GB1374339A - Aminoquinoline derivatives and their production - Google Patents
Aminoquinoline derivatives and their productionInfo
- Publication number
- GB1374339A GB1374339A GB1310272A GB1310272A GB1374339A GB 1374339 A GB1374339 A GB 1374339A GB 1310272 A GB1310272 A GB 1310272A GB 1310272 A GB1310272 A GB 1310272A GB 1374339 A GB1374339 A GB 1374339A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- radical
- alkyl
- ono
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000005010 aminoquinolines Chemical class 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001351 alkyl iodides Chemical class 0.000 abstract 3
- CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- HXELGNKCCDGMMN-UHFFFAOYSA-N [F].[Cl] Chemical compound [F].[Cl] HXELGNKCCDGMMN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000003257 anti-anginal effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 methylene dioxy Chemical group 0.000 abstract 1
- 150000002823 nitrates Chemical class 0.000 abstract 1
- 230000000802 nitrating effect Effects 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12737671A | 1971-03-23 | 1971-03-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1374339A true GB1374339A (en) | 1974-11-20 |
Family
ID=22429789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1310272A Expired GB1374339A (en) | 1971-03-23 | 1972-03-21 | Aminoquinoline derivatives and their production |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | ATA243272A (enrdf_load_stackoverflow) |
| BE (1) | BE781013A (enrdf_load_stackoverflow) |
| DD (1) | DD100253A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2214051A1 (enrdf_load_stackoverflow) |
| ES (1) | ES401024A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2130520B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1374339A (enrdf_load_stackoverflow) |
| HU (1) | HU165249B (enrdf_load_stackoverflow) |
| NL (1) | NL7203479A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0073997A1 (de) * | 1981-09-03 | 1983-03-16 | Bayer Ag | Substituierte 2-Amino-3,4-dihydropyridinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
| CN102796040A (zh) * | 2012-08-23 | 2012-11-28 | 天津药物研究院 | 1,4-二取代哌嗪衍生物、其制备方法和用途 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817520A (en) * | 1991-12-20 | 1998-10-06 | Oxis International S.A. | Spectrophotometric methods for assaying total mercaptans, reduced glutathione (GSH) and mercaptans other than GSH in an aqueous medium reagents and kits for implementing same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3637701A (en) * | 1969-03-03 | 1972-01-25 | Sandoz Ag | Certain nitrate derivatives of 4-aminoquinazolines |
-
1972
- 1972-03-16 NL NL7203479A patent/NL7203479A/xx unknown
- 1972-03-21 DD DD16169172A patent/DD100253A5/xx unknown
- 1972-03-21 BE BE781013A patent/BE781013A/xx unknown
- 1972-03-21 GB GB1310272A patent/GB1374339A/en not_active Expired
- 1972-03-21 HU HUSA002331 patent/HU165249B/hu unknown
- 1972-03-21 ES ES401024A patent/ES401024A1/es not_active Expired
- 1972-03-22 AT AT243272A patent/ATA243272A/de not_active Application Discontinuation
- 1972-03-22 FR FR7209933A patent/FR2130520B1/fr not_active Expired
- 1972-03-23 DE DE19722214051 patent/DE2214051A1/de active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0073997A1 (de) * | 1981-09-03 | 1983-03-16 | Bayer Ag | Substituierte 2-Amino-3,4-dihydropyridinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
| CN102796040A (zh) * | 2012-08-23 | 2012-11-28 | 天津药物研究院 | 1,4-二取代哌嗪衍生物、其制备方法和用途 |
| CN102796040B (zh) * | 2012-08-23 | 2015-03-25 | 天津药物研究院 | 1,4-二取代哌嗪衍生物、其制备方法和用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| BE781013A (fr) | 1972-09-21 |
| NL7203479A (enrdf_load_stackoverflow) | 1972-09-26 |
| FR2130520B1 (enrdf_load_stackoverflow) | 1975-12-26 |
| HU165249B (enrdf_load_stackoverflow) | 1974-07-27 |
| DE2214051A1 (de) | 1972-10-05 |
| FR2130520A1 (enrdf_load_stackoverflow) | 1972-11-03 |
| DD100253A5 (enrdf_load_stackoverflow) | 1973-09-12 |
| ES401024A1 (es) | 1975-09-01 |
| ATA243272A (de) | 1975-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |