GB1336634A - 5,10-methano-dibenzo-a,d-cycloheptene derivatives and a process for their manufacture - Google Patents
5,10-methano-dibenzo-a,d-cycloheptene derivatives and a process for their manufactureInfo
- Publication number
- GB1336634A GB1336634A GB2136871A GB2136871A GB1336634A GB 1336634 A GB1336634 A GB 1336634A GB 2136871 A GB2136871 A GB 2136871A GB 2136871 A GB2136871 A GB 2136871A GB 1336634 A GB1336634 A GB 1336634A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alk
- radical
- dihydro
- formula
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- 125000003277 amino group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 10,11-dihydro-5,10-methano- 5H - dibenzo - [a,d] - cycloheptenyl Chemical group 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000004089 psychotropic agent Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- NXZDFCLTUMPFCZ-UHFFFAOYSA-N 15-[3-(dimethylamino)propyl]tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaen-15-ol Chemical compound CN(CCCC1(CC2C3=CC=CC=C3C1C=1C=CC=CC2=1)O)C NXZDFCLTUMPFCZ-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- GCBBMVDZNMWXCD-UHFFFAOYSA-N 8-hydroxytetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10,12,14-hexaene-9-carboxylic acid Chemical compound C(=O)(O)C12C(C3=C(C(C4=C1C=CC=C4)C2)C=CC=C3)O GCBBMVDZNMWXCD-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
- NDYLAABPGFMVIY-UHFFFAOYSA-M [Cl-].CN(C)CCC[Mg+] Chemical compound [Cl-].CN(C)CCC[Mg+] NDYLAABPGFMVIY-UHFFFAOYSA-M 0.000 abstract 1
- FGNVGVBNBOAUFU-UHFFFAOYSA-N ac1l7jmm Chemical compound C12=CC=CC=C2C2CC(=O)C1C1=CC=CC=C12 FGNVGVBNBOAUFU-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000000506 psychotropic effect Effects 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 238000003797 solvolysis reaction Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- KBEMFRAPKQGOEG-UHFFFAOYSA-N tetracyclo[8.5.1.02,7.08,13]hexadeca-2,4,6,8(13),9,11-hexaene Chemical class C1=CC=CC=2C3CCC4=C(C=21)C=C(C=C4)C3 KBEMFRAPKQGOEG-UHFFFAOYSA-N 0.000 abstract 1
- 238000010792 warming Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/39—Unsaturated compounds containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH213770A CH536272A (de) | 1970-02-13 | 1970-02-13 | Verfahren zur Herstellung neuer Amine |
| CH39871 | 1971-01-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1336634A true GB1336634A (en) | 1973-11-07 |
Family
ID=25684450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2136871A Expired GB1336634A (en) | 1970-02-13 | 1971-04-19 | 5,10-methano-dibenzo-a,d-cycloheptene derivatives and a process for their manufacture |
Country Status (9)
| Country | Link |
|---|---|
| AR (1) | AR192567A1 (enrdf_load_stackoverflow) |
| AT (5) | AT314498B (enrdf_load_stackoverflow) |
| AU (1) | AU2537371A (enrdf_load_stackoverflow) |
| BE (1) | BE762886A (enrdf_load_stackoverflow) |
| DE (1) | DE2105158A1 (enrdf_load_stackoverflow) |
| ES (1) | ES388181A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2081507B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1336634A (enrdf_load_stackoverflow) |
| NL (1) | NL7101926A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4076830A (en) * | 1976-04-07 | 1978-02-28 | E. I. Du Pont De Nemours And Company | Alkylmethanodibenzocycloheptapyrroles |
| US4088772A (en) * | 1975-01-30 | 1978-05-09 | E. I. Du Pont De Nemours And Company | Methanodibenzocycloheptapyrroles |
| US5688789A (en) * | 1989-04-14 | 1997-11-18 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3904630A (en) * | 1973-03-08 | 1975-09-09 | Riker Laboratories Inc | 8-n-methylpiperazinyl-n'-carbonyldibenzo-bicyclooctadiene and salts thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1461406A (fr) * | 1964-06-19 | 1966-02-25 | Ciba Geigy | 5, 10-méthanodibenzo [a, d] [1, 4] cycloheptadiènes et procédé pour leur préparation |
| US3505388A (en) * | 1967-03-21 | 1970-04-07 | Merck & Co Inc | 10,11-dihydro-5,10-methanodibenzo-cycloheptenes |
-
1971
- 1971-02-02 FR FR7103359A patent/FR2081507B1/fr not_active Expired
- 1971-02-04 DE DE19712105158 patent/DE2105158A1/de active Pending
- 1971-02-09 AR AR23391771A patent/AR192567A1/es active
- 1971-02-11 ES ES388181A patent/ES388181A1/es not_active Expired
- 1971-02-12 AT AT711972A patent/AT314498B/de not_active IP Right Cessation
- 1971-02-12 AT AT711572A patent/AT313871B/de not_active IP Right Cessation
- 1971-02-12 AT AT711472A patent/AT313870B/de not_active IP Right Cessation
- 1971-02-12 AT AT711672A patent/AT313872B/de not_active IP Right Cessation
- 1971-02-12 AT AT711372A patent/AT312578B/de active
- 1971-02-12 BE BE762886A patent/BE762886A/xx unknown
- 1971-02-12 AU AU25373/71A patent/AU2537371A/en not_active Expired
- 1971-02-12 NL NL7101926A patent/NL7101926A/xx unknown
- 1971-04-19 GB GB2136871A patent/GB1336634A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4088772A (en) * | 1975-01-30 | 1978-05-09 | E. I. Du Pont De Nemours And Company | Methanodibenzocycloheptapyrroles |
| US4076830A (en) * | 1976-04-07 | 1978-02-28 | E. I. Du Pont De Nemours And Company | Alkylmethanodibenzocycloheptapyrroles |
| US5688789A (en) * | 1989-04-14 | 1997-11-18 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
| US6017910A (en) * | 1989-04-14 | 2000-01-25 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2105158A1 (enrdf_load_stackoverflow) | 1971-08-19 |
| ES388181A1 (es) | 1974-02-16 |
| AU2537371A (en) | 1972-08-17 |
| NL7101926A (enrdf_load_stackoverflow) | 1971-08-17 |
| AT312578B (de) | 1974-01-10 |
| AT314498B (de) | 1974-04-10 |
| AT313872B (de) | 1974-03-11 |
| FR2081507B1 (enrdf_load_stackoverflow) | 1974-10-18 |
| BE762886A (fr) | 1971-08-12 |
| FR2081507A1 (enrdf_load_stackoverflow) | 1971-12-03 |
| AR192567A1 (es) | 1973-02-28 |
| AT313870B (de) | 1974-03-11 |
| AT313871B (de) | 1974-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |