GB1377220A - Process for the preparation of penicillins - Google Patents
Process for the preparation of penicillinsInfo
- Publication number
- GB1377220A GB1377220A GB5807771A GB5807771A GB1377220A GB 1377220 A GB1377220 A GB 1377220A GB 5807771 A GB5807771 A GB 5807771A GB 5807771 A GB5807771 A GB 5807771A GB 1377220 A GB1377220 A GB 1377220A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aryl group
- phenyl
- preparation
- substituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1377220 Preparation of α-aminobenzylpenicillins E R SQUIBB & SONS Ine 14 Dec 1971 [29 Dec 1970] 58077/71 Heading C2C A process for the preparation of an α-aminobenzylpenicillin which is optionally substituted in the phenyl moiety comprises reacting a 6- arylidene-aminopenicillanic acid of general Formula I: wherein R represents a substituted or unsubstituted aryl group, with a phenylglycine N- carboxylic acid anhydride in a substantially anhydrous organic solvent followed by reaction with an arylamine. The aryl group R (and also the aryl group of the arylamine) may be a monocyclic or bicyclic carbocyclic aryl group, such as phenyl or naphthyl, which may be substituted with alkoxy, alkyl, phenyl, halogen or nitro groups. The phenyl group of the phenylglycine-N-carboxylic anhydride may be unsubstituted or bear a hydroxy, halogen or alkoxy group. Suitable solvents include halogenated hydrocarbons and the reaction may be carried out between 0‹ and 10‹ C. Reference has been directed by the Comptroller to Specifications 978,178, 902,703 and 873,049.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12963570 | 1970-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1377220A true GB1377220A (en) | 1974-12-11 |
Family
ID=15014357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5807771A Expired GB1377220A (en) | 1970-12-29 | 1971-12-14 | Process for the preparation of penicillins |
Country Status (6)
| Country | Link |
|---|---|
| CA (1) | CA963901A (en) |
| CH (1) | CH556356A (en) |
| DE (1) | DE2163279A1 (en) |
| FR (1) | FR2121095A5 (en) |
| GB (1) | GB1377220A (en) |
| HU (1) | HU162886B (en) |
-
1971
- 1971-12-13 CA CA129,980A patent/CA963901A/en not_active Expired
- 1971-12-14 GB GB5807771A patent/GB1377220A/en not_active Expired
- 1971-12-20 HU HUSU000701 patent/HU162886B/hu unknown
- 1971-12-20 DE DE19712163279 patent/DE2163279A1/en active Pending
- 1971-12-28 CH CH1905571A patent/CH556356A/en not_active IP Right Cessation
- 1971-12-29 FR FR7147363A patent/FR2121095A5/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2163279A1 (en) | 1972-08-03 |
| FR2121095A5 (en) | 1972-08-18 |
| HU162886B (en) | 1973-04-28 |
| CA963901A (en) | 1975-03-04 |
| CH556356A (en) | 1974-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |