GB1350135A - Penicillin derivatives - Google Patents

Penicillin derivatives

Info

Publication number
GB1350135A
GB1350135A GB1350135DA GB1350135A GB 1350135 A GB1350135 A GB 1350135A GB 1350135D A GB1350135D A GB 1350135DA GB 1350135 A GB1350135 A GB 1350135A
Authority
GB
United Kingdom
Prior art keywords
group
aminopenicilleric
penicillins
carboxy
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB1350135A publication Critical patent/GB1350135A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1350135 Preparation of α-carboxy-penicillins CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT 16 Aug 1971 [18 Aug 1970] 38384/71 Heading C2A The invention comprises a process for the preparation of 6-aminopenicilleric acid derivatives of the general Formula I and salts thereof which comprises hydrolysing a 6-aminopenicilleric acid derivative of the general Formula II or a salt or an ester thereof, wherein R 1 represents hydrogen or an alkyl, aryl, arathyl, aryloxy or heterocyclic group, R<SP>2</SP> represents hydrogen or an alkyl, aryl, or aralkyl group, X represents a halogen atom, 7 represents a valeny bond or a (-CO-NH-CHR 3 -) n group wherein R<SP>3</SP> represents hydrogen or an alkyl, aryl, aralkyl, aryloxy or heterocyclic group, n represents an integral number and 6APA the 6-aminopenicilleric acid group. The process may be performed under weakly alkaline conditions, e.g. in the presence of an alkali metal hydrogen carbonate, an alkali metal borate or an alkali metal hydroxide. The reaction may be performed at a temperature between +5‹ C. and -10‹ C. The invention also comprises α-carboxyp - chlorobenzyl - penicillin, α - [(α<SP>1</SP> - carboxy)- α<SP>1</SP> - (p - chlorophenyl)] - acetamido - benzylpenicillin, α - [α<SP>1</SP> - carboxy) - α<SP>1</SP> - (o - ehlorophenyl)] - acetamido - benzylpenicillin and salts of these penicillins. The last-mentioned penicillins may be employed as antibiotically active ingredients in pharmaceutical preparations, veterinary products and animal feeds.
GB1350135D 1971-08-16 1971-08-16 Penicillin derivatives Expired GB1350135A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3838471 1971-08-16

Publications (1)

Publication Number Publication Date
GB1350135A true GB1350135A (en) 1974-04-18

Family

ID=10403132

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1350135D Expired GB1350135A (en) 1971-08-16 1971-08-16 Penicillin derivatives

Country Status (1)

Country Link
GB (1) GB1350135A (en)

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Legal Events

Date Code Title Description
PS Patent sealed
435 Patent endorsed 'licences of right' on the date specified (sect. 35/1949)
PCNP Patent ceased through non-payment of renewal fee