GB1309727A - Nitrofuryl- and nitrothienyl amidine derivatives - Google Patents
Nitrofuryl- and nitrothienyl amidine derivativesInfo
- Publication number
- GB1309727A GB1309727A GB2821771A GB2821771A GB1309727A GB 1309727 A GB1309727 A GB 1309727A GB 2821771 A GB2821771 A GB 2821771A GB 2821771 A GB2821771 A GB 2821771A GB 1309727 A GB1309727 A GB 1309727A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- alkyl
- triazolo
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 nitrothienyl amidine Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 8
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- BWKAYBPLDRWMCJ-UHFFFAOYSA-N 1,1-diethoxy-n,n-dimethylmethanamine Chemical compound CCOC(N(C)C)OCC BWKAYBPLDRWMCJ-UHFFFAOYSA-N 0.000 abstract 1
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical group N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 abstract 1
- JIZRGGUCOQKGQD-UHFFFAOYSA-N 2-nitrothiophene Chemical class [O-][N+](=O)C1=CC=CS1 JIZRGGUCOQKGQD-UHFFFAOYSA-N 0.000 abstract 1
- FYEHMNBJPAUSAP-UHFFFAOYSA-N 3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine Chemical compound C1=CC(N)=NN2C(C)=NN=C21 FYEHMNBJPAUSAP-UHFFFAOYSA-N 0.000 abstract 1
- SXINBFXPADXIEY-UHFFFAOYSA-N 5-Nitrofurfural Chemical compound [O-][N+](=O)C1=CC=C(C=O)O1 SXINBFXPADXIEY-UHFFFAOYSA-N 0.000 abstract 1
- CHTSWZNXEKOLPM-UHFFFAOYSA-N 5-nitrothiophene-2-carbaldehyde Chemical compound [O-][N+](=O)C1=CC=C(C=O)S1 CHTSWZNXEKOLPM-UHFFFAOYSA-N 0.000 abstract 1
- SAEMZERYKVYXMM-UHFFFAOYSA-N N,N-dimethyl-N'-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)methanimidamide Chemical compound CC1=NN=C2N1N=C(C=C2)N=CN(C)C SAEMZERYKVYXMM-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- YRACHDVMKITFAZ-UHFFFAOYSA-N [1,2,4]triazolo[4,3-b]pyridazine Chemical group C1=CC=NN2C=NN=C21 YRACHDVMKITFAZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000000802 nitrating effect Effects 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 abstract 1
- 229960001907 nitrofurazone Drugs 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702030581 DE2030581A1 (de) | 1970-06-20 | 1970-06-20 | Nitrofuryl-amidin-Derivate und Verfahren zur Herstellung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1309727A true GB1309727A (en) | 1973-03-14 |
Family
ID=5774553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2821771A Expired GB1309727A (en) | 1970-06-20 | 1971-06-16 | Nitrofuryl- and nitrothienyl amidine derivatives |
Country Status (11)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2222834A1 (de) * | 1972-05-10 | 1973-11-29 | Boehringer Mannheim Gmbh | Nitrofuryl-amidin-derivate und verfahren zur herstellung derselben |
| CN101374843B (zh) | 2005-12-21 | 2012-09-05 | 詹森药业有限公司 | 作为酪氨酸激酶调节剂的三唑并哒嗪 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1485277A (fr) * | 1965-07-02 | 1967-06-16 | Boehringer & Soehne Gmbh | Procédé pour la préparation de nouveaux composés 5-nitrofuryle et 5-nitrothiényle |
| US3658796A (en) * | 1968-04-10 | 1972-04-25 | Boehringer Mannheim Gmbh | 5-nitrofuran derivatives |
-
1970
- 1970-06-20 DE DE19702030581 patent/DE2030581A1/de active Pending
-
1971
- 1971-06-15 ZA ZA713906A patent/ZA713906B/xx unknown
- 1971-06-16 NL NL7108264A patent/NL7108264A/xx unknown
- 1971-06-16 GB GB2821771A patent/GB1309727A/en not_active Expired
- 1971-06-16 ES ES392288A patent/ES392288A1/es not_active Expired
- 1971-06-18 AT AT530171A patent/AT304520B/de not_active IP Right Cessation
- 1971-06-18 CA CA116,103A patent/CA942304A/en not_active Expired
- 1971-06-18 SU SU1842826A patent/SU455534A3/ru active
- 1971-06-18 AT AT127272A patent/AT309407B/de not_active IP Right Cessation
- 1971-06-18 FR FR7122199A patent/FR2100800B1/fr not_active Expired
- 1971-06-18 SE SE7107953A patent/SE372769B/xx unknown
- 1971-06-18 IE IE789/71A patent/IE35388B1/xx unknown
- 1971-06-18 SU SU1842000A patent/SU468410A3/ru active
- 1971-06-18 AT AT127172A patent/AT309406B/de not_active IP Right Cessation
- 1971-06-18 SU SU1677748A patent/SU421188A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| AT309406B (de) | 1973-08-27 |
| CA942304A (en) | 1974-02-19 |
| FR2100800B1 (enrdf_load_stackoverflow) | 1975-10-10 |
| SU455534A3 (ru) | 1974-12-30 |
| DE2030581A1 (de) | 1971-12-30 |
| AT304520B (de) | 1973-01-10 |
| ZA713906B (en) | 1972-02-23 |
| NL7108264A (enrdf_load_stackoverflow) | 1971-12-22 |
| IE35388B1 (en) | 1976-02-04 |
| FR2100800A1 (enrdf_load_stackoverflow) | 1972-03-24 |
| IE35388L (en) | 1971-12-20 |
| SU421188A3 (ru) | 1974-03-25 |
| SU468410A3 (ru) | 1975-04-25 |
| SE372769B (enrdf_load_stackoverflow) | 1975-01-13 |
| AT309407B (de) | 1973-08-27 |
| ES392288A1 (es) | 1973-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |