GB1384518A - Acylated n6-aralkyl-adenosine derivatives - Google Patents
Acylated n6-aralkyl-adenosine derivativesInfo
- Publication number
- GB1384518A GB1384518A GB3648973A GB3648973A GB1384518A GB 1384518 A GB1384518 A GB 1384518A GB 3648973 A GB3648973 A GB 3648973A GB 3648973 A GB3648973 A GB 3648973A GB 1384518 A GB1384518 A GB 1384518A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aralkyl
- compounds
- acylated
- aug
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
1384518 Acylated-N<SP>6</SP>-aralkyl-adenosine derivatives BOEHRINGER MANNHEIM GmbH 1 Aug 1973 [8 Aug 1972] 36489/73 Heading C2C Novel compounds I in which R 1 , R 2 and R 3 are hydrogen, halogen, alkyl, alkoxy or alkylthio and at least one is not hydrogen and R 4 is alkyl, aralkyl or heterocyclic and salts thereof are prepared by (1) acylation of a compound II with an acid R 4 COOH or a halide, anhydride, azide, imidazolide or reactive ester thereof or (2) reaction of a compound IV in which X is halogen, trimethylsilyloxy or a reactive mercapto group with an R 1 ,R 2 ,R 3 -substituted-benzylamine. Compounds I prepared are those in which R 4 CO is nicotinoyl, benzoyl or acetyl and R 1 , R 2 and R 3 are methyl; dimethyl, trimethyl, methylthio with chloro or methoxy with chloro. Compounds I affect blood vessels and circulation and form with a diluent or carrier a pharmaceutical composition which may be administered orally or parenterally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2238923A DE2238923A1 (en) | 1972-08-08 | 1972-08-08 | ACYLATED N (6) ARALKYL ADENOSINE DERIVATIVES AND METHOD FOR PREPARING THE SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1384518A true GB1384518A (en) | 1975-02-19 |
Family
ID=5852971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3648973A Expired GB1384518A (en) | 1972-08-08 | 1973-08-01 | Acylated n6-aralkyl-adenosine derivatives |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS4945095A (en) |
AT (1) | AT325784B (en) |
AU (1) | AU470398B2 (en) |
CA (1) | CA1003411A (en) |
CH (1) | CH579587A5 (en) |
DE (1) | DE2238923A1 (en) |
ES (1) | ES417471A1 (en) |
FR (1) | FR2195434B1 (en) |
GB (1) | GB1384518A (en) |
NL (1) | NL7310870A (en) |
SE (1) | SE400086B (en) |
ZA (1) | ZA735331B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5519950A (en) * | 1978-07-29 | 1980-02-13 | Katsukio Akiyama | Power generator using cooling gas |
US4214170A (en) * | 1978-10-12 | 1980-07-22 | Carrier Corporation | Power generation-refrigeration system |
DE3576344D1 (en) * | 1984-04-18 | 1990-04-12 | Whitby Research Inc | CARDIO VASODILATATORS N-6 SUBSTITUTED ADENOSINE. |
AU8276187A (en) * | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
US5066655A (en) * | 1987-04-24 | 1991-11-19 | Whitby Research, Inc. | N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists |
US5565566A (en) * | 1987-04-24 | 1996-10-15 | Discovery Therapeutics, Inc. | N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists |
-
1972
- 1972-08-08 DE DE2238923A patent/DE2238923A1/en active Pending
-
1973
- 1973-07-31 CA CA177,826A patent/CA1003411A/en not_active Expired
- 1973-08-01 GB GB3648973A patent/GB1384518A/en not_active Expired
- 1973-08-01 ES ES417471A patent/ES417471A1/en not_active Expired
- 1973-08-02 AU AU58857/73A patent/AU470398B2/en not_active Expired
- 1973-08-03 CH CH1130773A patent/CH579587A5/xx not_active IP Right Cessation
- 1973-08-06 FR FR7328648A patent/FR2195434B1/fr not_active Expired
- 1973-08-06 ZA ZA735331A patent/ZA735331B/en unknown
- 1973-08-07 SE SE7310808A patent/SE400086B/en unknown
- 1973-08-07 AT AT691873A patent/AT325784B/en active
- 1973-08-07 NL NL7310870A patent/NL7310870A/xx not_active Application Discontinuation
- 1973-08-08 JP JP48089161A patent/JPS4945095A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATA691873A (en) | 1975-01-15 |
JPS4945095A (en) | 1974-04-27 |
NL7310870A (en) | 1974-02-12 |
DE2238923A1 (en) | 1974-02-14 |
AU5885773A (en) | 1975-02-06 |
CH579587A5 (en) | 1976-09-15 |
ES417471A1 (en) | 1976-03-01 |
FR2195434B1 (en) | 1977-02-25 |
ZA735331B (en) | 1974-08-28 |
FR2195434A1 (en) | 1974-03-08 |
AU470398B2 (en) | 1976-03-11 |
CA1003411A (en) | 1977-01-11 |
SE400086B (en) | 1978-03-13 |
AT325784B (en) | 1975-11-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |