GB1307202A - Quinazoline derivative a process for producing them and compositions containing them - Google Patents
Quinazoline derivative a process for producing them and compositions containing themInfo
- Publication number
- GB1307202A GB1307202A GB1307202DA GB1307202A GB 1307202 A GB1307202 A GB 1307202A GB 1307202D A GB1307202D A GB 1307202DA GB 1307202 A GB1307202 A GB 1307202A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- haloalkyl
- phenyl
- quinazolinones
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1307202 1 - Haloalkyl - 4 - phenyl - 2(1 H)- quinazolinones SUMITOMO CHEMICAL CO Ltd 15 June 1971 28026/71 Heading C2C Novel 1 - haloalkyl - 4 - phenyl - 2(1H)- quinazolinones of the general formula wherein R is an alkyl group substituted by at least two halogen atoms and R 1 , R 2 and R 3 are each a hydrogen or halogen atom or a C 1-4 alkyl, C 1-4 alkoxy, nitro, trifluoromethyl, C 1-4 alkylthio or C 1-4 alkylsulphonyl group, and acid addition salts thereof are prepared by treating a trihaloacetamidobenzophenone of the general formula wherein X is a halogen atom, with ammonia, followed optionally by salification of the product. Trihaloacetamidobenzophenones of the second general formula above are prepared by reacting an o-aminobenzophenone of the general formula with a trihaloacetic acid or a reactive derivative thereof. Pharmaceutical compositions having analgesic and anti-inflammatory activity comprise, as active ingredient, at least one 1-haloalkyl-4- phenyl-2(1H)-quinazolinone of the first general formula above or acid addition salt thereof, together with a pharmaceutically acceptable diluent or carrier, and may be administered orally or parenterally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2802671 | 1971-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1307202A true GB1307202A (en) | 1973-02-14 |
Family
ID=10269070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1307202D Expired GB1307202A (en) | 1971-06-15 | 1971-06-15 | Quinazoline derivative a process for producing them and compositions containing them |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1307202A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2627914A1 (en) | 1975-06-23 | 1977-01-13 | Sumitomo Chemical Co | MEDICINAL PRODUCTS WITH ANTIPHLOGISTICAL EFFECT |
-
1971
- 1971-06-15 GB GB1307202D patent/GB1307202A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2627914A1 (en) | 1975-06-23 | 1977-01-13 | Sumitomo Chemical Co | MEDICINAL PRODUCTS WITH ANTIPHLOGISTICAL EFFECT |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |