GB1317257A - 4-thiazole carboxyldehyde derivatives - Google Patents
4-thiazole carboxyldehyde derivativesInfo
- Publication number
- GB1317257A GB1317257A GB1317257DA GB1317257A GB 1317257 A GB1317257 A GB 1317257A GB 1317257D A GB1317257D A GB 1317257DA GB 1317257 A GB1317257 A GB 1317257A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- prepared
- nitro
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1317257 Thiazole derivatives LILLY INDUSTRIES Ltd 6 July 1970 [15 July 1969] 54456/72 Divided out of 1317256 Heading C2C Novel compounds of Formula I (in which Y is O or S, n is 0 or 1 and R is H or C 1-6 alkyl) are prepared (a) by condensing a compound of Formula II with a 1-halomethylglyoxal or with an acetal thereof, or with a compound of the formula Hal.CH 2 .CO.CO.R (where Hal is halogen and R is C 1-6 alkyl), or (b) by reacting a compound of Formula III with an alkali metal salt of an acid of formula R<SP>111</SP>COOH (where R<SP>111</SP> is an optionally substituted hydrocarbon radical) to replace the halogen atom by the radical O.CO.R<SP>111</SP>, hydrolysing the resulting ester in the presence of a mineral acid and oxidizing the resulting alcohol to the aldehyde or ketone. The compounds I in which R is H may also be prepared by (i) treating a compound of the Formula IV with p-nitroso dimethyl aniline in the presence of a catalyst and subjecting the resulting N-(pdimethylaminophenyl) - 2 - substituted - 4 - thiazolyl nitrone to acid hydrolysis, or (ii) treating a compound of Formula V with dilute acetic acid. Compounds of Formulae IV and V are prepared by reacting a compound of Formula III (in which R is H) with hexamine or pyridine. 2 - (5 - Nitro - 2 - furyl) - 4 - chloromethylthiazole is prepared by reacting 5-nitro-2-thiocarbamyl-furan with 1,3-dichloro-acetone. The semicarbazone of 2-(5-nitro-2-thienyl)-4- formyl-thiazole and the 2,4-dinitrophenyl hydrazone of 2 - (5 - nitro - 2 - furyl) - 4 - formylthiazole are prepared.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5445672 | 1969-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1317257A true GB1317257A (en) | 1973-05-16 |
Family
ID=10471052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1317257D Expired GB1317257A (en) | 1969-07-15 | 1969-07-15 | 4-thiazole carboxyldehyde derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1317257A (en) |
-
1969
- 1969-07-15 GB GB1317257D patent/GB1317257A/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |