GB1343113A - Insulin derivatives - Google Patents

Insulin derivatives

Info

Publication number
GB1343113A
GB1343113A GB1343113DA GB1343113A GB 1343113 A GB1343113 A GB 1343113A GB 1343113D A GB1343113D A GB 1343113DA GB 1343113 A GB1343113 A GB 1343113A
Authority
GB
United Kingdom
Prior art keywords
amino group
acyl
protected
acid
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Publication of GB1343113A publication Critical patent/GB1343113A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1343113 Insulins NATIONAL RESEARCH DEVELOPMENT CORP 11 Nov 1970 [8 May 1970] 22342/70 Heading C2C A physiologically acceptable substantially pure mono-, di- or tri-substituted insulin in which the terminal amino group of the B-chain (B 1 -phenylalanine) is protected by an acyl or other blocking substituent containing up to 7C and the terminal amino group of the A-chain (A 1 -glycine) is either free or protected by an acyl or other blocking substituent containing no more than 4C and no free primary amino group is prepared by reacting an insulin with an acylating agent or other blocking reagent to acylate or otherwise block the amino group of the B 1 - amino acid and optionally block the A 1 and/or B 29 amino acid and separating the mono-, di- or trisubstituted product. The N-hydroxy succinimide esters of acetic acid and 2,2-dimethyl-3-formyl-L-thiazolidine-4-car boxylic acid are prepared. Pharmaceutical compositions contain the compounds of the invention in forms suitable for injection.
GB1343113D 1970-05-08 1970-11-11 Insulin derivatives Expired GB1343113A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2234270 1970-05-08

Publications (1)

Publication Number Publication Date
GB1343113A true GB1343113A (en) 1974-01-10

Family

ID=10177851

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1343113D Expired GB1343113A (en) 1970-05-08 1970-11-11 Insulin derivatives

Country Status (3)

Country Link
JP (1) JPS495356B1 (en)
DE (1) DE2023447A1 (en)
GB (1) GB1343113A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011003820A1 (en) * 2009-07-06 2011-01-13 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
WO2018190125A1 (en) 2017-04-13 2018-10-18 横河電機株式会社 Confocal scanner, microscope system, and confocal microscope

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin

Also Published As

Publication number Publication date
JPS495356B1 (en) 1974-02-06
DE2023447A1 (en) 1971-11-25

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee