GB1309948A - Benzodiazepine derivatives processes for producing them and compo sitions containing them - Google Patents

Benzodiazepine derivatives processes for producing them and compo sitions containing them

Info

Publication number
GB1309948A
GB1309948A GB2082771A GB2082771A GB1309948A GB 1309948 A GB1309948 A GB 1309948A GB 2082771 A GB2082771 A GB 2082771A GB 2082771 A GB2082771 A GB 2082771A GB 1309948 A GB1309948 A GB 1309948A
Authority
GB
United Kingdom
Prior art keywords
compound
formula
alkyl
producing
feb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2082771A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP969170A external-priority patent/JPS4910954B1/ja
Priority claimed from JP1053370A external-priority patent/JPS4834600B1/ja
Priority claimed from JP5553070A external-priority patent/JPS4831119B1/ja
Priority claimed from JP5552970A external-priority patent/JPS4831118B1/ja
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of GB1309948A publication Critical patent/GB1309948A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • C07D243/36—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings containing an indole or hydrogenated indole ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1309948 Benzodiazepines SUMITOMO CHEMICAL CO Ltd 19 April 1971 [3 Feb 1970 5 Feb 1970 24 June 1970 (2)] 20827/71 Heading C2C Compounds of the general formula (R 1 =H, halogen, NO 2 , CN, CF 3 , C 1-4 alkoxy; R 2 =Py, R 5 R 6 Ph; R 5,6 =H, halogen, CF 3 , Me, Et; R 3 =H, C 1-4 alkyl; R 4 =C 1-4 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-4 alkyl, aryl, aralkyl; m=1, 2; n=1-4) and their salts are preparedby (a) introduction of the 1-substituent, (b) oxidizing the corresponding compound in which m=0 or 1, n=2 or 3 and R 2 is not Py, (c) indole ring-expansion, (d) reacting a compound of the formula with a compound of the formula or (e) removing Z from a compound of the formula (n<SP>1</SP> = 2, 3; Z = nitrogen protecting system), optionally followed in each case by salt formation. The above compounds are tranquillizers, sedatives, muscle relaxants, spasmolytics and hypnotics, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier. Reference has been directed by the Comptroller to Specification 972,968.
GB2082771A 1970-02-03 1971-04-19 Benzodiazepine derivatives processes for producing them and compo sitions containing them Expired GB1309948A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP969170A JPS4910954B1 (en) 1970-02-03 1970-02-03
JP1053370A JPS4834600B1 (en) 1970-02-05 1970-02-05
JP5553070A JPS4831119B1 (en) 1970-06-24 1970-06-24
JP5552970A JPS4831118B1 (en) 1970-06-24 1970-06-24

Publications (1)

Publication Number Publication Date
GB1309948A true GB1309948A (en) 1973-03-14

Family

ID=27455232

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2082771A Expired GB1309948A (en) 1970-02-03 1971-04-19 Benzodiazepine derivatives processes for producing them and compo sitions containing them

Country Status (13)

Country Link
BE (1) BE762404A (en)
CA (1) CA970368A (en)
CH (3) CH549033A (en)
DE (1) DE2166473A1 (en)
DK (1) DK134018B (en)
FI (1) FI52081C (en)
FR (1) FR2081482B1 (en)
GB (1) GB1309948A (en)
IL (1) IL36121A (en)
NL (1) NL169072C (en)
NO (1) NO131031C (en)
PL (1) PL70900B1 (en)
SE (1) SE364714B (en)

Also Published As

Publication number Publication date
CA970368A (en) 1975-07-01
NO131031B (en) 1974-12-16
NL7101382A (en) 1971-08-05
DE2104571B2 (en) 1976-03-04
IL36121A0 (en) 1971-04-28
CH549033A (en) 1974-05-15
FI52081B (en) 1977-02-28
SE364714B (en) 1974-03-04
CH581632A5 (en) 1976-11-15
FR2081482B1 (en) 1975-10-10
DE2104571A1 (en) 1971-08-05
FI52081C (en) 1977-06-10
CH578543A5 (en) 1976-08-13
PL70900B1 (en) 1974-04-30
DK134018B (en) 1976-08-30
NL169072C (en) 1982-06-01
BE762404A (en) 1971-07-16
FR2081482A1 (en) 1971-12-03
DK134018C (en) 1977-01-31
IL36121A (en) 1975-08-31
DE2166473A1 (en) 1974-02-21
NL169072B (en) 1982-01-04
NO131031C (en) 1975-03-25

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee