GB1384518A - Acylated n6-aralkyl-adenosine derivatives - Google Patents
Acylated n6-aralkyl-adenosine derivativesInfo
- Publication number
- GB1384518A GB1384518A GB3648973A GB3648973A GB1384518A GB 1384518 A GB1384518 A GB 1384518A GB 3648973 A GB3648973 A GB 3648973A GB 3648973 A GB3648973 A GB 3648973A GB 1384518 A GB1384518 A GB 1384518A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aralkyl
- compounds
- acylated
- aug
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 trimethylsilyloxy Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- JBFYUZGYRGXSFL-UHFFFAOYSA-N imidazolide Chemical compound C1=C[N-]C=N1 JBFYUZGYRGXSFL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2238923A DE2238923A1 (de) | 1972-08-08 | 1972-08-08 | Acylierte n(6)-aralkyl-adenosinderivate und verfahren zur herstellung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1384518A true GB1384518A (en) | 1975-02-19 |
Family
ID=5852971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3648973A Expired GB1384518A (en) | 1972-08-08 | 1973-08-01 | Acylated n6-aralkyl-adenosine derivatives |
Country Status (12)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5519950A (en) * | 1978-07-29 | 1980-02-13 | Katsukio Akiyama | Power generator using cooling gas |
| US4214170A (en) * | 1978-10-12 | 1980-07-22 | Carrier Corporation | Power generation-refrigeration system |
| EP0180614B1 (en) * | 1984-04-18 | 1990-03-07 | Whitby Research Incorporated | N-6 substituted adenosine derivatives as cardiac vasodilators |
| WO1988003147A1 (en) * | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
| US5066655A (en) * | 1987-04-24 | 1991-11-19 | Whitby Research, Inc. | N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists |
| US5565566A (en) * | 1987-04-24 | 1996-10-15 | Discovery Therapeutics, Inc. | N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists |
-
1972
- 1972-08-08 DE DE2238923A patent/DE2238923A1/de active Pending
-
1973
- 1973-07-31 CA CA177,826A patent/CA1003411A/en not_active Expired
- 1973-08-01 ES ES417471A patent/ES417471A1/es not_active Expired
- 1973-08-01 GB GB3648973A patent/GB1384518A/en not_active Expired
- 1973-08-02 AU AU58857/73A patent/AU470398B2/en not_active Expired
- 1973-08-03 CH CH1130773A patent/CH579587A5/xx not_active IP Right Cessation
- 1973-08-06 ZA ZA735331A patent/ZA735331B/xx unknown
- 1973-08-06 FR FR7328648A patent/FR2195434B1/fr not_active Expired
- 1973-08-07 SE SE7310808A patent/SE400086B/xx unknown
- 1973-08-07 NL NL7310870A patent/NL7310870A/xx not_active Application Discontinuation
- 1973-08-07 AT AT691873A patent/AT325784B/de active
- 1973-08-08 JP JP48089161A patent/JPS4945095A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU470398B2 (en) | 1976-03-11 |
| ES417471A1 (es) | 1976-03-01 |
| AT325784B (de) | 1975-11-10 |
| SE400086B (sv) | 1978-03-13 |
| ATA691873A (de) | 1975-01-15 |
| CA1003411A (en) | 1977-01-11 |
| AU5885773A (en) | 1975-02-06 |
| JPS4945095A (enrdf_load_stackoverflow) | 1974-04-27 |
| CH579587A5 (enrdf_load_stackoverflow) | 1976-09-15 |
| ZA735331B (en) | 1974-08-28 |
| FR2195434B1 (enrdf_load_stackoverflow) | 1977-02-25 |
| DE2238923A1 (de) | 1974-02-14 |
| FR2195434A1 (enrdf_load_stackoverflow) | 1974-03-08 |
| NL7310870A (enrdf_load_stackoverflow) | 1974-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |