GB1356145A - Production of n-substituted 3,3 disubstituted beta lactams - Google Patents
Production of n-substituted 3,3 disubstituted beta lactamsInfo
- Publication number
- GB1356145A GB1356145A GB4528071A GB4528071A GB1356145A GB 1356145 A GB1356145 A GB 1356145A GB 4528071 A GB4528071 A GB 4528071A GB 4528071 A GB4528071 A GB 4528071A GB 1356145 A GB1356145 A GB 1356145A
- Authority
- GB
- United Kingdom
- Prior art keywords
- disubstituted
- substituted
- production
- sept
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003952 β-lactams Chemical class 0.000 title 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 150000007514 bases Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702048080 DE2048080C3 (de) | 1970-09-30 | 1970-09-30 | Verfahren zur Herstellung von N-substituierten 33-disubstituierten ß -Lactamen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1356145A true GB1356145A (en) | 1974-06-12 |
Family
ID=5783810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4528071A Expired GB1356145A (en) | 1970-09-30 | 1971-09-29 | Production of n-substituted 3,3 disubstituted beta lactams |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE773173A (enExample) |
| CH (1) | CH546759A (enExample) |
| DE (1) | DE2048080C3 (enExample) |
| FR (1) | FR2108681A5 (enExample) |
| GB (1) | GB1356145A (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994017038A1 (en) * | 1993-01-21 | 1994-08-04 | Schering Corporation | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
| CN109906218A (zh) * | 2016-08-01 | 2019-06-18 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| US12084444B2 (en) | 2016-08-01 | 2024-09-10 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam NMDA modulators and methods of using same |
-
1970
- 1970-09-30 DE DE19702048080 patent/DE2048080C3/de not_active Expired
-
1971
- 1971-08-17 CH CH1206671A patent/CH546759A/xx not_active IP Right Cessation
- 1971-09-28 BE BE773173A patent/BE773173A/xx unknown
- 1971-09-29 GB GB4528071A patent/GB1356145A/en not_active Expired
- 1971-09-29 FR FR7135008A patent/FR2108681A5/fr not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994017038A1 (en) * | 1993-01-21 | 1994-08-04 | Schering Corporation | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
| US5698548A (en) * | 1993-01-21 | 1997-12-16 | Schering Corporation | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
| CN109906218A (zh) * | 2016-08-01 | 2019-06-18 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| US11512051B2 (en) | 2016-08-01 | 2022-11-29 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| CN109906218B (zh) * | 2016-08-01 | 2023-01-17 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| US12084444B2 (en) | 2016-08-01 | 2024-09-10 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam NMDA modulators and methods of using same |
| US12157736B2 (en) | 2016-08-01 | 2024-12-03 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam NMDA modulators and methods of using same |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2048080C3 (de) | 1979-11-29 |
| DE2048080B2 (de) | 1979-04-05 |
| DE2048080A1 (enExample) | 1972-05-25 |
| CH546759A (de) | 1974-03-15 |
| BE773173A (fr) | 1972-03-28 |
| FR2108681A5 (enExample) | 1972-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |