GB1351549A - 1,3-dhiydro-3-hydroxy-5-phenyl-2h-1,4-benzodiazepin-2-one sub stituted diamino acetate esters and their acid salts - Google Patents
1,3-dhiydro-3-hydroxy-5-phenyl-2h-1,4-benzodiazepin-2-one sub stituted diamino acetate esters and their acid saltsInfo
- Publication number
- GB1351549A GB1351549A GB1331572A GB1331572A GB1351549A GB 1351549 A GB1351549 A GB 1351549A GB 1331572 A GB1331572 A GB 1331572A GB 1331572 A GB1331572 A GB 1331572A GB 1351549 A GB1351549 A GB 1351549A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lower alkyl
- aryl
- alkyl
- amino
- dhiydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 150000001242 acetic acid derivatives Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 16
- 150000001875 compounds Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- -1 amino, piperidino Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12963871A | 1971-03-30 | 1971-03-30 | |
| US05/223,712 US4065451A (en) | 1971-03-30 | 1972-02-04 | 1,3-Dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, substituted diamino acetate esters and their acid salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1351549A true GB1351549A (en) | 1974-05-01 |
Family
ID=26827785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1331572A Expired GB1351549A (en) | 1971-03-30 | 1972-03-22 | 1,3-dhiydro-3-hydroxy-5-phenyl-2h-1,4-benzodiazepin-2-one sub stituted diamino acetate esters and their acid salts |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4065451A (enExample) |
| JP (1) | JPS5724347B1 (enExample) |
| CH (1) | CH583209A5 (enExample) |
| DE (1) | DE2215440A1 (enExample) |
| FR (1) | FR2132195B1 (enExample) |
| GB (1) | GB1351549A (enExample) |
| IE (1) | IE36213B1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT361492B (de) * | 1978-12-18 | 1981-03-10 | Gerot Pharmazeutika | Verfahren zur herstellung von neuen 3-hydroxy- 1,4-benzodiazepin-2-onen |
| IT1165588B (it) * | 1983-03-23 | 1987-04-22 | Medosan Ind Biochimi | 1,4 benzodiazepine terapeuticamente attive |
| CA1332410C (en) * | 1984-06-26 | 1994-10-11 | Roger M. Freidinger | Benzodiazepine analogs |
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| EP3468545A4 (en) | 2016-06-08 | 2020-07-22 | President and Fellows of Harvard College | METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME AND FRAGILE X SYNDROME |
| AU2019272778B2 (en) | 2018-05-22 | 2024-10-03 | President And Fellows Of Harvard College | Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment |
| AU2019279858A1 (en) | 2018-05-29 | 2020-11-26 | President And Fellows Of Harvard College | Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment |
| EP3946390A4 (en) * | 2019-03-25 | 2022-12-21 | President and Fellows of Harvard College | COMPOSITIONS AND METHODS TO REDUCE TACTILE DYSFUNCTION, ANXIETY AND SOCIAL DISABILITIES |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL298071A (enExample) * | 1963-06-04 | |||
| FR135F (enExample) * | 1964-08-13 |
-
1972
- 1972-02-04 US US05/223,712 patent/US4065451A/en not_active Expired - Lifetime
- 1972-03-22 GB GB1331572A patent/GB1351549A/en not_active Expired
- 1972-03-23 IE IE375/72A patent/IE36213B1/xx unknown
- 1972-03-29 FR FR7211084A patent/FR2132195B1/fr not_active Expired
- 1972-03-29 JP JP3152872A patent/JPS5724347B1/ja active Pending
- 1972-03-29 DE DE19722215440 patent/DE2215440A1/de not_active Withdrawn
- 1972-03-30 CH CH482272A patent/CH583209A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE36213B1 (en) | 1976-09-15 |
| IE36213L (en) | 1972-09-30 |
| DE2215440A1 (de) | 1972-10-19 |
| CH583209A5 (enExample) | 1976-12-31 |
| FR2132195A1 (enExample) | 1972-11-17 |
| FR2132195B1 (enExample) | 1976-07-02 |
| JPS5724347B1 (enExample) | 1982-05-24 |
| US4065451A (en) | 1977-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |