GB1356374A - Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol - Google Patents
Mononitrate esters of 1,3 3,6-dianhydro-d-glucitolInfo
- Publication number
- GB1356374A GB1356374A GB1882172A GB1882172A GB1356374A GB 1356374 A GB1356374 A GB 1356374A GB 1882172 A GB1882172 A GB 1882172A GB 1882172 A GB1882172 A GB 1882172A GB 1356374 A GB1356374 A GB 1356374A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nitrate
- dianhydro
- glucitol
- introduce
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002148 esters Chemical class 0.000 title 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 sulphanoyl Chemical group 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- VJMAITQRABEEKP-UHFFFAOYSA-N [6-(phenylmethoxymethyl)-1,4-dioxan-2-yl]methyl acetate Chemical compound O1C(COC(=O)C)COCC1COCC1=CC=CC=C1 VJMAITQRABEEKP-UHFFFAOYSA-N 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 229910001923 silver oxide Inorganic materials 0.000 abstract 1
- 229960002920 sorbitol Drugs 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13880571A | 1971-04-29 | 1971-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1356374A true GB1356374A (en) | 1974-06-12 |
Family
ID=22483733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1882172A Expired GB1356374A (en) | 1971-04-29 | 1972-04-24 | Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol |
Country Status (10)
| Country | Link |
|---|---|
| AU (1) | AU465217B2 (enrdf_load_stackoverflow) |
| CA (1) | CA967164A (enrdf_load_stackoverflow) |
| CH (1) | CH576475A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2221080C2 (enrdf_load_stackoverflow) |
| DK (1) | DK138182B (enrdf_load_stackoverflow) |
| FR (1) | FR2134698B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1356374A (enrdf_load_stackoverflow) |
| NL (1) | NL7205786A (enrdf_load_stackoverflow) |
| SE (1) | SE385895B (enrdf_load_stackoverflow) |
| ZA (1) | ZA722868B (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559351A (en) * | 1982-12-29 | 1985-12-17 | Heinrich Mack Nachf. | Dihydropyridine derivatives of 1,4:3,6-dianhydrohexitols |
| EP0167008A3 (en) * | 1984-06-06 | 1987-04-15 | Heinrich Mack Nachf. | 1,4:3,6-dianhydro-hexite derivatives, process for their preparation and their use as medicaments |
| ES2340353A1 (es) * | 2008-07-22 | 2010-06-01 | Lacer, S.A. | Nuevo metodo estereoespecifico para la preparacion de compuestos de dioxa-biciclooctano. |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065488A (en) * | 1977-02-24 | 1977-12-27 | American Home Products Corporation | Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate |
| DE3028272A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Durch purinbasen substituierte alkylamino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung |
| DE3028289C2 (de) * | 1980-07-25 | 1986-11-27 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| DE3028288A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Gegebenenfalls n-substituierte aminodesoxy-1.4;3.6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und deren verwendung |
| DE3028340C2 (de) * | 1980-07-25 | 1987-02-05 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | Amino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| EP0143507B1 (en) * | 1983-11-25 | 1989-09-20 | TOSHIN CHEMICAL CO., Ltd. | A method for the preparation of isosorbide-5-nitrate and sodium isosorbide-5-nitrate hydrate as a precursor thereof |
| DE4410997A1 (de) * | 1994-03-30 | 1995-10-26 | Isis Pharma Gmbh | Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen |
| ES2142773B1 (es) | 1998-10-07 | 2001-01-01 | Lacer Sa | Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida. |
| ES2258365B1 (es) * | 2003-10-03 | 2007-12-01 | Lacer, S.A. | Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos. |
| DE102008050597A1 (de) | 2008-10-09 | 2010-04-15 | Actavis Deutschland Gmbh & Co. Kg | Pharmazeutische Zubereitungen zur Anwendung in einem Verfahren zur therapeutischen Behandlung von Hörsturz |
| WO2010055138A1 (en) * | 2008-11-14 | 2010-05-20 | Lacer, S.A. | New stereospecific method for the preparation of dioxa-bicyclooctane compounds |
-
1972
- 1972-04-24 GB GB1882172A patent/GB1356374A/en not_active Expired
- 1972-04-24 AU AU41496/72A patent/AU465217B2/en not_active Expired
- 1972-04-27 DK DK213972AA patent/DK138182B/da unknown
- 1972-04-28 NL NL7205786A patent/NL7205786A/xx not_active Application Discontinuation
- 1972-04-28 ZA ZA722868A patent/ZA722868B/xx unknown
- 1972-04-28 CH CH635272A patent/CH576475A5/xx not_active IP Right Cessation
- 1972-04-28 FR FR7215418A patent/FR2134698B1/fr not_active Expired
- 1972-04-28 CA CA140846A patent/CA967164A/en not_active Expired
- 1972-04-28 SE SE7205716A patent/SE385895B/xx unknown
- 1972-04-28 DE DE2221080A patent/DE2221080C2/de not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559351A (en) * | 1982-12-29 | 1985-12-17 | Heinrich Mack Nachf. | Dihydropyridine derivatives of 1,4:3,6-dianhydrohexitols |
| EP0167008A3 (en) * | 1984-06-06 | 1987-04-15 | Heinrich Mack Nachf. | 1,4:3,6-dianhydro-hexite derivatives, process for their preparation and their use as medicaments |
| ES2340353A1 (es) * | 2008-07-22 | 2010-06-01 | Lacer, S.A. | Nuevo metodo estereoespecifico para la preparacion de compuestos de dioxa-biciclooctano. |
| ES2340353B1 (es) * | 2008-07-22 | 2011-05-23 | Lacer, S.A. | Nuevo metodo estereoespecifico para la preparacion de compuestos de dioxa-biciclooctano. |
Also Published As
| Publication number | Publication date |
|---|---|
| AU465217B2 (en) | 1975-09-18 |
| NL7205786A (enrdf_load_stackoverflow) | 1972-10-31 |
| FR2134698B1 (enrdf_load_stackoverflow) | 1975-12-26 |
| CA967164A (en) | 1975-05-06 |
| AU4149672A (en) | 1973-11-01 |
| DE2221080A1 (de) | 1972-11-09 |
| DE2221080C2 (de) | 1984-06-28 |
| ZA722868B (en) | 1973-12-19 |
| CH576475A5 (enrdf_load_stackoverflow) | 1976-06-15 |
| FR2134698A1 (enrdf_load_stackoverflow) | 1972-12-08 |
| DK138182C (enrdf_load_stackoverflow) | 1978-12-27 |
| SE385895B (sv) | 1976-07-26 |
| DK138182B (da) | 1978-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |