GB1374283A - Benzothiazine benzoxazine and indoline derivatives - Google Patents
Benzothiazine benzoxazine and indoline derivativesInfo
- Publication number
- GB1374283A GB1374283A GB4882871A GB4882871A GB1374283A GB 1374283 A GB1374283 A GB 1374283A GB 4882871 A GB4882871 A GB 4882871A GB 4882871 A GB4882871 A GB 4882871A GB 1374283 A GB1374283 A GB 1374283A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- general formula
- benzothiazinones
- benzoxazinones
- sulphone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XXARTHUIZSKUKG-UHFFFAOYSA-N O1NC=CC2=C1C=CC=C2.S2NC=CC1=C2C=CC=C1 Chemical compound O1NC=CC2=C1C=CC=C2.S2NC=CC1=C2C=CC=C1 XXARTHUIZSKUKG-UHFFFAOYSA-N 0.000 title 1
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 title 1
- MJNPHLBKHKJDEF-UHFFFAOYSA-N 2h-1$l^{4},2-benzothiazine 1-oxide Chemical class C1=CC=C2S(=O)NC=CC2=C1 MJNPHLBKHKJDEF-UHFFFAOYSA-N 0.000 abstract 3
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical class C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 abstract 3
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 abstract 3
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical group CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- 125000001174 sulfone group Chemical group 0.000 abstract 2
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical class 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8250970A | 1970-10-20 | 1970-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1374283A true GB1374283A (en) | 1974-11-20 |
Family
ID=22171656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4882871A Expired GB1374283A (en) | 1970-10-20 | 1971-10-20 | Benzothiazine benzoxazine and indoline derivatives |
Country Status (7)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0241006A3 (en) * | 1986-04-10 | 1988-08-10 | E.I. Du Pont De Nemours And Company | 3,3-disubstituted indolines |
| EP0303180A1 (de) * | 1987-08-12 | 1989-02-15 | Hoechst Aktiengesellschaft | Benzothiazinon-oxide, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und deren Verwendung sowie Zwischenprodukte zu ihrer Herstellung |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4033951A (en) * | 1973-12-13 | 1977-07-05 | Imperial Chemical Industries Limited | Morpholine derivative of a 1,4-benzothiazin-3-one |
| US4079135A (en) * | 1973-12-13 | 1978-03-14 | Imperial Chemical Industries Limited | Morpholine derivatives as antidepressants |
| GB1436395A (en) * | 1973-12-13 | 1976-05-19 | Ici Ltd | Morpholine derivatives |
| DK0429676T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1989-06-16 | 1997-03-10 | Santen Pharmaceutical Co Ltd | |
| US5696117A (en) * | 1995-11-07 | 1997-12-09 | Ortho Pharmaceutical Corporation | Benzoxazine antimicrobial agents |
| US5977130A (en) * | 1996-01-17 | 1999-11-02 | Taiho Pharmeutical Co., Ltd. | Intimal hypertrophy inhibitors |
| US5707990A (en) * | 1996-01-30 | 1998-01-13 | Ortho Pharmaceutical Corporation | 2-substituted amino and thio alkyl benzoxazine antimicrobial agents |
| NZ506985A (en) | 1998-03-31 | 2003-10-31 | Warner Lambert Co | Benzoxazinones/benzothiazinones as serine protease inhibitors |
| DE60216281T2 (de) | 2001-06-29 | 2007-07-05 | Ab Science | Die verwendung von tyrosinkinasehemmer zur behandlung von allergischen erkrankungen |
| CA2452366A1 (en) * | 2001-06-29 | 2003-01-16 | Ab Science | Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis |
| DK1401415T3 (da) * | 2001-06-29 | 2006-10-16 | Ab Science | Anvendelse af N-phenyl-2-pyrimidinamin-derivater til behandling af inflammatoriske sygdomme |
| WO2003004007A2 (en) * | 2001-06-29 | 2003-01-16 | Ab Science | Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (ibd) |
| DE60227709D1 (de) * | 2001-06-29 | 2008-08-28 | Ab Science | Die verwendung von c-kithemmern zur behandlung von autoimmunerkrankungen |
| WO2003003006A2 (en) * | 2001-06-29 | 2003-01-09 | Ab Science | New potent, selective and non toxic c-kit inhibitors |
| JP2005511506A (ja) * | 2001-09-20 | 2005-04-28 | アブ サイエンス | 間質性膀胱炎を治療するための強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤の使用方法 |
| EP1461032B1 (en) * | 2001-09-20 | 2008-07-16 | AB Science | Use of c-kit inhibitors for promoting hair growth |
| JP2005507916A (ja) * | 2001-09-20 | 2005-03-24 | アブ サイエンス | 細菌感染症を治療するための、強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤の使用方法 |
| CA2477111A1 (en) * | 2002-02-27 | 2003-09-04 | Ab Science | Use of tyrosine kinase inhibitors for treating cns disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3166554A (en) * | 1965-01-19 | Certificate of correction | ||
| US3341519A (en) * | 1965-04-28 | 1967-09-12 | Squibb & Sons Inc | Novel benzoxazines, benzothiazines, benzoxazepins and benzothiazepins |
-
1970
- 1970-10-20 US US00082509A patent/US3725403A/en not_active Expired - Lifetime
-
1971
- 1971-10-13 CA CA125,021A patent/CA995669A/en not_active Expired
- 1971-10-18 HU HUSU681A patent/HU163947B/hu unknown
- 1971-10-19 CH CH1524071A patent/CH539633A/fr not_active IP Right Cessation
- 1971-10-20 GB GB4882871A patent/GB1374283A/en not_active Expired
- 1971-10-20 FR FR7137709A patent/FR2111728B1/fr not_active Expired
- 1971-10-20 DE DE19712152282 patent/DE2152282A1/de active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0241006A3 (en) * | 1986-04-10 | 1988-08-10 | E.I. Du Pont De Nemours And Company | 3,3-disubstituted indolines |
| EP0303180A1 (de) * | 1987-08-12 | 1989-02-15 | Hoechst Aktiengesellschaft | Benzothiazinon-oxide, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und deren Verwendung sowie Zwischenprodukte zu ihrer Herstellung |
| US5015642A (en) * | 1987-08-12 | 1991-05-14 | Hoechst Aktiengesellschaft | Benzothiazinone oxides, processes for their preparation, medicaments containing them and the use thereof, and intermediates for their preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2111728A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-06-09 |
| CH539633A (fr) | 1973-07-31 |
| CA995669A (en) | 1976-08-24 |
| US3725403A (en) | 1973-04-03 |
| FR2111728B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-08-01 |
| HU163947B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-11-28 |
| DE2152282A1 (de) | 1972-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |