GB1319026A - Imidazole derivatives - Google Patents
Imidazole derivativesInfo
- Publication number
- GB1319026A GB1319026A GB2340471*A GB2340471A GB1319026A GB 1319026 A GB1319026 A GB 1319026A GB 2340471 A GB2340471 A GB 2340471A GB 1319026 A GB1319026 A GB 1319026A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- alkoxy
- prepared
- trifluoromethylimidazole
- cooh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 3
- -1 sulphamoyl Chemical group 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- HEPPAPZASXFWTB-UHFFFAOYSA-N 3,3-dibromo-1,1,1-trifluoropropan-2-one Chemical compound FC(F)(F)C(=O)C(Br)Br HEPPAPZASXFWTB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 241000790917 Dioxys <bee> Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000002255 antigout agent Substances 0.000 abstract 1
- 229960002708 antigout preparations Drugs 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005390 cinnolyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000001035 methylating effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- BGUWFUQJCDRPTL-UHFFFAOYSA-N pyridine-4-carbaldehyde Chemical compound O=CC1=CC=NC=C1 BGUWFUQJCDRPTL-UHFFFAOYSA-N 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2012670A | 1970-03-16 | 1970-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1319026A true GB1319026A (en) | 1973-05-31 |
Family
ID=21796910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2340471*A Expired GB1319026A (en) | 1970-03-16 | 1971-04-19 | Imidazole derivatives |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3691178A (enrdf_load_html_response) |
| JP (1) | JPS5425028B1 (enrdf_load_html_response) |
| CA (1) | CA958709A (enrdf_load_html_response) |
| CH (1) | CH565157A5 (enrdf_load_html_response) |
| DE (1) | DE2112349A1 (enrdf_load_html_response) |
| FR (1) | FR2085714B1 (enrdf_load_html_response) |
| GB (1) | GB1319026A (enrdf_load_html_response) |
| NL (1) | NL7102531A (enrdf_load_html_response) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7017486A (enrdf_load_html_response) * | 1969-12-15 | 1971-06-17 | ||
| US3666767A (en) * | 1970-01-28 | 1972-05-30 | Warner Lambert Co | 2-amino-1-(2-imidazolin-2-yl)-2-imidazolines |
| US4035390A (en) * | 1971-06-19 | 1977-07-12 | Lilly Industries, Ltd. | Thiazole derivatives |
| US3812136A (en) * | 1972-05-05 | 1974-05-21 | Merck & Co Inc | Tri-substituted imidazoles |
| US3914246A (en) * | 1972-05-05 | 1975-10-21 | Merck & Co Inc | Tri-substituted imidazoles |
| US4058614A (en) * | 1973-12-04 | 1977-11-15 | Merck & Co., Inc. | Substituted imidazole compounds and therapeutic compositions therewith |
| US4179512A (en) * | 1977-03-01 | 1979-12-18 | Merck & Co., Inc. | 4-Substituted-2-arylimidazoles |
| US4139708A (en) * | 1977-05-24 | 1979-02-13 | Sk&F Lab Co. | Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts |
| US4314844A (en) * | 1979-01-11 | 1982-02-09 | Rohm And Haas Company | Herbicidal substituted imidazoles |
| US4281005A (en) * | 1979-03-05 | 1981-07-28 | Merck & Co., Inc. | Novel 2-pyridylimidazole compounds |
| US4851424A (en) * | 1986-06-06 | 1989-07-25 | Ciba-Geigy Corporation | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy |
| US5872136A (en) * | 1996-04-03 | 1999-02-16 | Merck & Co., Inc. | Arylheteroaryl inhibitors of farnesyl-protein transferase |
| WO2009137742A1 (en) * | 2008-05-08 | 2009-11-12 | Ampac Fine Chemicals Llc | Process for the preparation of cyano-substituted-nitrogen-containing heteroaryl compounds |
| CN101921234B (zh) * | 2009-06-12 | 2012-05-30 | 中国中化股份有限公司 | 一种制备美托咪啶的方法 |
| CN101805294B (zh) * | 2010-01-12 | 2015-06-10 | 北京华禧联合科技发展有限公司 | 盐酸右美托咪定关键中间体的制备 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3147270A (en) * | 1961-11-03 | 1964-09-01 | Warner Lambert Pharmaceutical | Substituted 2-imidazolines |
| FR1487345A (fr) * | 1965-04-16 | 1967-07-07 | Merck & Co Inc | Nouveau procédé de préparation d'alkyl-imidazoles hydroxylés ou hydroxyalkylés en position 1 |
-
1970
- 1970-03-16 US US20126A patent/US3691178A/en not_active Expired - Lifetime
-
1971
- 1971-02-25 NL NL7102531A patent/NL7102531A/xx not_active Application Discontinuation
- 1971-03-01 CA CA106,578A patent/CA958709A/en not_active Expired
- 1971-03-10 JP JP1254771A patent/JPS5425028B1/ja active Pending
- 1971-03-15 DE DE19712112349 patent/DE2112349A1/de active Pending
- 1971-03-15 FR FR7108947A patent/FR2085714B1/fr not_active Expired
- 1971-03-15 CH CH371871A patent/CH565157A5/xx not_active IP Right Cessation
- 1971-04-19 GB GB2340471*A patent/GB1319026A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2085714B1 (enrdf_load_html_response) | 1974-08-02 |
| CH565157A5 (enrdf_load_html_response) | 1975-08-15 |
| CA958709A (en) | 1974-12-03 |
| JPS5425028B1 (enrdf_load_html_response) | 1979-08-24 |
| US3691178A (en) | 1972-09-12 |
| NL7102531A (enrdf_load_html_response) | 1971-09-20 |
| DE2112349A1 (de) | 1971-10-14 |
| FR2085714A1 (enrdf_load_html_response) | 1971-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |