04-09 2003-10-16 Flamel Technologies Oral suspension of amoxicillin capsules

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762170B1 (en) 1998-01-31 2004-07-13 Smithklinebeecham Corporation 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
US6495528B1 (en) 1998-06-23 2002-12-17 Smithkline Beecham Corporation 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives
US7737126B2 (en) 2004-05-24 2010-06-15 Glaxo Group Limited Purine derivative
US7985740B2 (en) 2005-07-19 2011-07-26 Glaxo Group Limited Purine derivatives as agonists of the adenosine A2A receptor

Also Published As

Publication number Publication date
AU3934672A (en) 1973-08-30
FR2130364A1 (en) 1972-11-03
PH9469A (en) 1975-12-16
AU466714B2 (en) 1973-08-30
DE2213180A1 (en) 1972-09-28
SE405363B (en) 1978-12-04
ZA721222B (en) 1972-11-29
CA1019727A (en) 1977-10-25
CH551446A (en) 1974-07-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee