GB1350237A - Cyclopentane derivatives and the preparation thereof - Google Patents
Cyclopentane derivatives and the preparation thereofInfo
- Publication number
- GB1350237A GB1350237A GB2202271A GB2202271A GB1350237A GB 1350237 A GB1350237 A GB 1350237A GB 2202271 A GB2202271 A GB 2202271A GB 2202271 A GB2202271 A GB 2202271A GB 1350237 A GB1350237 A GB 1350237A
- Authority
- GB
- United Kingdom
- Prior art keywords
- novel
- carbon atoms
- contain
- pge
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000001511 cyclopentyl group Chemical class [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003180 prostaglandins Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1350237 Prostaglandin derivatives UPJOHN CO 19 April 1971 [9 March 1970] 22022/71 Heading C2C Prostaglandin derivatives of the formula wherein R 1 is H, C 1-8 alkyl, or a pharmacologically acceptable cation, a is 0 or 1, n is 2 to 8, m is 1 to 5 and # indicates attachment of OH to the ring in alpha or beta-configuration with the provisos that the compound contains 18, 19, 20, 21 or 22 carbon atoms exclusive of R 1 , and that the chain does not contain 7 carbon atoms exclusive of and when a is 0 m is not 4, which are novel when the OH group is in the beta configuration, are prepared by carbonyl reduction of the corresponding PGE 1 or PGE 2 acids or esters, followed by, if desired, separation of the α- and #-isomers thus obtained. The novel esters may also be obtained by esterification of the corresponding free acids. Pharmaceutical compositions, suitable for oral parenteral, rectal or topical administration, contain the above novel compounds with pharmaceuticably acceptable carriers. The compounds possess pharmacological activities similar to those of the natural prostaglandins.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1787470A | 1970-03-09 | 1970-03-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1350237A true GB1350237A (en) | 1974-04-18 |
Family
ID=21785018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2202271A Expired GB1350237A (en) | 1970-03-09 | 1971-04-19 | Cyclopentane derivatives and the preparation thereof |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE764000A (en) |
| CA (1) | CA927392A (en) |
| DE (1) | DE2110938A1 (en) |
| FR (1) | FR2085686B1 (en) |
| GB (1) | GB1350237A (en) |
| IL (1) | IL36196A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2258668C3 (en) * | 1971-12-03 | 1981-08-06 | Syntex Corp., Panama-City | New prostaglandins, processes for their production and pharmaceuticals containing them |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6911506A (en) * | 1968-07-29 | 1970-02-02 | Derivatives related prostaglandins |
-
1971
- 1971-02-11 CA CA105135A patent/CA927392A/en not_active Expired
- 1971-02-16 IL IL36196A patent/IL36196A/en unknown
- 1971-03-08 FR FR7107981A patent/FR2085686B1/fr not_active Expired
- 1971-03-08 DE DE19712110938 patent/DE2110938A1/en active Pending
- 1971-03-09 BE BE764000A patent/BE764000A/en not_active IP Right Cessation
- 1971-04-19 GB GB2202271A patent/GB1350237A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL36196A0 (en) | 1971-04-28 |
| IL36196A (en) | 1975-03-13 |
| FR2085686A1 (en) | 1971-12-31 |
| BE764000A (en) | 1971-09-09 |
| CA927392A (en) | 1973-05-29 |
| FR2085686B1 (en) | 1975-01-17 |
| DE2110938A1 (en) | 1971-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |