GB1367576A - Diuretics and agents useful in the treatment of hyperaldosteronism - Google Patents

Diuretics and agents useful in the treatment of hyperaldosteronism

Info

Publication number
GB1367576A
GB1367576A GB4673572A GB4673572A GB1367576A GB 1367576 A GB1367576 A GB 1367576A GB 4673572 A GB4673572 A GB 4673572A GB 4673572 A GB4673572 A GB 4673572A GB 1367576 A GB1367576 A GB 1367576A
Authority
GB
United Kingdom
Prior art keywords
formula
hydrogen
nhr
nrcn
imidazolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4673572A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB1367576A publication Critical patent/GB1367576A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/46—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1367576 Tetrasubstituted imidazolidines AMERICAN CYANAMID CO 10 Oct 1972 [21 Oct 1971] 46735/72 Heading C2C [Also in Division A5] The invention comprises compounds having the general formula wherein X is a hydrogen or chlorine atom; and Y and Z are each NH, NCH 3 or O; with the proviso that both Y and Z are not O in the same compound, and pharmaceutically acceptable salts thereof. They may be prepared by the consecutive steps of (a) reacting an aniline of the formula with an acetic acid derivative of the formula to produce an intermediate of the formula (b) cyclizing Formula IV to form an imidazolidine of Formula I wherein B and D are NHR, NRCN or B and D not being the same and when B is D may also be OR, SR or NHR, A is a leaving group; B<SP>1</SP> is cyano, hydrogen or when B<SP>1</SP> is hydrogen, D can also be OCN; provided that when D is NHR, B<SP>1</SP> CN or and when D is NRCN or B<SP>1</SP> is hydrogen; Z<SP>1</SP> is NH 2 , OCH 3 , OH, SCH 3 , or NHCH 3 ; and R is CH 3 or hydrogen in which case the imidazolidine is methylated after step (b). The compounds of the invention may be used to antagonize renal aldosteronic action and induce diuresis alone or in admixture with conventional carriers and/or other diuretic agents. They may be administered parenterally in solution in a polyhydric aliphatic alcohol which may also contain preservatives to prevent bacterial and fungal contamination, and antioxidants; and orally in the form of tablets, troches, capsules, elixirs, suspensions, syrups, wafers and chewing gum.
GB4673572A 1971-10-21 1972-10-10 Diuretics and agents useful in the treatment of hyperaldosteronism Expired GB1367576A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19147071A 1971-10-21 1971-10-21

Publications (1)

Publication Number Publication Date
GB1367576A true GB1367576A (en) 1974-09-18

Family

ID=22705628

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4673572A Expired GB1367576A (en) 1971-10-21 1972-10-10 Diuretics and agents useful in the treatment of hyperaldosteronism

Country Status (15)

Country Link
JP (1) JPS4849909A (en)
AR (1) AR197582A1 (en)
AU (1) AU476564B2 (en)
BE (1) BE790380A (en)
BG (1) BG20185A1 (en)
CA (1) CA1000714A (en)
CH (1) CH577979A5 (en)
DD (1) DD102695A5 (en)
DE (1) DE2251354A1 (en)
ES (1) ES407856A1 (en)
FR (1) FR2161917B1 (en)
GB (1) GB1367576A (en)
NL (1) NL7214244A (en)
SU (1) SU489327A3 (en)
ZA (1) ZA727251B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933917A1 (en) * 1979-08-22 1981-03-26 Basf Ag, 67063 Ludwigshafen 5-IMINO-IMIDAZOLIDIN-2-ONE AND HERBICIDES CONTAINING THEM.
DE3342849A1 (en) * 1983-11-26 1985-06-13 Erwin Mehne GmbH & Co, 7100 Heilbronn Container transport system
DE19532668A1 (en) 1995-09-05 1997-03-06 Dresden Arzneimittel Novel, anticonvulsant 1-ar (alk) yl-imidazolin-2-ones which contain a disubstituted amine radical in the 4-position, and process for their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE281051C (en) *
US2557911A (en) * 1950-04-19 1951-06-19 American Cyanamid Co Method of preparing glycocyamidines

Also Published As

Publication number Publication date
JPS4849909A (en) 1973-07-14
FR2161917B1 (en) 1976-08-20
NL7214244A (en) 1973-04-25
BE790380A (en) 1973-04-20
AU476564B2 (en) 1976-09-30
CA1000714A (en) 1976-11-30
DE2251354A1 (en) 1973-04-26
SU489327A3 (en) 1975-10-25
AU4771272A (en) 1974-04-26
DD102695A5 (en) 1973-12-20
ES407856A1 (en) 1976-01-16
BG20185A1 (en) 1975-11-05
ZA727251B (en) 1973-06-27
AR197582A1 (en) 1974-04-23
FR2161917A1 (en) 1973-07-13
CH577979A5 (en) 1976-07-30

Similar Documents

Publication Publication Date Title
PL246224A1 (en) Process for preparing novel derivatives of 1,2,3,5-tetra-hydroimidazo/2,1-b/quinazoline
ES363147A1 (en) Substituted phenylacetyl derivatives of guanidine o-alkylisoureas s-alkylisothioureas and p-nitrobenzylisothiourea
IE35909L (en) Acetoxylidides
EP0190356A4 (en) Novel amidine compounds.
GB1488692A (en) Pyrazolo(3,4,6)quinolines
GB1367576A (en) Diuretics and agents useful in the treatment of hyperaldosteronism
GB1334967A (en) Trcyclic imines and a process for the manufacture thereof
GB1213172A (en) Dibenzothiazepine derivatives and production of the same
GB1322636A (en) Oligomeric quaternary ammonium antibacterial agents
TW198037B (en)
GB1437896A (en) Substituted thiazole-2-carboxylic amides and process for the preparation thereof
GB1409648A (en) Substituted pyrrolidinemethanol compounds and pharmaceutical compositions thereof
ATE42295T1 (en) PENEM DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, THEIR USE AND PHARMACEUTICAL COMPOSITIONS.
IE40626B1 (en) Benzophenone derivatives and their production
GB1429571A (en) 4-aryl-5-aminoalkyl-4-oxazolin-2ones
GB1416421A (en) 1,4-dihydro-3 2h- isoquinolinone derivatives and preparation thereof
SE7407493L (en)
IE35223L (en) Bis-basic ethers of 2, 6- and 2, 7-dihydroxy-anthraquinones
EP0318795A3 (en) Pharmaceutically active pteridin derivatives
GB1322069A (en) Aminoalkanoylaminocyclohexane derivatives
IE42962L (en) Phthalimidine and benzisothiazoline derivatives.
GB1238693A (en)
GB1265051A (en)
IE33446B1 (en) New isothiocyano-diphenylamines their production and compositions containing same
US3654264A (en) N-cyclohexyl-3-guanidinoazetidine

Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees