GB1323721A - Substituted isoquinolines - Google Patents

Substituted isoquinolines

Info

Publication number
GB1323721A
GB1323721A GB3358870A GB3358870A GB1323721A GB 1323721 A GB1323721 A GB 1323721A GB 3358870 A GB3358870 A GB 3358870A GB 3358870 A GB3358870 A GB 3358870A GB 1323721 A GB1323721 A GB 1323721A
Authority
GB
United Kingdom
Prior art keywords
methoxy
condensing
july
substituted isoquinolines
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3358870A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Publication of GB1323721A publication Critical patent/GB1323721A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

1323721 Substituted isoquinolines AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE 10 July 1970 [11 July 1969] 33588/70 Heading C2C Novel substituted isoquinolines of the Formula I wherein both R 1 are methoxy groups or together form a dioxymethylene group; R 2 is hydrogen, or (except when R 3 represents two methoxy radicals in the 3, 4 positions of the benzyl nucleus) a methyl radical and R 3 is one or more same or different radicals selected from halogen, N-diethyl amino or methoxy attached to any available position(s) on the benzyl nucleus or is a dioxymethylene group attached to adjacent positions on the benzylnuclous, and pharmaceutically acceptable salts and quaternary N- compounds thereof may be prepared by condensing an amino acetal H 2 NCH 2 CH(OR) 2 where R is an alkyl group with a carbonyl II hydrogenating the Schiff base so formed, cyclizing the reduction product and without isolation of the 1,2-dihydroisoquinoline condensing it with a carbonyl derivative of the Formula III Pharmaceutical compositions of the compound I with the usual excipients show spasmolytic activity when administered orally, parenterally or rectally.
GB3358870A 1969-07-11 1970-07-10 Substituted isoquinolines Expired GB1323721A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6923764A FR2054482B1 (en) 1969-07-11 1969-07-11

Publications (1)

Publication Number Publication Date
GB1323721A true GB1323721A (en) 1973-07-18

Family

ID=9037353

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3358870A Expired GB1323721A (en) 1969-07-11 1970-07-10 Substituted isoquinolines

Country Status (12)

Country Link
BE (1) BE753289A (en)
CA (1) CA940132A (en)
CH (1) CH555829A (en)
DE (1) DE2034588C3 (en)
DK (1) DK133778B (en)
ES (1) ES382229A1 (en)
FR (1) FR2054482B1 (en)
GB (1) GB1323721A (en)
LU (1) LU61297A1 (en)
NL (1) NL171268C (en)
NO (1) NO135065C (en)
SE (1) SE368573B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0048539B1 (en) * 1980-07-01 1985-08-28 Ici Australia Limited Isoquinolyloxy(amino)phenoxyalkane carboxylic acid derivatives, process for their synthesis, herbicidal compositions containing them and their use as herbicides
WO2014071044A1 (en) * 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2538231A1 (en) * 1975-08-28 1977-03-10 Dynamit Nobel Ag PROCESS FOR THE PRODUCTION OF AMINOACETALDEHYDACETALS
DE3233424A1 (en) * 1982-09-09 1984-03-15 Hoechst Ag, 6230 Frankfurt ISOCHINOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0048539B1 (en) * 1980-07-01 1985-08-28 Ici Australia Limited Isoquinolyloxy(amino)phenoxyalkane carboxylic acid derivatives, process for their synthesis, herbicidal compositions containing them and their use as herbicides
WO2014071044A1 (en) * 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)

Also Published As

Publication number Publication date
NL171268B (en) 1982-10-01
CH555829A (en) 1974-11-15
FR2054482B1 (en) 1973-06-08
LU61297A1 (en) 1970-09-10
SE368573B (en) 1974-07-08
CA940132A (en) 1974-01-15
DK133778C (en) 1976-12-06
NL171268C (en) 1983-03-01
NO135065B (en) 1976-10-25
DK133778B (en) 1976-07-19
FR2054482A1 (en) 1971-04-23
DE2034588C3 (en) 1979-11-22
DE2034588B2 (en) 1979-03-29
NO135065C (en) 1977-02-02
DE2034588A1 (en) 1971-04-15
BE753289A (en) 1971-01-11
ES382229A1 (en) 1972-12-01
NL7010358A (en) 1971-01-13

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee